2022-2023年河南省新鄉(xiāng)市公共英語五級(筆試)模擬考試(含答案)

2022-2023年河南省新鄉(xiāng)市公共英語五級(筆試)模擬考試(含答案)學校:________班級:________姓名:________考號:________

一、1.ListeningComprehension(15題)1.Strokevictimssometimesrefusetoregardtheirinjuredsidesaspartsoftheirbodiesbecausetheyareunwillingtoadmittheirdisabilities.

A.RightB.Wrong

2.聽力原文：Thehumannosehasgiventothelanguagesoftheworldmanyinterestingexpressions．Ofcourse，thisisnotsurprising．Withoutthenose，wecouldnotbreathenorsmell．Itisapartofthefacethatgivesapersonspecialcharacter．CyranodeBergeracsaidthatalargenoseshowedagreatmancourageous，courteous，manly，andintellectual．

Afamouswomanpoetwishedthatshehadtwonosestosmellarose!BlaisePascal，aFrenchphilosopher，madeaninterestingcommentaboutCleopatra'snose．Ifithadbeenshorter，hesaid，itwouldhavechangedthewholefaceoftheworld!

Historically，man'snosehashadaprincipalroleinhisimagination．Manhasreferredtothenoseinmanywaystoexpresshisemotions．Expressionsconcerningthenoserefertohumanweakness：anger，pride，jealousyandrevenge．

InEnglishthereareanumberofphrasesaboutthenose．Forexample，toholdupone'snoseexpressesabasichumanfeeling—pride．Peoplecanholduptheirnosesatpeople，things，andplaces．

Thephrase，tobeledaroundbythenose，showsman'sweakness．Apersonwhoisledaroundbythenoseletsotherpeoplecontrolhim．Ontheotherhand，apersonwhofollowshisnoseletshisinstinctguidehim．

Forthehumanemotionofrejection，thephrasetohaveone'snoseputoutofjointisverydescriptive．Theexpressionappliestopersonswhohavebeenturnedasidebecauseofarival．Theirprideishurtandtheyfeelrejected．Thisexpressionisnotnew．ItwasusedbyErasmusin1542．

ThisisonlyasamplingofexpressionsinEnglishdealingwiththenose．Thereareanumberofothers．However，itshouldbeasplainasthenoseonyourfacethatthenoseismorethananorganforbreathingandsmelling!

Whatisthispassagemainlyabout?

A.Thehumannoseasanorganforbreathingandsmelling.

B.Thenoseprovidinguswithvariousexpressions.

C.Awomanpoet'swishtohavetwonoses.

D.InterestingcommentsmadeonCleopatra'snose.

3.聽力原文：Todayit'smyturntogivetheweeklyoralpresentation,andthetopicthatProfessorMayhadassignedtomeis“thelifeofthepoet,EmilyDickinson”.ComparedwithWaltWhitmanwhomwediscussedlastweek.IfoundEmilyDickinsonstrikinglydifferent.SheseemedinfacttobethecompleteoppositeofWhitmaninherlifeandinherwork.Iwouldliketosharebrieflywiththeclasssomeoftheessentialfactsofherbiography.EmilyDickinsonwasbornin1830inAmherst,Mass,barelyadecadeafterWhitman.Inherearly20'sforreasonswhichstillremainamysteryshebegantowithdrawfromherordinarycontactwiththeworld.Fortheremaining30yearsofherlifeshewasseldomseenoutsideherhome.InthisrespectshewasquiteunlikeWhitmanwholovedthegreatoutdoors.EmilyDickinsonspenthersolitarydayscorrespondingwithherfriendsandwritinghundredsofremarkablepoems,notably“Iheardaflybuzz”andthepoemwehavereadfortoday“I'mnobody”.Althoughsheshowednoneofherpoemstoherfamilyandsentsomeofherletterstofriends.onlyfourwerepublishedinherlifetime.Mostofthem,almost1,200poemswerediscoveredinherroomaftershediedin1886attheageof56.Thesepoemshaveestablishedherasamajorpoet,andseveralmoderncriticsconsiderherthegreateStwomanpoetintheEnglishlanguage.Eh,that'saboutallIhave.Isthereanyquestion?Ifnot,weshouldprobablybegintalkingaboutDickinson's“I'mnobody”,thepoemProfessorMayassignedforthisweek'sclassdiscussion.

