腸道真菌和病毒在酒精相關(guān)性肝病的作用-國際臨床研究雜志

【關(guān)鍵詞】酒精相關(guān)性肝病（ALD）；腸道真菌；腸道病毒；腸道微生【Abstract】Alcohol-relatedliverdiseaseisaffectingpeople'squalityoflife.Therefore,thestudyofalcohol-relatedliverdiseaseneedspathogenesisandprognosisarenotclear.Intestinalmicroecologyisaresearchhotspotinremicroecologyplaysanimportantroleintheoccurrenceanddevelopmentofalcohol-relatedliverdisease.Aofstudieshavefoundthatintestinalflora,dominatedbybacteria,isrelatedtothepathogenesisofalcohodisease.LessresearcvirusesandhumanoranimalhealthanddiseasesathomeandabroadanddistributionofintestinalfungiandenteroviruseswerandenterovirusesandALD,soastofindnewtherapeutictargetsandprovidenewALD.【Keywords】Alcohol-relatedliverdisease(ALD);Intestinalfungi;Enterovirus;Gutmicrobes;Enteroh與酒精相關(guān)的肝癌患者死亡約占肝癌總死亡人數(shù)的腸-肝軸作為非真實存在的代謝器官，通過物質(zhì)代進一步檢查了兩種豐富的真菌，釀酒酵母和白色念珠床對照試驗中，收集酒精使用障礙者（alcoholuse伊薩酵母屬（Issatchenkia）、白念珠菌屬（Candida后其肝功能改善的水平與腸道念珠菌和馬拉色菌豐度患者預(yù)后的治療靶點，需要進一步研究來驗證這一觀釀酒酵母抗體（Anti-SaccharomycesCerevisiaeAnti-后，后者血清IL-1β水平顯著降低，進一步分析提示度增加，細小病毒科（Parvoviridae）和皰疹病毒科部分病毒與ALD進展相關(guān)，葡萄球菌噬菌體腸道病毒可能通過與腸道菌群的多重相互作用來說明噬菌體可以調(diào)節(jié)粘膜免疫來影響宿主健康及疾病常規(guī)使用改善肝功能藥物是目前常規(guī)治療手段。對于對于肝硬化失代償期患者，可利福昔明抗感染治露的小鼠中給予抗真菌藥物可以減少腸道真菌的過度epidemiologyofalcohol-associatedcirrhosisandHCC:trends,projectionsandriskfactors[J].NatRevGastroenterolHepatol,2023,20(1):37-contributingtoalco[3]AlbillosA,DeGottardiA,RescignoM.Thegut-liveraxisinliverdisease:PathophysEndotoxemia,andTheirRelatiMicrobiotaCompositioninAlcohoAlcoholClinExpRes,2018,42(12):2313-23microbiotachangesassociatedwithchronicadministrationinmice[J].Gu[7]BajajJS.Alcohol,liveNatRevGastroenterolHepatol,[8]LangS,SchnablB.MMicrobe,2020,28(2):233-MicrobiomeAxisinHealthandDiseasePeayKG,KenfbiodiversityintheEarthmmycobiomeoftheHumanMicrobiomeProjecthealthyfungiofthehumangutmicrobiome:correlationswithdietandbacterialresidents[J].PLoSOne,2013,8(6):interkingdommicrobialcommunitiesintheprimordialInvestigatingColonizationoftheHealthyAdultGastrointestinalTractbyFungi[J].mSphere,2018,3(2FungalMicrobiomeinAlcoholUseDisorder[J].FrontandSystemicImmuneResponsetoFungAlcoholicHepatitis[J].Hepatology,2020,contributetodevelopmentofalcoholiclivamelioratesinflammasome-dependentsteatohepatitisinmice[J]Nature,2016,532(759gutmicrobiotabypolysaccharidesofWolfiporiacocosrevealsthecontributionofthegutfungi-inducedPGEHumanGutViromIndividualSpecific[J].CellHostMicrobe,20527-541e5.[26]GregoryAC,ZablockiO,ZayedAA,etal.TheGDatabaseRevealsAge-DependentPatternsofVirome28(5):724-740e8.Metagenomics,RelationswithHumanDiseases,andTherapeuticApplicatioHerpesvirusesIncreasetheSeverityofHepatitis[J].ofhumanherpesvirustype8alreadchronichepatitisbeforethedevelopmentofcir[31]ChouAL,HuangWW,TsaoSM,etal.Humanhetype8inpatientswithcirrhosis:correlaalcoholism,hepatithrombocytopenia[J].AmJClinPathol,2008,130(2):associatedwithahigherChild-PughscoreandmaypredictpoorprognosesforpatientswithlBacteriophages,CommensalImmunity[J].TrendsMicrobiol,[34]BajajJS,SikaroodiM,ShamsaddiniA,etal.Interactionofbacterialmetagenomeandviromeinpatieandhepaticencepsafetyrequirementsforsustainablephagetherproducts[J].PharmRes,2015,32(7):2173-9.[36]CheroutreH,MadakamutilL.memoryTcellsjoinforcesatthemucosalfronRevImmunol,2004,4(4):290-3intestinalintraepitheliallymphocytBacteriophagesIsLinkedtoAggravatedIntestinalInflammationandColitis[J].CellHostMicrobe25(2):285-299e8.[40]EuropeanAssociationAddressEEE,EuropeanAssociationfortheStudyofTheL.EASLClinicalPracticeGuidelinesforthemanofpatientswithdecompensatedcirrhosis[J].JHepatol,preventscomplicatiowithdecompensatedlivpatientswithrefractorytypeascites][J].ZhonghuaGan[43]FujimotoY,KajiK,Nizincacetateandrifaxliverfibrosisbymaintainingintestinalbboulardii:WhatMakesItTickasSuccessfulProJFungi(Basel),2020,6(2).[45]Kazmierczak-SiedleckaK,RuszkowskiSaccharomycesboulardiiCNCMI-745:MicroorganismUsedasProbioticAgenTreatmentofSelectedDisealleviatesulcerativecolitisrebalanci