VD-VDR-Activators-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/VD_VDR.html VD/VDRVitamin D; Vitamin D receptorVitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV Bradiation from sunlight. Vitamin D modulates its biological effects by directly regula

2、ting target gene expression through theVitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whethersynthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone,1,25-dyhydroxyvi

3、tamin D 1,25(OH) D , a form that signals through the VDR. The hormone-bound VDR modulates target gene3 2 3transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR byvitamin D induces autophagy and an autophagic transcriptional signatu

4、re in breast cancer (BC) cells.There are 2 forms of vitamin D. Vitamin D (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and2vitamin D (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D and3 2vitamin D .

5、3Topical agents containing active vitamin D (calcitriol, 1, 25- dihydroxyvitaminD , VD ) analogues such as Tacalcitol, Calcipotriol3 3 3and Maxacalcitol are widely used for psoriasis therapy.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html VD/VDR HYPERLINK https:/www.MedChemE/Targets

6、/VD/VDR.html HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html Inhibitors, HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html Agonists, HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html Antagonists, HY

7、PERLINK https:/www.MedChemE/Targets/VD/VDR.html HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html Activators, HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html Modulators HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html HYPERLINK https:/www.MedChemE

8、/Targets/VD/VDR.html & HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html HYPERLINK https:/www.MedChemE/Targets/VD/VDR.html Chemicals HYPERLINK https:/www.MedChemE/_24R_-MC-976.html (24R)-MC HYPERLINK https:/www.MedChemE/_24R_-MC-976.html HYPERLINK https:/www.MedChemE/_24R_-MC-976.html 976Cat. No.: H

9、Y-15267A HYPERLINK https:/www.MedChemE/_24S_-24,25-Dihydroxyvitamin-D3.html (24S)-24,25-Dihydroxyvitamin HYPERLINK https:/www.MedChemE/_24S_-24,25-Dihydroxyvitamin-D3.html HYPERLINK https:/www.MedChemE/_24S_-24,25-Dihydroxyvitamin-D3.html D3(24S)-24,25-Dihydroxycholecalciferol) Cat. No.: HY-15439(24

10、R)-MC 976 is a Vitamin D3 derivative.(24S)-24,25-Dihydroxyvitamin D3(24S)-24,25-Dihydroxycholecalciferol) is aninactive form of vitamin D3 which undergoesvarious levels of hydroxylation to form activevitamin D3 analogs.Purity: 98%Clinical Data: No Development ReportedSize: 1 mgPurity: 98.99%Clinical

11、 Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/_24s_-mc-976.html (24S)-MC HYPERLINK https:/www.MedChemE/_24s_-mc-976.html HYPERLINK https:/www.MedChemE/_24s_-mc-976.html 976 HYPERLINK https:/www.MedChemE/_24s_-mc-976.html HYPERLINK https:/www.MedChemE/11-hydroxysugiol.h

12、tml 11-HydroxysugiolCat. No.: HY-15267B Cat. No.: HY-107218(24S)-MC 976 is a Vitamin D3 derivative.11-Hydroxysugiol regulates the SUMOylation ofintracellular receptors by modulating RAR andvitamin D3 receptor (VDR).Purity: 98%Clinical Data: No Development ReportedSize: 1 mgPurity: 98%Clinical Data:

13、No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydroxy-VD2.html 1alpha, HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydroxy-VD2.html HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydroxy-VD2.html 24, HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydro

14、xy-VD2.html HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydroxy-VD2.html 25-Trihydroxy HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydroxy-VD2.html HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydroxy-VD2.html VD2 HYPERLINK https:/www.MedChemE/1alpha,-24,-25-Trihydroxy-VD2.html HYPERLINK

15、https:/www.MedChemE/1alpha-25-dihydroxy-vd2-13c2.html 1alpha, HYPERLINK https:/www.MedChemE/1alpha-25-dihydroxy-vd2-13c2.html HYPERLINK https:/www.MedChemE/1alpha-25-dihydroxy-vd2-13c2.html 25-Dihydroxy HYPERLINK https:/www.MedChemE/1alpha-25-dihydroxy-vd2-13c2.html HYPERLINK https:/www.MedChemE/1al

