Piracetam-UCB-6215-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPiracetamCat. No.: HY-B0585CAS No.: 7491-74-9Synonyms: UCB-6215分式: CHNO分量: 142.16作靶點: iGluR作通路: Membrane Transporter/Ion Channel; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗

2、DMSO : 100 mg/mL (703.43 mM)H2O : 50 mg/mL (351.72 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 7.0343 mL 35.1716 mL 70.3433 mL5 mM 1.4069 mL 7.0343 mL 14.0687 mL10 mM 0.7034 mL 3.5172 mL 7.0343 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實

3、驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (17.59 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)1/2 Master of Small Molecules

4、您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (17.59 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Piracetam (UCB-6215)GABA的環(huán)狀衍物，可作于多種認知障礙。體外研究 Piracetam (UCB-6215) is able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42,in a concentration-dependent manner. Preincubation of pi

5、racetam, at a piracetam/peptide ratio of 960, during20 min before the addition of Abeta 29-42 prevents almost completely the mixture of the two fluorescentprobes. Preincubation of piracetam with lipids prevents almost completely the release of calcein induced bythe peptide in a dose-dependent fashio

6、n (piracetam/peptide ratios from 9.6 to 960) 1.體內(nèi)研究 Piracetam (UCB-6215) ( 2. Piracetam (UCB-6215) (300 mg/kg daily for 6 weeks) improves active avoidancelearning in the aged rats only and elevates membrane fluidity in all brain regions except the cerebellum in theaged rats. Piracetam (UCB-6215) (30

7、0 mg/kg daily for 6 weeks) also improves NMDA receptor density in thehippocampus and on muscarinic cholinergic receptor densities in the frontal cortex and the striatum and to alesser extent in the hippocampus of rats 3.REFERENCES1. Mingeot-Leclercq, M.P., et al., Piracetam inhibits the lipid-destab

8、ilising effect of the amyloid peptide Abeta C-terminal fragment. BiochimBiophys Acta, 2003. 1609(1): p. 28-38.2. Muller, W.E., et al., Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain. Biochem Pharmacol, 1997.53(2): p. 135-40.3. Scheuer, K., et al., Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain.Pharmacopsychiatry, 1999. 32 Suppl 1: p. 10-6.McePdfHeightCaution: Product has not been fully validated for medical appli