Whoisthespeaker?

A.Apoet.B.Ateacher.C.Astudent.D.Anartist.

4.聽力原文：Normallyastudentmustparticipateinacertainnumberofcoursesinordertograduate，andeachcoursewhichheattendsgiveshimacreditwhichhemaycounttowardsadegree．InmanyAmericanuniversitiesthetotalworkforadegreeismadeupofthirty-sixcourseseachlastingforonesemester．Atypicalcourseconsistsofthreeclassesperweekforfifteenweeks；whileattendingauniversityastudentwillprobablyattendfourorfivecoursesduringeachsemester．Normallyastudentwouldexpecttotakefouryearsattendingtwosemesterseachyear．Itispossibletospreadtheperiodofworkforthedegreeoveralongerperiod．Itisalsopossibleforastudenttomovebetweenoneuniversityandanotherduringhisdegreecourse，thoughthisisnotinfactdoneasaregularpractice．

Foreverycoursethathefollowsastudentisgivenagrade．whichisrecorded，andtherecordisavailableforthestudenttoshowtoprospectiveemployers．Allthisimposesaconstantpressureandstrainofwork，butinspiteofthissomestudentsstillfindtimeforgreatactivityinstudentaffairs．Electionstopositionsinstudentorganizationsarousemuchenthusiasm．Theeffectiveworkofmaintainingdisciplineisusuallyperformedbystudentswhoadvisetheacademicauthorities．Anystudentwhoisthoughttohavebrokentherules，forexample，bycheatinghastoappearbeforeastudentcourt．Withtheenormousnumbersofstudents，theoperationofthesystemdoesincludeacertainamountofactivity．Astudentwhohasheldoneofthesepositionsofauthorityismuchrespectedanditwillbeofbenefittohimlaterinhiscareer．

What'sthemainobjectiveofastudentwhoattendsacertainnumberofcourses?

A.Tograduateandobtainadegree.

B.Tolearnsomethingheisinterestedin.

C.Toavoidworking.

D.Toobeyhisparents'order.

5.Ifyoupokeyourtongueintoaholeofyourteeth,itfeelsverytinyandslim.

A.TrueB.Fasle

6.WhendidthisexpressioncomeintotheAmericanLanguage?

A.SometimeaftertheCivilWar．

B.DuringtheSecondWorldWar．

C.WhenpresidentGeorgeBushwasinoffice．

D.DuringtheperiodofIndependenceWar．

7.WhyareAmericanstudentsusuallyunderpressureofwork?

A.Becausetheiracademicperformancewillaffecttheirfuturecareerinthefuture.

B.Becausetheyareheavilyinvolvedinstudentaffairs.

C.Becausetheyhavetoobservetheuniversitydiscipline.

D.Becausetheywanttorunforpositionsofauthority.

8.Peoplelikethechangesintheorganizationofthecompany．

A.RightB.Wrong

9.Calories,naturalfood,mountainsandthedistancefrommoderncitiesaretheonlycommonthingsinthethreeregions.

A.TrueB.Fasle

10.Youcanfindyournoseinthedarknessbecauseofyour"feltimage".

A.TrueB.Fasle

11.Thepast-orientedpeopletendtolookattheworldina______．

12.Thespeakerwillintroducesixdepartmentalmanagersonebyone.

A.TrueB.Fasle

13.PartA

Directions:Youwillhearatalk.Asyoulisten,answerQuestions1-10bycirclingTRUEorFALSE.YouwillhearthetalkONLYONCE.Younowhave1minutetoreadQuestions1-10.

聽力原文：Hello,everyone.TodayIwillintroduceyouthelearningchainsinBritain.Herethechainsrefertoschoolslinkedtogetheraspartofagroup.Theycanofferstudentsmanypracticaladvantages.

Whenpeopleareaskedtonamealanguageschool,moreoftenthannot,theythinkofoneofthelargeinternationalchainsofschools.Somearevastlanguageteachingorganizationswithschoolsinmanydifferentcountriesandmayteachjustonelanguage.

