CD白細(xì)胞分化抗原細(xì)胞膜表面分化抗原群地定義及意義

CD/白細(xì)胞分化抗原/細(xì)胞膜表面分化抗原群的定義及意義CD（Clusterofdifferentiation）就是細(xì)胞膜表面的分化抗原群/分化抗原簇，應(yīng)用聚類分析，可將來自不同實驗室識別同一分化抗原的單克隆抗體歸為一種CD，經(jīng)由從1982年第1次國際上人類白細(xì)胞分化抗原會議（TheHumanLeucocyteDifferentiationAntigenworkshop，HLDA）統(tǒng)一命名。迄今為至，人CD的序號已從CD1命名至CD350()，可大致劃分為T細(xì)胞、B細(xì)胞、髓細(xì)胞、NK細(xì)胞、血小板、粘附分子、內(nèi)皮細(xì)胞、細(xì)胞因子受體、激活抗原、碳水化合物半抗原、樹突狀細(xì)胞、干細(xì)胞／祖細(xì)胞、基質(zhì)細(xì)胞和紅細(xì)胞14個組。白細(xì)胞分化抗原（LeucocyteDifferentiationAntigen，LDA）是指不同譜系(1ineage)血細(xì)胞在正常分化，成熟，活化過程中出現(xiàn)或消失的細(xì)胞表面標(biāo)志，多是跨膜蛋白或糖蛋白，少數(shù)為碳水化合物半抗原。隨著人類功效基因組計劃研究以及免疫學(xué)與其它學(xué)科的交叉，人類白細(xì)胞分化抗原的概念逐步被人類細(xì)胞分化分子(HCDM)所替代。采用單克隆抗體鑒定辦法識別的白細(xì)胞分化抗原又稱CD（clusterofdifferentiation）抗原。檢測CD抗原是實驗室識別細(xì)胞及不同分化階段細(xì)胞或細(xì)胞亞群最重要的辦法。白細(xì)胞分化抗原（狹義上的CD）參加機(jī)體重要的生理和病理過程：①免疫應(yīng)答過程中免疫細(xì)胞的互相識別，免疫細(xì)胞抗原識別、活化、增殖和分化，免疫效應(yīng)功效的發(fā)揮；②造血細(xì)胞的分化和造血過程的調(diào)控；③參加炎癥反映、血栓形成和組織修復(fù)；④參加細(xì)胞的生長、分化、遷移，及腫瘤的惡化和轉(zhuǎn)移。CD在基礎(chǔ)免疫學(xué)研究中重要應(yīng)用于：①CD抗原的基因克隆，新CD抗原及新配體的發(fā)現(xiàn)；②CD抗原構(gòu)造與功效關(guān)系；③細(xì)胞激活途徑和膜信號的傳導(dǎo)；④細(xì)胞分化過程中的調(diào)控；⑤細(xì)胞亞群的功效。CD在臨床免疫學(xué)研究中重要用于：①機(jī)體免疫功效的檢測；②白血病、淋巴瘤免疫分型；③免疫毒素用于腫瘤治療、骨髓移植以及移植排斥反映的防治；④體內(nèi)免疫調(diào)節(jié)治療。在許多場合下，抗體及其識別的對應(yīng)抗原都用同一種CD序號，因此在參閱教科書和文獻(xiàn)時需加注意：(1)CD是流水編號，CD129暫缺；CD67和CD66b是重復(fù)的；CD187-190，CD211，CD237，CD341-343，CD345-248暫未編號。(2)CD中帶有w的抗原或抗體CDw12，CDw198，CDw199，CDw293尚需繼續(xù)進(jìn)行全方面鑒定。(3)有些CD抗原又可進(jìn)一步劃分為不同的組員，普通用小寫英文字母表達(dá)，但狀況有所不同：①如CD1可分為CD1a，CD1b和CD1c，這三種不同分子是分別由三個不同的高度同源的基因所編碼；②CD45最少可分為CD45RA，CD45RB，CD45RC和CD45RO，它們是同一基因的不同異型/同種型（isoform）；③CD2和CD2R是識別同一種分子上不同的表位；④CD49已進(jìn)一步劃分為CD49a，D49b，CD49c，CD49d，CD49e和CD49f，它們的基因定位于不同的染色體上，但含有較高的同源性。（4）CD的組劃分的特異性是相對的，事實上，許多CD抗原的組織細(xì)胞分布較為廣泛。另外，有的CD抗原可由不同的分類角度而歸入不同的組，如IL-2受體a鏈CD25是活化T細(xì)胞的標(biāo)記，也屬于細(xì)胞因子受體；再如某些屬于T細(xì)胞、B細(xì)胞、髓細(xì)胞或NK細(xì)胞組的CD抗原事實上也是粘附分子，等等。CD

