國(guó)自然熱點(diǎn)帖

1、【2020年自然熱點(diǎn)自噬】1.2019年國(guó)自然中標(biāo)案例項(xiàng)目名稱：GPX4介導(dǎo)的細(xì)胞鐵死亡效應(yīng)在腎癌依維莫司獲得性耐藥中的作用機(jī)制研究（面上項(xiàng)目，南方醫(yī)科大學(xué)，55萬(wàn)元）關(guān)鍵詞：GPX4 ；細(xì)胞鐵死亡；腎癌；依維莫司；獲得性耐藥項(xiàng)目名稱:CaMKII介導(dǎo)的鐵死亡在碘造影劑腎病發(fā)生中的作用及機(jī)制研究面上項(xiàng)目，中南大學(xué)，55萬(wàn)元）關(guān)鍵詞：CaMKII ；鐵死亡；碘造影劑腎病項(xiàng)目名稱：PCDH20/SIRT1通過(guò)調(diào)節(jié)NRF2調(diào)控肝癌細(xì)胞鐵死亡的作用及分子機(jī)制研究（國(guó)青項(xiàng)目，鄭州大學(xué)，21萬(wàn)元）關(guān)鍵詞：PCDH20/SIRT1 ；細(xì)胞鐵死亡；NRF2 ；肝癌項(xiàng)目名稱：鴉膽子苦醇抑制CEP290/Nrf2

2、信號(hào)軸誘導(dǎo)黑素瘤細(xì)胞鐵死亡的機(jī)制研究（國(guó)青項(xiàng)目，重慶市中醫(yī)藥，21萬(wàn)元）關(guān)鍵詞：鴉膽子苦醇；鐵死亡；CEP290/Nrf2 ；黑素瘤項(xiàng)目名稱 基于ROS-GSTP1-GPX4信號(hào)軸誘導(dǎo)鐵死亡的級(jí)聯(lián)納米反應(yīng)器治療腫瘤轉(zhuǎn)移的研究（面上項(xiàng)目，上海交通大學(xué)，55萬(wàn)元）關(guān)鍵詞：ROS-GSTP1-GPX4 ；鐵死亡；級(jí)聯(lián)納米反應(yīng)器；腫瘤轉(zhuǎn)移項(xiàng)目名稱：HGF通過(guò)調(diào)控NRF2抑制鐵死亡改善酒精性心肌病心肌損傷的機(jī)制研究（國(guó)青項(xiàng)目，南京醫(yī)科大學(xué)，21萬(wàn)元）關(guān)鍵詞：鐵死亡；HGF ； NRF2 ；酒精性心肌?。恍募p傷項(xiàng)目名稱：AS斑塊鐵沉積誘導(dǎo)巨噬細(xì)胞Mox極化與鐵死亡及槲皮素干預(yù)的分子機(jī)制（面上項(xiàng)目，華中科

3、技大學(xué)，54萬(wàn)元）關(guān)鍵詞：巨噬細(xì)胞Mox極化；鐵死亡；AS斑塊鐵沉積；槲皮素干預(yù)項(xiàng)目名稱：PI3K/Akt/GSK3P通路調(diào)控Nrf2誘導(dǎo)視網(wǎng)膜色素上皮細(xì)胞鐵死亡的機(jī)制研究(國(guó)青項(xiàng)目，中南大學(xué)，21萬(wàn)元)關(guān)鍵詞：PI3K/Akt/GSK3P；上皮細(xì)胞鐵死亡；Nrf2 ；視網(wǎng)膜色素項(xiàng)目名稱：Lnc171816-BRG1交互作用調(diào)控肝細(xì)胞鐵死亡在移植肝缺血再灌注損傷中的作用及機(jī)制研究(面上項(xiàng)目，中山大學(xué)，55萬(wàn)元)關(guān)鍵詞：Lnc171816 ； BRG1 ；鐵死亡；移植肝缺血再灌注損傷項(xiàng)目名稱:成纖維樣滑膜細(xì)胞外泌體促進(jìn)軟骨細(xì)胞鐵死亡在骨關(guān)節(jié)炎中的作用及機(jī)制研究(國(guó)青項(xiàng)目，中國(guó)人民解放軍第二軍醫(yī)大

4、學(xué)，21萬(wàn) 元)關(guān)鍵詞：成纖維樣滑膜細(xì)胞外泌體；軟骨細(xì)胞鐵死亡；骨關(guān)節(jié)炎2、最新熱點(diǎn)高分文獻(xiàn)NRF2 Is a Major Target of ARF in p53-Independent TumorSuppression . ( Molecular Cell,2017 ) ( PMID : 28985506)ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway.(Nature cell biology,2019) (PMID:30962574)Inactiva

5、tion of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.(Nat.cell biol,2014)(PMID : 25402683)Annual Review of Cell and Developmental Biology Unconventional Ways to Live and Die: Cell Death and Survival inDevelopment,Homeostasis, and Disease.(Annu.Rev.Cell Dev.Biol,2018)(PMID : 30

6、089222)Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.(Nat.Chem. Biol. 2017 )(PMID : 27842066)Ferrous-Supply-Regeneration Nanoengineering for Cancer Cell Specific Ferroptosis in Combination with Imaging-Guided Photodynamic Therapy.(ACS Nano 2018 )(PMID : 30458111)JTC801 Induces p

7、H-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.(Gastroenterology 2018)(PMID : 29248440)Activation of the p62-Keap1-NRF2 Pathway Protects Against Ferroptosis in Hepatocellular Carcinoma Cells.(Hepatology 2016 )(PMID : 26403645)Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellatecells.(Autophagy 2018)(PMID : 30081711)A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitiv