胃酶抑素三氟醋酸鹽作用機(jī)制 - Medchemexpress - MCE中國(guó)

1、Product Data SheetPepstatin TrifluoroacetateCat. No.: HY-P0018A分式: CHFNO分量: 799.92Sequence: IsoValeryl-Val-Val-Sta-Ala-Sta-OHSequence Shortening: IsoVeryl-VV-Sta-A-Sta-OH作靶點(diǎn): Proteasome; HIV Protease作通路: Metabolic Enzyme/Protease; Anti-infection儲(chǔ)存式: Powder -80C 2 years-20C 1 yearIn solvent -80C 6 mo

2、nths-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 32 mg/mL (40.00 mM; Need warming)H2O : 0.1 mg/mL (insoluble)H2O : 2000 mg/kg for all species by oral route. Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats1.PROTOCOLCell Assay 2 Pepstatin A is freshly dissolved in DMSO

3、 at 7 mM. It is very slowly diluted (1:100) into the medium of HIV-infectedH9 suspension cultures so that no pepstatin A precipitated (final concentration, 70 M pepstatin A and 1% DMSO),and the cultures are incubated without change of culture medium for 48 hr. As control, uninfected H9 cells are als

4、oincubated with pepstatin and in addition HIV infected and uninfected cells are incubated with 1% DMSO but withoutpepstatin2.MCE has not independently confirmed the accuracy of these methods. They are for reference only.戶(hù)使本產(chǎn)品發(fā)表的科研獻(xiàn) Environ Sci Technol. 2017 Dec 5;51(23):13938-13948. Int J Antimicrob

5、 Agents. 2019 Dec;54(6):814-819. Toxicol Appl Pharmacol. 2018 Oct 1;356:159-171.Page 2 of 3 www.MedChemE Int J Oncol. 2019 Jul;55(1):331-339. Mol Med Rep. 2019 Jan;19(1):41-50.See more customer validations on HYPERLINK www.MedChemE www.MedChemEREFERENCES1. Umezawa H, et al. Pepstatin, a new pepsin i

6、nhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62.2. Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988Sep;85(18):6612-6.McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.Tel: 400-820-3792; 021-589559