16、pha-25-dihydroxy-vd2-13c2.html VD2-13C2Cat. No.: HY-15156 Cat. No.: HY-15327S1alpha, 24, 25-Trihydroxy VD2 is a vitamin Danalog.1alpha, 25-Dihydroxy VD2-13C2 is the 13C-labeled1alpha, 25-Dihydroxy VD2-d6. 1alpha, 25-DihydroxyVD2-D6 is a deuterated form of vitamin D.Purity: 98.21%Clinical Data: No De

17、velopment ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/1alpha,-25-dihydroxy-vd2-d6.html 1alpha, HYPERLINK https:/www.MedChemE/1alpha,-25-dihydroxy-vd2-d6.html HYPERLINK https:/www.MedChemE/1alpha,-25-dihydroxy-vd2-d6.html 25-

18、Dihydroxy HYPERLINK https:/www.MedChemE/1alpha,-25-dihydroxy-vd2-d6.html HYPERLINK https:/www.MedChemE/1alpha,-25-dihydroxy-vd2-d6.html VD2-d6 HYPERLINK https:/www.MedChemE/1alpha,-25-dihydroxy-vd2-d6.html HYPERLINK https:/www.MedChemE/1alpha-hydroxy-vd4.html 1alpha-Hydroxy HYPERLINK https:/www.MedC

19、hemE/1alpha-hydroxy-vd4.html HYPERLINK https:/www.MedChemE/1alpha-hydroxy-vd4.html VD4Cat. No.: HY-15327(1-Hydroxy vitamin D4) Cat. No.: HY-132491alpha, 25-Dihydroxy VD2-D6 is a deuterated formof vitamin D.1alpha-Hydroxy VD4 , a 1alpha(OH)D derivative, caneffectively induce the differentiation ofmon

20、oblastic leukaemia U937, P39/TSU and P31/FUJcells.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.08%Clinical Data: No Development ReportedSize: 1 mg HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD2.html 24, HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD2.html HYPERL

21、INK https:/www.MedChemE/24,-25-Dihydroxy-VD2.html 25-Dihydroxy HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD2.html HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD2.html VD2 HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD2.html HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD3.html 24, HYPER

22、LINK https:/www.MedChemE/24,-25-Dihydroxy-VD3.html HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD3.html 25-Dihydroxy HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD3.html HYPERLINK https:/www.MedChemE/24,-25-Dihydroxy-VD3.html VD3(24,25-Dihydroxy vitamin D2) Cat. No.: HY-76801Cat. No.: HY-76915

23、24, 25-Dihydroxy VD2 is a hydroxylated metaboliteof Vitamin D2; a synthetic analog of Vitamin D.24, 25-Dihydroxy VD3 is a compound which isclosely related to 1,25-dihydroxyvitamin D3, theactive form of vitamin D3, but like vitamin D3itself and 25-hydroxyvitamin D3 is inactive as ahormone both in vit

24、ro and in vivo.Purity: 99.89%Clinical Data: No Development ReportedSize: 1 mg, 10 mgPurity: 98.60%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/24R-Calcipotriol.html 24R-Calcipotriol(PRI 2202; Impurity D

25、 of Calcipotriol) Cat. No.: HY-15266 HYPERLINK https:/www.MedChemE/25,26-dihydroxyvitamin-d3.html 25,26-Dihydroxyvitamin HYPERLINK https:/www.MedChemE/25,26-dihydroxyvitamin-d3.html HYPERLINK https:/www.MedChemE/25,26-dihydroxyvitamin-d3.html D3(25,26-Dihydroxycholecalciferol) Cat. No.: HY-1583024R-

26、Calcipotriol(PRI 2202) is an impurity ofCalcipotriol; Calcipotriol (MC 903; Calcipotriene)is a ligand of VDR-like receptors. IC50 value:Target: Vitamin D3 analog that displays minimaleffects on calcium homeostasis.25,26-DihydroxyvitaminD3(25,26-dihydroxycholecalciferol) is a metaboliteof vitamin D3