重要抗原體現(xiàn)(MainAntigenExpression)/其它名字/分子量(kDa)CD1aCorticalThymocytes(stg),Bcellsubset,Dendriticcells,Langerhanscells49,12

CD1bCorticalThymocytes(mod),Bcellsubset,Dendriticcells,Langerhanscells45,12

CD1cCorticalThymocytes(weak),Bcellsubset,Dendriticcells,Langerhanscells43,12

CD2

Tcells,NKcellsLFA-2,E-RosetteReceptor50

CD2RActivatedTcells50

CD3Tcells16,20,25-28

CD4Helper-inducerTcells,Monocytes,Macrophages56

CD5Tcells,Bcellsubset67

CD6Tcells,Bcellsubset105

CD7Tcells40

CD8Cytotoxic/SuppressorTcells,NKcells32-34

CD9Platelets,Monocytes,Pre-Bcells24

CD10Pre-Bcells,GranulocytesCALLA100

CD11aLeukocytesLFA-1,αLIntegrin180

CD11bGranulocytes,Monocytes,NKcellsMAC-1,αMIntegrin,CR3170

CD11cGranulocytes,Monocytes,NKcells,Tcellsubset,Bcellsubset,αXIntegrin150

CDw12Granulocytes,Monocytes90-120

CD13Granulocytes,MonocytesAminopeptidaseN130

CD14Monocytes55

CD15Granulocytes,MonocytesLewisXCHO

CD15sNeutrophilsSialylLewisXCHO

CD15uMyeloidsubsetSulfatedLewisXCHO

CD16aNKcells,MacrophagesFcRIIIA50-65

CD16bGranulocytesFcRIIIB48

CD17Granulocytes,Monocytes,PlateletsLactosylceramide-

CD18Leukocytes(Plateletsnegative)β2Integrin95

CD19Bcells90

CD20Bcells33,35,37

CD21Bcellssubset,FolliculardendriticcellsCR2145

CD22Bcells140

CD23Bcellsubset,Eosinophils,PlateletsFcεRII50-45

CD24Bcells,Granulocytes41/38

CD25ActivatedTcellsIL-2RαChain55

CD26Tcellsubset,Macrophages110

CD27Tcellsubset55

CD28Tcellsubset44

CD29Leukocytesβ1Integrin130

CD30ActivatedTandBcells,ReedSternbergcellsKi-1105

CD31Platelets,Monocytes,Granulocytes,BcellsPECAM-1,GPIIa140

CD32Monocytes,Neutrophils,Bcells,EosinophilsFcRII40

CD33MyeloidProgenitorcells,Monocytes67

CD34HematopoieticProgenitorcells105-120

CD35Monocytes,Bcells,GranulocytesCR1160,190,220,250

CD36Monocytes,PlateletsGPIV(IIIb)88

CD37Bcells52-40

CD38ActivatedTcells,Plasmacells45

CD39Bcells,Monocytes100-70

CD40Bcells,Monocytes,Carcinomacells48/44

CD41Platelets,MegakaryocytesGPIIb/IIIa,αIIbIntegrin120

CD42aPlatelets,MegakaryocytesGPIX23

CD42bPlatelets,MegakaryocytesGPIB-a135,23

CD42cPlatelets,MegakaryocytesGPIB-b22

CD42dPlatelets,MegakaryocytesGPV85

CD43Tcells,Granulocytes,Monocytes

Leukosialin90-100

CD44Leukocytes,ErythrocytesH-CAM,Pgp-18-90

CD44R(Varied-dependentuponExonSplicing)

