Parecoxib-SC-69124-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEParecoxibCat. No.: HY-17474CAS No.: 198470-84-7Synonyms: SC 69124分式: CHNOS分量: 370.42作靶點(diǎn): COX作通路: Immunology/Inflammation儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (134.98 mM)*

2、 means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.6996 mL 13.4982 mL 26.9964 mL5 mM 0.5399 mL 2.6996 mL 5.3993 mL10 mM 0.2700 mL 1.3498 mL 2.6996 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)

3、的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.75 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.75 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOL

4、OGICAL ACTIVITY物活性 Parecoxib是選擇性COX-2抑制劑。IC50 & Target COX-2戶使本產(chǎn)品發(fā)表的科研獻(xiàn) J Pharm Biomed Anal. 2018 May 22;158:1-7.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Ye Z, et al. Delayed administration of parecoxib, a specific COX-2 inhibitor, attenuated postischemic neuronal apopto

5、sis byphosphorylation Akt and GSK-3. Neurochem Res. 2012 Feb;37(2):321-9.2. Schr?der H, et al. Parecoxib and its metabolite valdecoxib directly interact with cannabinoid binding sites in CB1-expressing HEK 293cells and rat brain tissue. Neurochem Int. 2011 Jan;58(1):9-13.3. Guo YJ, et al. Analgesic effects of the COX-2 inhibitor parecoxib on surgical pain through suppression of spinal ERK signaling. Exp TherMed. 2013 Jul;6(1):275-279.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-37