Oneofthemainstrengthsofthesechainsisthefactthattheirnameisfamiliartopeopleallovertheworld.Thiscanbeabigadvantageintheconfusingworldoflanguagelearning.Moststudentsarebewilderedbymelargechoiceofschoolsandcoursesonoffer,bothathomeandabroad,andsomanyprefertochooseaschoolwhichhasafamiliarnameandanestablishedreputation.Chainschoolsknowthis,andpartoftheirsuccessisduetoeffectivemarketingandadvertising,whichhelpstokeeptheirnamewell-known.

Butchainschoolsshouldnotbedismissedbyseriousstudentsjustbecausetheyuseclevermarketingtechniques.Theyhaveotherimportantstrengthenswhichcanprovideadvantagestostudents.Aschoolisonlyasgoodasitsteachersandfacilities,andmanychainsofferveryhighstandardsinboth.Morechainsrequirethattheirteachershaveinternationallyrecognizedqualificationsandamaximumamountofteachingexperience.Itisimportantforchainstomaintainthesestandardsatallschools,becausethereputationofthewholechaincanbeaffectedifoneschoolperformsbadly.

Studentsalsobenefitfromthestandardizedstructureofchains.Mostchainsusethesametextbooksinalltheirschools,andoftentheyproducetheirowncourseworkmaterials.Theyalsoorganizetheircoursesinmesamewaywhichmeansthatstartingdatesandcourselengthsareusuallythesameatallschools.

Forstudents,oneofthemainadvantagesofthisstandardizedstructureissimplicity.IfyoucannotdecidewhethertostudyintheU.S.orBritain,forexample,mostchainsallowstudentstostarttheirlanguagecourseatoneschoolandcontinueatanother,sotheycanexperiencedifferentregionsordifferentcountries,aspartofthesamestudytrip.

Chainschoolstendtobelargerthansinglecenterschools,whichcanalsohaveadvantagesforstudents.Withlargernumbersofstudents,schooladministratorscanachieveabettermixtureofnationalitiesinclassrooms.Thismeansthatstudentscanavoidbeingwithotherstudentswhospeaktheirlanguage.Thisgivesthemthechancetomeetstudentsfromothercountries,andtopracticetheirEnglishwiththem.

Somechainsofferstudentsaverysimplebookingandenrolmentprocedurewhichisalsouseful.Applicationformsandenrolmentproceduresarethesameforallschools,sostudentsneedonlysupplytheirdetailsonce.

Studentsmayfindthattheycanbooktheircourseabroadthrougharepresentativeofachainschoolintheirowntownorcity.Otherchainsofferacentralizedbookingfacility,sostudentsonlyhavetocontactonecentertomakeabookinganywhereintheworld.

Chainschoolsoftenoperateindifferentlocations,whereasasingleschoolislikelytobebasedpermanentlyinonebuilding.Manychainschoolsoperatetemporaryschools,particularlyduringthesummerholidays.InBritain,theyoftenusesecondaryschoolpremiseswhichareemptyduringtheschoolholidays.

StudyingEnglishinanEnglish-speakingcountryisthemosteffectivewaytolearnthelanguage,butformanystudentsthisisonlyonestageoftheirlearningcareer.Moststudentsstartlearning

A.TrueB.Fasle

14.Whatwouldhappentoastudentifhisemployerreportshisimproperbehavior?

A.Hewouldbefired.

B.Hewouldnotgethispay.

C.Hewouldnotgetanotherjob.

D.Hewouldbefined.

15.Waterisasimportantasvitamins,mineralsandproteinsforlife.

A.RightB.Wrong

二、2.UseofEnglish(10題)16.(33)

17.(50)

18.(44)

19.

【C10】

20.(34)

21.

【C5】

22.

【C8】

23.(38)

24.

【C9】

25.(48)

三、3.ReadingComprehension(15題)26.

WhatdoestheauthorsayabouttheordinarypeopleintheThirdWorldcountries?

A.Theyarebeginningtorealizetheimportanceofenvironmentalprotection.

B.Theybelievethatmanychildrenarenecessaryforprosperity.

C.Theyarereluctanttoacceptadvicefromthegovernment.

