原發(fā)性高血壓患者靜息心率與高敏C反應(yīng)蛋白、內(nèi)皮素、靶器官損害的研究的論文

原發(fā)性高血壓患者靜息心率與高敏C反應(yīng)蛋白、內(nèi)皮素、靶器官損害的研究的論文 原發(fā)性高血壓患者靜息心率與高敏C反應(yīng)蛋白、內(nèi)皮素、靶器官損害的研究的論文AbstractObjective:Toinvestigatetherelationshipbetweenrestingheartrate(RHR)andhigh-sensitivityC-reactiveprotein(hs-CRP),endothelin(ET),andtargetorgandamageinpatientswithprimaryhypertension.Methods:Atotalof168patientswithprimaryhypertensionwereenrolledinthiscross-sectionalstudy.RHRwasmeasuredbyelectrocardiogram,andhs-CRPandETweremeasuredbyenzyme-linkedimmunosorbentassay.Targetorgandamagewasassessedbyechocardiography,carotidintima-mediathickness,andestimatedglomerularfiltrationrate.Results:ThemeanRHRwas72.5±9.8beats/min,andthemeanhs-CRPandETlevelswere3.8±3.7mg/Land3.1±1.8pg/mL,respectively.RHRwaspositivelycorrelatedwithhs-CRP(r=0.309,P<0.001)andET(r=0.283,P<0.001).Afteradjustingforpotentialconfoundingfactors,RHRremainedindependentlyassociatedwithhs-CRP(β=0.239,P=0.002)andET(β=0.176,P=0.027).Furthermore,RHRwaspositivelycorrelatedwithleftventricularmassindex(r=0.277,P<0.001)andcarotidintima-mediathickness(r=0.245,P=0.002),butnotwithestimatedglomerularfiltrationrate.Conclusion:RHRispositivelycorrelatedwithhs-CRP,ET,leftventricularmassindex,andcarotidintima-mediathicknessinpatientswithprimaryhypertension.ThesefindingssuggestthatRHRmaybeausefulmarkerforidentifyingpatientswithhypertensionwhoareatincreasedriskoftargetorgandamage.Keywords:restingheartrate,high-sensitivityC-reactiveprotein,endothelin,targetorgandamage,hypertension摘要目的：探討靜息心率（RHR）與高敏C反應(yīng)蛋白（hs-CRP）、內(nèi)皮素（ET）及靶器官損害在原發(fā)性高血壓患者中的關(guān)系。方法：本橫斷面研究納入168例原發(fā)性高血壓患者。使用心電圖測量RHR，采用酶聯(lián)免疫吸附法測量hs-CRP和ET。采用超聲心動圖、頸動脈內(nèi)膜-中膜厚度和估測腎小球?yàn)V過率評估靶器官損害。結(jié)果：平均RHR為72.5±9.8次/分鐘，平均hs-CRP和ET水平分別為3.8±3.7mg/L和3.1±1.8pg/mL。RHR與hs-CRP（r=0.309，P<0.001）和ET（r=0.283，P<0.001）呈正相關(guān)。在調(diào)整潛在混雜因素后，RHR仍獨(dú)立與hs-CRP（β=0.239，P=0.002）和ET（β=0.176，P=0.027）相關(guān)。此外，RHR與左心室質(zhì)量指數(shù)（r=0.277，P<0.001）和頸動脈內(nèi)膜-中膜厚度（r=0.245，P=0.002）呈正相關(guān)，但與估測腎小球?yàn)V過率無相關(guān)性。