Oroxylin-A-Baicalein-6-methyl-ether-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOroxylin ACat. No.: HY-N0560CAS No.: 480-11-5Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein分式: CHO分量: 284.26作靶點(diǎn): HIF/HIF Prolyl-Hydroxylase; Autophagy作通路: Metabolic Enzyme/Protease; Autophagy儲(chǔ)存式: Powder -20C 3 years4C 2

2、yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 32 mg/mL (112.57 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.5179 mL 17.5895 mL 35.1791 mL5 mM 0.7036 mL 3.5179 mL 7.0358 mL10 mM 0.3518 mL 1.7590 mL 3.5179 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)

3、注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (7.32 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL AC

4、TIVITY物活性 千層紙素 (Oroxylin A)種有活性的 酮類化合物，具有較強(qiáng)的抗癌作。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Cancers (Basel). 2019 Mar 12;11(3). pii: E353.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation

5、tostabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41./pubmed/259029142. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 inhuman hepatoma HepG2 cells. Mol Carcinog. 2015

6、Aug 10.3. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2transcription and HIF1 destabilization. Cell Death Dis. 2015 Apr 9McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820