D.Theythinkthatearningalivingismoreimportantthannatureconservation.

27.PartB

Directions:Inthefollowingarticlesomeparagraphshavebeenremoved.ForQuestions66-70,choosethemostsuitableparagraphfromthelistA-Ftofitintoeachofthenumberedgaps.Thereisoneparagraphwhichdoesnotfitinanyofthegaps.MarkyouranswersonANSWERSHEET1.

Itwasamomentmostbusinessexecutiveswouldpausetosavor:latelastyear,GermansportinggoodspioneerAdidaslearnedthatafteryearsofdecliningmarketshare,thecompanyhadsprintedpastU.S.ReebokInternationaltotakethesecondplacebehindNikeintheraceforworldwidesales.ButRobertLouis-Dreyfus,therumpledFrenchmanwhonowrunsAdidas,anddidn'tevenstopforoneofhistrademarkHavanacigarsincelebration,worriedthatthecompanywouldgrowcomplacent.Instead,heandagroupoffriendsboughtFrenchsoccerclubOlympicdeMarseille"Nowthat'ssomethingIhavedreamedaboutsinceIwasakid."Louis-Dreyfussayswithanadolescentgrin.

66.______

Withsalesinthefirstthreequartersof1996at$2.5billion,upablithering30.7%over1995,it'shardtorecallthedismalshapeAdidaswasinwhenLouis-DreyfustookoveraschairmaninApril1993.Foundedin1920byAdiDassler,theinventorofthefirstshoesdesignedespeciallyforsports,thecompanyenjoyedanearmonopolyinathleticshoesuntilanupstartcalledNikeappearedinthe1970sandrodetherunningfadtoriches.Bytheearly1990sAdidashadcomeunderthecontrolofFrenchbusinessmanBernardTapie,whowaslaterjailedforbribingthreeFrenchsoccerplayers.AlthoughthecompanytriedtospruceupitsstaidimagewithateamofAmericandesigners,Adidaslostmorethan$100millionin1992,promptingtheFrenchbanksthathadacquiredcontrolofthecompanyfromTapietobeginadesperatesearchforanewowner.

67.______

Thepoker-lovingLouis-Dreyfusknewhehadbeendealtawinninghand.FollowingtheleadsetbyNikeinthe1970s,hemovedproductiontolow-wagefactoriesinChina,IndonesiaandThailandandsoldAdidas'EuropeanfactoriesforatokenoneDeutschemarkapiece.HehiredPeterMoore,aformerproductdesigneratNike,ascreativedirector,andsetupstudiosinGermanyfortheEuropeanmarketandinPortland,Oregon,fortheU.S.Hethenriskedeverythingbydoublinghisadvertisingbudget."Wewentfromamanufacturingcompanytoamarketingcompany,"saysLouis-Dreyfus."Itdidn'ttakeagenius—youjusthadtolookatwhatNikeandReebokweredoing.Itwaseasierforsomeonecomingfromtheoutside,withnobaggage,todoit,thanforsomebodyfrominsidethecompany."

68.______

"ThemarketingatAdidasisvery,verygoodrightnow,"saysEugenioDiMaria,editorofSportingGoodIntelligence,anindustrynewsletterperceivingAdidasasaveryyoungbrand."Thecompanyisparticularlystronginapparel,muchstrongerthanNikeandReebok."

Although90%ofAdidasproductsforwearonstreetinsteadofsportsfields,Louis-DreyfusfeltthepreviousmanagementhadlostsightofAdidas'rootsasasportingproductscompany.Afterall,AdiDasslerinventedthescrew-instudforthesoccershoeandshodAmericanchampionJesseOwensinthe1936Olympics.Sohesoldofforfoldedothernon-corebrandsthatAdidashaddeveloped,includingLeCoqSportif,ArenaandPony.Europeisstillthecompany'slargestmarketbecauseAdidasdominatestheapparelindustryandthankstosoccer'smassivepopularitythere,Louis-Dreyfttsisquicktosharecreditfortheturnaroundwithasmallgroupoffriendswhoboughtthecompanywithhimin1993.OneofthosefellowinvestorsisaformerIMScolleague,ChristianTourres,nowsalesdirectoratAdidas."We'reprettycomplementarybecauseI'mabitofadreamer,soit'sgoodtohavesomebodyknockingonyourheadtoremindyouthere'sabudget,"saysLouis-Dreyfus.

