Doramectin - Parasite 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDoramectinCat. No.: HY-17035CAS No.: 117704-25-3分式: CHO分量: 899.11作靶點(diǎn): Parasite作通路: Anti-infection儲(chǔ)存式: -20C, protect from light* In solvent : -80C, 6 months; -20C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (55.61 mM)*

2、means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.1122 mL 5.5611 mL 11.1221 mL5 mM 0.2224 mL 1.1122 mL 2.2244 mL10 mM 0.1112 mL 0.5561 mL 1.1122 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作

3、液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (2.78 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (2.78 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑

4、師www.MedChemE物活性 Doramectin具有抗寄活性。REFERENCES1. Davey RB, Pound JM, Klavons JA, Lohmeyer KH, Freeman JM, Olafson PU.Analysis of doramectin in the serum of repeatedly treatedpastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion.Exp Appl Acarol. 20

5、12 Apr;56(4):365-74. doi: 10.1007/s10493-012-9525-1.2. Wang XJ, Zhang J, Wang JD, Huang SX, Chen YH, Liu CX, Xiang WS.Four new doramectin congeners with acaricidal and insecticidalactivity from Streptomyces avermitilis NEAU1069.Chem Biodivers. 2011 Nov;8(11):2117-25. doi: 10.1002/cbdv.201000295.3. S

6、arre C, Claerebout E, Vercruysse J, Levecke B, Geldhof P, Pardon B, Alvinerie M, Sutra JF, Geurden T.Doramectin resistance inHaemonchus contortus on an alpaca farm in Belgium.Vet Parasitol. 2012 Apr 30;185(2-4):346-51.4. Lobetti R.Successful resolution of oesophageal spirocercosis in 20 dogs followi

7、ng daily treatment with oral doramectin.Vet J. 2012Jul;193(1):277-8.5. Wang JB, Pan HX, Tang GL.Production of doramectin by rational engineering of the avermectin biosynthetic pathway.Bioorg Med ChemLett. 2011 Jun 1;21(11):3320-3.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use