27、with intestinal calcium transportactivity.Purity: 98%Clinical Data: No Development ReportedSize: 1 mgPurity: 98.08%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/25-26-dihydroxyvitamin-d3-d3.html 25,26-Dihydroxyvitamin HYPERLINK https:/www.MedChemE/25-26-

28、dihydroxyvitamin-d3-d3.html HYPERLINK https:/www.MedChemE/25-26-dihydroxyvitamin-d3-d3.html D3-d3(25,26-Dihydroxycholecalciferol-d3) Cat. No.: HY-15830S HYPERLINK https:/www.MedChemE/25-hydroxy-vd2-d6.html 25-Hydroxy HYPERLINK https:/www.MedChemE/25-hydroxy-vd2-d6.html HYPERLINK https:/www.MedChemE/

29、25-hydroxy-vd2-d6.html VD2-d6Cat. No.: HY-1532825,26-Dihydroxyvitamin D3-d3(25,26-Dihydroxycholecalciferol-d3) is thedeuterium labeled 25,26-Dihydroxyvitamin D3.25-Hydroxy VD2-D6 is a labelled metabolite ofVitamin D2.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98.96%Clin

30、ical Data: No Development ReportedSize: 500 g, 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/3-o-_2-aminoethyl_-25-hydroxyvitamin-d3.html 3-O-(2-Aminoethyl)-25-hydroxyvitamin HYPERLINK https:/www.MedChemE/3-o-_2-aminoethyl_-25-hydroxyvitamin-d3.html HYPERLINK https:/www.MedChemE/3-o-_2-aminoethyl_

31、-25-hydroxyvitamin-d3.html D3(25-Hydroxy Vitamin D3 3,3-Aminopropyl Ether) Cat. No.: HY-15254 HYPERLINK https:/www.MedChemE/5-6-trans-vitamin-d3.html 5,6-trans-Vitamin HYPERLINK https:/www.MedChemE/5-6-trans-vitamin-d3.html HYPERLINK https:/www.MedChemE/5-6-trans-vitamin-d3.html D3(5,6-trans-Choleca

32、lciferol; 5,6-trans-Colecalciferol) Cat. No.: HY-15398A3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is aVitamin D3 derivative.5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct ofvitamin D3. Vitamin D3 is a naturally occuringform of vitamin D. Vitamin D3 induces c

33、elldifferentiation and prevents proliferation ofcancer cells.Purity: 99.73%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 99.44%Clinical Data: No Development ReportedSize: 5 mg HYPERLINK https:/www.MedChemE/Alfacalcidol.html Alfacalcidol HYPERLINK https:/www.MedChemE/Alfacalcid

34、ol.html HYPERLINK https:/www.MedChemE/Alfacalcidol-D6.html Alfacalcidol-d6(1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3) Cat. No.: HY-10003Cat. No.: HY-15332Alfacalcidol (1-hydroxycholecalciferol) is avitamin D active metabolites, acts as anon-selective VDR activator medication, andwidely be

35、 used in the management of osteoporosis.Alfacalcidol-D6, a deuterated Alfacalcidol(1-hydroxycholecalciferol; Alpha D3;1.alpha.-Hydroxyvitamin D3), is a non-selectiveVDR activator medication. IC50 value: Target: VDRactivator Alfacalcidol (1-hydroxycholecalciferol;Alpha D3; 1.alpha.Purity: 99.93%Clini

36、cal Data: LaunchedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98.0%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/alfacalcidol-d7.html Alfacalcidol-d7 HYPERLINK https:/www.MedChemE/alfacalcidol-d7.html (1-hydroxycholecalciferol-d7; HYPERLINK https:/www.MedChe

37、mE/Calcifediol.html Calcifediol1.alpha.-Hydroxyvitamin D3-d7) Cat. No.: HY-10003S (25-hydroxy Vitamin D3) Cat. No.: HY-32351Alfacalcidol-d7 (1-hydroxycholecalciferol-d7) isthe deuterium labeled Alfacalcidol. Alfacalcidol(1-hydroxycholecalciferol) is a vitamin D activemetabolites, acts as a non-selec

38、tive VDRactivator medication, and widely be used in themanagement of osteoporosis.Calcifediol (25-hydroxy Vitamin D3), a majorcirculating metabolite of vitamin D3, is a potentVDR inhibitor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.94%Clinical Data: LaunchedSize: 5 m

39、g, 100 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/Calcifediol-monohydrate.html Calcifediol HYPERLINK https:/www.MedChemE/Calcifediol-monohydrate.html HYPERLINK https:/www.MedChemE/Calcifediol-monohydrate.html monohydrate(25-hydroxy Vitamin D3 monohydrate) Cat. No.: HY-32351A HYPERLINK https:/www

40、.MedChemE/calcifediol-13c5-monohydrate.html Calcifediol-13C5 HYPERLINK https:/www.MedChemE/calcifediol-13c5-monohydrate.html HYPERLINK https:/www.MedChemE/calcifediol-13c5-monohydrate.html monohydrate(25-hydroxy Vitamin D3-13C5 monohydrate) Cat. No.: HY-32351AS1Calcifediol monohydrate (25-hydroxy Vi

41、tamin D3monohydrate), a major circulating metabolite ofvitamin D3, is a potent VDR inhibitor.Calcifediol-13C5 (25-hydroxy Vitamin D3-13C5)monohydrate is the 13C-labeled Calcifediolmonohydrate. Calcifediol monohydrate (25-hydroxyVitamin D3 monohydrate), a major circulatingmetabolite of vitamin D3, is

42、 a potent VDRinhibitor.Purity: 99.89%Clinical Data: LaunchedSize: 5 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/calcifediol-d3.html Calcifediol-d3(25-hydroxy Vitamin D3-d3) Cat. No.: HY-32351S HYPERLINK https:/www.MedChemE/calcifediol-d6.

43、html Calcifediol-d6Cat. No.: HY-13332Calcifediol-d3 is a deuterium labeled Calcifediol.Calcifediol, a major circulating metabolite ofvitamin D3, is a potent VDR inhibitor.Calcifediol-D6 is the deuterated form ofCalcifediol(25-hydroxy Vitamin D3), which is aprehormone that is produced in the liver by

44、hydroxylation of vitamin D3 (cholecalciferol) bythe enzyme cholecalciferol 25-hydroxylase IC50value: Target: This metabolite is beingPurity: 99.06%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98.39%Clinical Data: No Development ReportedSize: 500 g, 1 mg, 5 mg, 10 mg HYPERLINK

45、 https:/www.MedChemE/calcifediol-d6-monohydrate.html Calcifediol-d6 HYPERLINK https:/www.MedChemE/calcifediol-d6-monohydrate.html HYPERLINK https:/www.MedChemE/calcifediol-d6-monohydrate.html monohydrate(25-hydroxy Vitamin D3-d6 monohydrate) Cat. No.: HY-32351AS HYPERLINK https:/www.MedChemE/Calcipo

46、triol.html Calcipotriol(MC 903; Calcipotriene) Cat. No.: HY-10001Calcifediol-d6 (25-hydroxy Vitamin D3-d6)monohydrate is the deuterium labeled Calcifediolmonohydrate. Calcifediol monohydrate (25-hydroxyVitamin D3 monohydrate), a major circulatingmetabolite of vitamin D3, is a potent VDRinhibitor.Cal

47、cipotriol is a synthetic VitD analogue with a3high affinity for the vitamin D receptor.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.77%Clinical Data: LaunchedSize: 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/Calcipotriol-Impurity-C.html Calcipotriol HYPERL

48、INK https:/www.MedChemE/Calcipotriol-Impurity-C.html HYPERLINK https:/www.MedChemE/Calcipotriol-Impurity-C.html Impurity HYPERLINK https:/www.MedChemE/Calcipotriol-Impurity-C.html HYPERLINK https:/www.MedChemE/Calcipotriol-Impurity-C.html C HYPERLINK https:/www.MedChemE/Calcipotriol-Impurity-C.html

