細(xì)胞生物學(xué)：人基因組中7大類蛋白激酶

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人基因組中7大類蛋白激酶23

Kinasecascadethattransmitssignalsdownstreamfrom

activatedRasproteintoMAPkinaseMEK=MAPKKMAPK/ERK激酶4Inductionofgenetranscription

byactivatedMAPkinaseTCF:ternarycomplexfactor,三元復(fù)合物因子；SRF:serumresponsefactor5JAK-STAT信號(hào)轉(zhuǎn)導(dǎo)途徑6Twomechanismsforterminatingsignal

transductionfromtheerythropoietinreceptor(EpoR)SHP-1:含SH2的酪氨酸磷酸酶-1,SOCS:細(xì)胞因子信號(hào)轉(zhuǎn)導(dǎo)抑制蛋白7TGFβSmad信號(hào)轉(zhuǎn)導(dǎo)途徑8◆PhospholipaseCγisactivatedbysomeRTKs

andcytokinereceptors◆RecruitmentofPI-3kinasetohormone-stimulatedreceptorsleadstoactivation

ofproteinkinaseB◆ActivatedproteinkinaseBpromotescellsurvival

byseveralpathways◆TheinsulinreceptoractsthroughthePI-3

kinasepathwaytolowerbloodglucose

5.6.6PhosphoinositidesasSignal

Transducers9Thegenerationofinositol

phospholipiddockingsitesbyPI3-kinase10TherecruitmentofsignalingproteinswithPHdomainstotheplasmamembraneduringBcellactivation

PH:xxb血小板—白細(xì)胞C激酶底物同源域；BTK:Bruton

酪氨酸激酶11OnewayinwhichsignalingthroughPI3-kinasepromotescellsurvival12遍在蛋白參與的修飾與降解作用對(duì)信號(hào)轉(zhuǎn)導(dǎo)的影響13植物、原核生物、真菌的信號(hào)轉(zhuǎn)導(dǎo)特點(diǎn)14整聯(lián)蛋白參與的信號(hào)轉(zhuǎn)導(dǎo)15信號(hào)的脫敏16信號(hào)轉(zhuǎn)導(dǎo)小結(jié)G蛋白偶聯(lián)系統(tǒng)PKA途徑PKC途徑膜機(jī)器第二信使代謝效應(yīng)核效應(yīng)信號(hào)終止膜機(jī)器第二信使代謝效應(yīng)核效應(yīng)信號(hào)終止離子通道K離子通道光、cGMPcAMP游離PKA固定PKACBPCRECREBPKC效應(yīng)鈣離子效應(yīng)Tubby水解磷酸化抑制效應(yīng)物減量受體去敏17酶聯(lián)受體信號(hào)轉(zhuǎn)導(dǎo)基本特點(diǎn)膜機(jī)器二聚化自磷酸化接頭蛋白SH2,SH3結(jié)構(gòu)域效應(yīng)：細(xì)胞分裂酪氨酸激酶受體胰島素受體EFG受體與Ras其他