Norfloxacin-MK-0366-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemENorfloxacinCat. No.: HY-B0132CAS No.: 70458-96-7Synonyms: MK-0366分式: CHFNO分量: 319.33作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 6.6 mg/mL (20.67 mM; Nee

2、d ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.1316 mL 15.6578 mL 31.3156 mL5 mM 0.6263 mL 3.1316 mL 6.2631 mL10 mM 0.3132 mL 1.5658 mL 3.1316 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Norfloxacin (MK-0366)譜抗素，能通過結(jié)合DNA旋轉(zhuǎn)酶抑制蘭陽性和陰性菌。IC50 & Targ

3、et DNA gyrase; Antibacterial 1 2.體外研究Norfloxacin (MK-0366) is a synthetic chemotherapeutic antibacterial agent occasionally used to treatcommon as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEthat i

4、s active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, atype II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, therebyinhibiting cell division.There are currently three approved uses in the adult population (one of wh

5、ich isrestricted) and the other ineffective due to bacterial resistance.REFERENCES1. Nelson JM, et al. Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a publichealth success story. Clin Infect Dis. 2007 Apr 1;44(7):977-80. Epub 2007 Feb 14.

6、2. Pade?skaia EN. Norfloxacin: more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapyfor infections. Antibiot Khimioter. 2003;48(9):28-36.3. Rafalsky V, et al. Quinolones for uncomplicated acute cystitis in women. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD003597.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 4