49、HYPERLINK https:/www.MedChemE/calcipotriol-impurity-c-d4.html Calcipotriol HYPERLINK https:/www.MedChemE/calcipotriol-impurity-c-d4.html HYPERLINK https:/www.MedChemE/calcipotriol-impurity-c-d4.html Impurity HYPERLINK https:/www.MedChemE/calcipotriol-impurity-c-d4.html HYPERLINK https:/www.MedChemE/

50、calcipotriol-impurity-c-d4.html C-d4Cat. No.: HY-75035 Cat. No.: HY-75035SCalcipotriol Impurity C is the impurity ofCalcipotriol, Calcipotriol is a ligand of VDR-likereceptors. Target: VDR.Calcipotriol Impurity C-d4 is the deuteriumlabeled Calcipotriol Impurity C. CalcipotriolImpurity C is the impur

51、ity of Calcipotriol,Calcipotriol is a ligand of VDR-like receptors.Purity: 99.20%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Calcipotriol-monohydrate.html Calcipotriol HYPERLINK ht

52、tps:/www.MedChemE/Calcipotriol-monohydrate.html HYPERLINK https:/www.MedChemE/Calcipotriol-monohydrate.html monohydrate HYPERLINK https:/www.MedChemE/Calcipotriol-monohydrate.html HYPERLINK https:/www.MedChemE/Calcitetrol.html CalcitetrolCat. No.: HY-10001A(1, 24, 25-Trihydroxy VD3) Cat. No.: HY-151

53、57Calcipotriol monohydrate is a synthetic VitD3analogue with a high affinity for the vitaminD receptor.Calcitetrol(1, 24, 25-Trihydroxy VD3) is thehormonally active form of vitamin D with threehydroxyl groups.Purity: 99.75%Clinical Data: LaunchedSize: 5 mg, 10 mg, 50 mg, 100 mgPurity: 98.83%Clinical

54、 Data: No Development ReportedSize: 1 mg, 5 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Calcitriol.html Calcitriol(1,25-Dihydroxyvitamin D3) Cat. No.: HY-10002 HYPERLINK https:/www.MedChemE/calcitriol-derivatives.html Calcitriol HYPERLINK https:/www.Med

55、ChemE/calcitriol-derivatives.html HYPERLINK https:/www.MedChemE/calcitriol-derivatives.html DerivativesCat. No.: HY-76802Calcitriol is the most active metabolite ofvitamin D and also a vitamin D receptor (VDR)agonist.Calcitriol Derivatives is a vitamin D3 analog. v.Purity: 99.81%Clinical Data: Launc

56、hedSize: 2 mg, 5 mg, 10 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-A.html Calcitriol HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-A.html HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-A.html Impur

57、ities HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-A.html HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-A.html A HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-A.html HYPERLINK https:/www.MedChemE/calcitriol-impurities-a-d6.html Calcitriol HYPERLINK https:/www.MedChemE/calcitriol-i

58、mpurities-a-d6.html HYPERLINK https:/www.MedChemE/calcitriol-impurities-a-d6.html impurities HYPERLINK https:/www.MedChemE/calcitriol-impurities-a-d6.html HYPERLINK https:/www.MedChemE/calcitriol-impurities-a-d6.html A-d6Cat. No.: HY-75041 Cat. No.: HY-75041SCalcitriol Impurities A is the impurity o

59、fCalcitriol, Calcitriol is the hormonally activeform of vitamin D, Calcitriol is the activemetabolite of vitamin D3 that activates thevitamin D receptor (VDR).Calcitriol impurities A-d6 is the deuteriumlabeled Calcitriol Impurities A.Purity: 99.51%Clinical Data: No Development ReportedSize: 1 mg, 5

60、mg, 10 mg, 25 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-D.html Calcitriol HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-D.html HYPERLINK https:/www.MedChemE/Calcitriol-Impurities-D.html Impurities HYPERLINK https:/ww