Commutingtothefirm

28.

Accordingtothefirstparagraphofthepassage,theauthorconsiderswhichofthefollowingtobemosthelpfulindeterminingthevalueofspecialprotectivelaborlegislationforwomen?

A.Acomparativestudyofpatternsofwork-relatedillnessesinstatesthathadsuchlawsandinstatesthatdidnot.

B.Anestimateofhowmanywomenworkersareinfavorofsuchlaws.

C.Ananalysisofthecosttoemployersofcomplyingwithsuchlaws.

D.Anexaminationoftheactualeffectsthatsuchlawshavehadinthepastonwomenworkers.

29.(69)

30.

Fromthelastparagraphwecaninferthat______.

A.thegovernmenthopestosolvetheproblembywayofvolunteerrestrictions

B.morethan47millionAmericanswhoarequalifiedtogetfluvaccineshotscannotgetthemthisyear

C.Americahastodealwithalimitedsupplyoffluvaccinesthisyear

D.normallyonlyasmallpercentageofAmericanpopulationgetsfluvaccineshotseachyear

31.

Theword"tarnish"(line4,paragraph4)mostprobablymeans______.

A.affectB.warnC.troubleD.stain

32.PartC

Directions:Answerquestions71-80byreferringtothefollowinggames.

Note:AnswereachquestionbychoosingA,BorCandmarkitonANSWERSHEET1.Somechoicesmayberequiredmorethanonce.

Whichschool...

isnotforboys?71.______

haswonthenationalaward?72.______

ownsmostfull-timefacultymemberswhoholdaPh.D.orterminaldegreeintheirfield?

73.______

hasagoodreputationforwhattheydoforsomespecialpersons?74.______

hasalimitintheageforthosewhowillliveoncampus?75.______

putemphasisondevelopingstudentsverbaltalents?76.______

doesnotofferanyscholarships?77.______

providesstudentswithvocationaltraining?78.______

combinesliberalartswithprofessionalstudiesandpromotesservicetoothers?79.______

appliesadvanceddevicestoteaching?80.______

A

EllesmereCollegeisoneofthefastest-growingindependentschoolsinthecountryoverthepasttwoyears,withpupils'numberrisingbyalmost20%.Thegrowthhasledtoa$1millioninvestmentprogramin1999andthebuildingofanewlowerschoolforboysandgirlsagedninetothirteen.Thenewlowerschoolwillbethelargestsinglebuildingprojectatthecollegesinceitsfoundationin1884.

Intheseniorschool,two-thirdsofthepupilsareboarders,andboardingisavailablefromtheageof11.Thesixthform.isstrongwithover120pupils;thereisanexceptionallywide-rangeofA-levelsubjectsonofferandtheCollegehaspioneeredtheuseofvideoconferencingtechnologyasawayofimprovingitscurriculum.MicrosoftOfficequalificationsarealsoavailableinthesixthform.

TheCollegeissetinextensivegroundsinthebeautifulNorthShropshireLakeDistrict.Facilitiesareexcellentandvarious,andincludemanysportsfields,sixall-weathertenniscourts,indoorandoutdoorshootingranges,anine-holegolfcourseandapurpose-builttheater.TheCollegesailingclubhasboatswithinwalkingdistanceonWhitemere.

ThemajorityofthedaypupilsattheCollegeenjoytheCollegebusservicewhichcoversaverywidearea.BoardingthroughouttheSchoolhasbenefitedfromarecentmultimillionpoundrefurbishmentwhichhasdoneawaywithdormitoriesinfavorofmodern,comfortablerooms,thelargestsleepingsix,butmostsleepingtwoorone.

Academicstandardsarehighforaschoolwithabroadentryrange.Manyscholarshipsareawardedacrossarangeoftalents,buttheemphasisofanEllesmereeducationisfirmlyonbreadthwitheachpupilachievinghisorherfullpotential,whateverthatmaybe.Recentpupilsuccessesrangefrominternationalhonorsinshooting,fencingandcanoeingtoarecentleaver'selection—afteronlyoneyearasanundergraduate—toanExhibitioninchemistryatJesusCollege,Oxford.TheCollegehasanationalreputationforthequalityofitsdyslexiaprovision.

