Rooperol-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERooperolCat.No.:HY-119666CASNo.:83644-00-2分?式:C??H??O?分?量:282.29作?靶點(diǎn):Apoptosis;ReactiveOxygenSpecies;MDM-2/p53;Oct3/4作?通路:Apoptosis;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;StemCell/Wnt儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Rooperol?種Norlignan類(lèi)似物，具有抗腫瘤、抗炎和抗氧化活性。Rooperol通過(guò)線粒體誘導(dǎo)的ROS增加以及p53依賴(lài)性途徑觸發(fā)CSCs細(xì)胞凋亡，并通過(guò)下調(diào)?細(xì)胞關(guān)鍵調(diào)節(jié)因?(如Oct4、Nanog和Sox2)的表達(dá)，最終實(shí)現(xiàn)其抗癌效果[1][2][3][4]。REFERENCES[1].BoukesGJ,etal.Rooperolasanantioxidantanditsroleintheinnateimmunesystem:Aninvitrostudy[J].Journalofethnopharmacology,2012,144(3):692-699.[2].KabandaMM.AntioxidantactivityofrooperolinvestigatedthroughCu(IandII)chelationabilityandthehydrogentransfermechanism:aDFTstudy[J].Chemicalresearchintoxicology,2012,25(10):2153-2166.[3].GuzdekA,etal.Rooperol,aninhibitorofcytokinesynthesis,decreasestherespiratoryburstinhumanandratleukocytesandmacrophages[J].MediatorsofInflammation,1997,6(1):53-57.[4].AliAzouaouS,etal.SelectiveROS-dependentp53-associatedanticancereffectsofthehypoxosidederivativerooperolonhumanteratocarcinomalcancerstem-likecells[J].InvestigationalNewDrugs,2015,33:64-74.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: