Safinamide-EMD-1195686-DataSheet-生命科學試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESafinamideCat. No.: HY-70057CAS No.: 133865-89-1Synonyms: EMD 1195686; FCE 26743分式: CHFNO分量: 302.34作靶點: Monoamine Oxidase作通路: Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO

2、 : 100 mg/mL (330.75 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.3075 mL 16.5377 mL 33.0753 mL5 mM 0.6615 mL 3.3075 mL 6.6151 mL10 mM 0.3308 mL 1.6538 mL 3.3075 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當?shù)娜芙獍?，配制前請先配制澄清的儲備液，?/p>

3、依次添加助溶劑(為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當天使；澄清的儲備液可以根據(jù)儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.75 mg/mL (9.10 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.75 mg/mL (9.10 mM); Clear solution1/2 Master of

4、 Small Molecules 您邊的抑制劑師www.MedChemE3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.75 mg/mL (9.10 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Safinamide (EMD 1195686; FCE 26743)可逆的MAO-B抑制劑，IC50為98 nM，對MAO-A的抑制性5918倍。REFERENCES1. Leonetti F, et al. Solid-phase synthesis and insights into structure-ac

5、tivity relationships of safinamide analogues as potent and selectiveinhibitors of type B monoamine oxidase. J Med Chem, 2007, 50(20), 4909-4916.2. Schapira AH. Safinamide in the treatment of Parkinsons disease. Expert Opin Pharmacother. 2010 Sep;11(13):2261-8.3. Onofrj M, et al. An expert opinion on

6、 safinamide in Parkinsons disease. Expert Opin Investig Drugs. 2008 Jul;17(7):1115-25.4. Chazot PL. Safinamide for the treatment of Parkinsons disease, epilepsy and restless legs syndrome. Curr Opin Investig Drugs. 2007Jul;8(7):570-9.5. Dal Bo L, et al. Bioassay of safinamide in biological fluids of humans and various animal species. Arzneimittelforschung.2006;56(12):814-9. /pubmed/17260668McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Te