B

Thechoiceoftherightschoolforyoursonordaughterisimportant.Forover100yearsEdgehillCollegehasproudlypreparedindependently-mindedyoungpeopletotaketheirplaceinaworldofrapidlyadvancingtechnology.

Thefoundationsofasoundeducationarelaiddownearlyinlife.Edgehilldoesthiswithinthefriendlywallsofitsprepscho

33.Women'smindsworkdifferentlyfrommen's.Atleast,thatiswhatmostmenareconvincedof.Psychologistsviewthesubjecteitherasamatterorfrustrationorajoke.Nowthebiologistshavemovedintothisminefield,andsomeofthemhavefoundthattherearerealdifferencesbetweenthebrainsofmenandwomen.Butbeingdifferent,theypointouthurriedly,isnotthesameasbeingbetterorworse.

Thereis,however,adefinitestructuralvariationbetweenthemaleandfemalebrain.Thedifferenceisinapartofthebrainthatisusedinthemostcomplexintellectualprocesses—thelinkbetweenthetwohalvesofthebrain.

Thetwohalvesarelinkedbyatrunklineofbetween200and300millionnerves,thecorpuscallosum.Scientistshavefoundquiterecentlythatthecorpuscallosuminwomenisalwayslargerandprobablyricherinnervefibersthanitisinmen.Thisisthefirsttimethatastructuraldifferencehasbeenfoundbetweenthebrainsofwomenandmenanditmusthavesomesignificance.Thequestionis"What?",and,ifthisdifferenceexists,arethereothers?Re-searchshowsthatpresent-daywomenthinkdifferentlyandbehavedifferentlyfrommen.Aresomeofthesedifferencesbiologicalandinborn,aresultofevolution?Wetendtothinkthatistheinfluenceofsocietythatproducesthesedifferences.Butcouldwebewrong?

Researchshowedthatthesetwohalvesofthebrainhaddifferentfunctions,andthatthecorpuscallosumenabledthemtoworktogether.Formostpeople,thelefthalfisusedforwordhanding,analyticalandlogicalactivities;therighthalfworksonpictures,patternsandforms.Weneedbothhalvesworkingtogether.Andthebettertheconnections,themoreharmoniouslythetwohalveswork.And,accordingtoresearchfindings,womenhavethebetterconnections.

Butitisn'tallthateasytoexplaintheactualdifferencesbetweenskillsofmenandwomenonthisbasis.Inschoolsthroughouttheworldgirlstendtobebetterthanboysat"languagesubjects"andboysbetteratmathsandphysics.Ifthesedifferencescorrespondwiththedifferencesinthehemispherictrunkline,thereisanunalterabledistinctionbetweenthesexes.

Weshan'tknowforawhile,partlybecausewedon'tknowofanypreciserelationshipbetweenabilitiesinschoolsubjectandthefunctioningofthetwohalvesofthebrain,andwecannotunderstandhowthetwohalvesinter-actviathecorpuscallosum.Butthisstrikingdifferencemusthavesomeeffectand,becausethedifferenceisinthepartsofthebraininvolvedinintellect,weshouldbelookingfordifferencesinintellectualprocessing.

WhichofthefollowingstatementsisCORRECT?

A.Biologistsareconductingresearchwherepsychologistshavegivenup.

B.Braindifferencespointtosuperiorityofonesexovertheother.

C.Resultsofscientificresearchfailtosupportpopularbelief.

D.Thestructuraldifferenceinthebrainbetweenthesexeshaslongbeenknown.

34.

WhatdoestheauthorthinkofBotticelli'srepresentationskills?

A.Theyaretobefullyappreciated.

B.Theyevolvefromanuncertainsource.

C.Theyunderliehispersonality.

D.Theyconform.totheclassicalstyle.

35.

Thearticleconcludesthat______.

A.thecreationofjobsforallisanimpossibility

B.oureffortsandresourcesintermsoftacklingunemploymentareinsufficient

C.peopleshouldbeginsupportingthemselvesbylearningapracticalskill

D.weshouldhelpthosewhosejobsareonlypart-time

36.

Ed'sencounterwiththerecyclingteamshowsthat______.

A.Edwasdesperatetocorrecthismistake.

B.EdonlywantedtogivemoneytoRaoul.

C.Edwasunwillingtotipthetruckdriver.

D.Ednolongerwantedtogivethemmoney.

37.(68)

38.(72)

39.At18,AshanthiDeSilvaofsuburbanClevelandisalivingsymbolofoneofthegreatintellectualachievementsofthe20thcentury.Bornwithanextremelyrareandusuallyfataldisorderthatleftherwithoutafunctioningimmunesystem(the"bubble-boydisease",namedafteranearliervictimwhowaskeptaliveforyearsinasterileplastictent),shewastreatedbeginningin1990witharevolutionarynewtherapythatsoughttocorrectthedefectatitsverysource,inthegenesofherwhitebloodcells.Itworked.Althoughherlastgene-therapytreatmentwasin1992,sheiscompletelyhealthywithnormalimmunefunction,accordingtooneofthedoctorswhotreatedher,W.FrenchAndersonoftheUniversityofSouthernCalifornia.Researchershavelongdreamedoftreatingdiseasesfromhemophiliatocancerbyreplacingmutantgeneswithnormalones.Andthedreamingmaycontinuefordecadesmore."Therewillbeagene-basedtreatmentforessentiallyeverydisease,"Andersonsays,"within50years."

It'snotentirelyclearwhymedicinehasbeensoslowtobuildonAnderson'searlysuccess.TheNationalInstitutesofHealthbudgetofficeestimatesitwillspend$432millionongene-therapyresearchin2005,andthereisnoshortageofpromisingleads.Thetherapeuticgenesareusuallydeliveredthroughvirusesthatdon'tcausehumandisease."ThevirusissortoflikeaTrojanhorse,"saysRonaldCrystalofNewYorkPresbyterian/WeillCornellMedicalCollege."Thecargoisthegene."

AttheUniversityofPennsylvania'sAbramsohCancerCenter,immunologistCarlJunerecentlytreatedHIVpatientswithageneintendedtohelptheircellsresisttheinfection.AtCornellUniversity,researchersarepursuinggene-basedtherapiesforParkinson'sdiseaseandararehereditarydisorderthatdestroyschildren'sbraincells.AtStanfordUniversityandtheChildren'sHospitalofPhiladelphia,researchersaretryingtofigureouthowtohelppatientswithhemophiliawhotodaymustinjectthemselveswithexpensiveclottingdrugsforlife.Animalexperimentshaveshowngreatpromise.

Butsomehow,thingsgetlostinthetranslationfromlaboratorytopatient.Inhumantrialsofthehemophiliatreatment,patientsshowaresponseatfirst,butitfadesovertime.Andthefieldhasstillnotrecoveredfromthesetbackitsufferedin1999,whenJesseGelsinger,an18-year-oldwithararemetabolicdisorder,diedafterreceivinganexperimentalgenetherapyattheUniversityofPennsylvania.Someexpertsworrythatthefieldwillbetarnishedfurtherifthenextpeopletobenefitarenotpatientsbutathletesseekinganedge.Thissummer,researchersattheSalkInstituteinSanDiegosaidtheyhadcreateda"marathonmouse"byimplantingagenethatenhancesrunningability;already,officialsattheWorldAnti-DopingAgencyarepreparingtotestathletesforsignsof"genedoping".Buttheprincipleisthesame,whetheryou'retryingtohelpahealthyrunnerrunfasterorallowamuscular-dystrophypatienttowalk."Everybodyrecognizesthatgenetherapyisaverygoodidea,"saysCrystal."Andeventuallyit'sgoingtowork."

ThecaseofAshanthiDesilvaismentionedinthetextto______.

A.showthepromiseofgene-therapy

B.giveanexampleofmoderntreatmentforfataldiseases

C.introducetheachievementofAndersonandhisteam

D.explainhowgene-basedtreatmentworks

40.

Theenclosuresofthe17thand18thcenturiesmeantthat______.

A.peoplewerenolongerlegallyentitledtoownland

B.peo