CD45LeukocytesLeukocyteCommonAntigen180,190,205,220

CD45RABcells,Tcellsubset,Monocytes220,205

CD45RBBcells,Tcellsubset,Monocytes190,205,220

CD45RCBcells,Tcellsubset190,205,220

CD45ROBcells,Tcellsubset,Monocytes180

CD46Ubiquitous(Erythrocytesnegative)MembraneCofactorProtein66,56

CD47Ubiquitous47-52

CD47RBroad47-52

CD48Leukocytes43

CD49aActivatedTcellsVLA-1,α1Integrin210

CD49bBcells,Monocytes,PlateletsVLA-2,α2Integrin160

CD49cBcellsVLA-3,α3Integrin125

CD49dLymphocytes,Monocytes,EosinophilsVLA-4,α4Integrin150,80,70

CD49eTcellsubset,Monocytes,PlateletsVLA-5,α5Integrin132/25

CD49fTcellsubset,MonocytesVLA-6,α6Integrin120/25

CD50LeukocytesICAM-3124

CD51PlateletsαVIntegrin125/25

CD51/61Platelets,Osteoclasts,Endothelialcellscomplex

CD52LeukocytesCAMPATH-121-28

CD53Leukocytes32-40

CD54Endothelialcells,VariousactivatedcellsICAM-190

CD55BroadDecayAcceleratingFactor75

CD56NKcellsN-CAM220/135

CD57NKcells,TcellsubsetHNK-1110

CD58BroadLFA-365-70

CD59Broad

Protectin,HomologousRestrictionFactor18-20

CD60aTcellsubset,plateletsGD3

CHO

CD60bTcellsubset,activatedBcells9-0-sialylGD3

CHO

CD60cTcellsubset7-0-sialylGD3

CHO

CD61Platelets,Megakaryocytesβ3Integrin,GPIIIa110

CD62EEndothelialcellsE-Selectin,ELAM-1140

CD62LLymphocytes,Monocytes,NKcellsL-Selectin,LECAM-1150

CD62PActivatedPlatelets,EndothelialcellsP-Selectin,LECAM-375-80

CD63ActivatedPlatelets,Monocytes53

CD64MonocytesFcRI75

CD65Neutrophils

CD65sNeutrophils,Monocytes

CD66aNeutrophilsBiliaryGlycoprotein160-180

CD66bGranulocytesCGM695-100

CD66cNeutrophils,ColoncarcinomaNCA90

CD66dNeutrophilsCGM130

CD66eColonepithelialCEA180-200

CD66fPregnancySpecificGlycoprotein

CD67(Re-assignedtoCD66b)(重復(fù)CD66b)CD68Monocytes,Macrophages110

CD69ActivatedTandBcells,NKcellsActivationInducerMolecule34/28

CD70ActivatedTandBcells,Reed-Sternbergcells75,95,170

CD71ProliferatingcellsTransferrinReceptor95

CD72Bcells43/39

CD73B&TcellsubsetECTO-5'Nucleotidase69

CD74Bcells,MonocytesInvariantChain41,35,33

CD75Bcellsubset,EpithelialLactosaminesCHO

CD75sBcellsubsetα-2,6-sialylatedLactosaminesCHO

CD77ActivatedBcells,Endothelialcells

CD79aBcellsMB-133,40

CD79bBcellsB2933,40

CD80ActivatedBcellsB7-160

CD81Bcells,Tcells,NeutrophilsTAPA-122

CD82Leukocytes,Platelets50-53

CD83Dendriticcells,ActivatedlymphocytesHB1543

CD84Monocytes,Platelets,Bcells73

CD85Dendriticcells,Monocytes,Bcellsseenote1innotessection110

CD86Monocytes,ActivatedBcellsB7-280

CD87Granulocytes,Monocytes,ActivatedTcellsUPAReceptor50-65

CD88GranulocytesC5aReceptor42

CD89Neutrophils,MonocytesFcαReceptor55-70

CD90Progenitorcellsubset,ThymicStromalcellsTHY-118

CD91Monocytesα2MacroglobulinReceptor600

CD92Neutrophils,Monocytes,Platelets,Endothelialcells70

CD93Neutrophils,Monocytes,Endothelialcells120

CD94NKcells,Tcellsubset30

CD95ApoptoticcellsFAS42

CD96ActivatedTcellsTactile160

CD97ActivatedTcellsCD55Ligand74,80,89

CD98Monocytes,Tcells,Bcells4F280,40

CD99Lymphocytes,Thymocytes32

CD99RTcells,NKcells,Myeloidcells32

CD100Broad150

CD101Granulocytes,Monocytes,ActivatedTcells140

CD102Lymphocytes,MonocytesICAM-260

CD103IntraEpithelialLymphocytesHML-1,αEIntegrin150,25

CD104Epithelial,Schwanncellsβ4Integrin220

CD105EndothelialcellsEndoglin95

CD106ActivatedEndothelialcellsVCAM-1100-110

CD107aActivatedPlateletsLAMP-1110

CD107bActivatedPlateletsLAMP-2120

CD108ActivatedsplenicTcells80

CD109ActivatedTcells,Platelets,EndothelialcellsPlateletActivationFactor170/150

CD110Stemcellsubset,Megakaryocytes,Platelets(v.weak)ThrombopoietinReceptor,Mpl82-84

CD111Stemcellsubset,Macrophages,NeutrophilsPRR/Nectin-164-72

CD112Monocytes,Neutrophils,StemcellsubsetPRR2/Nectin-264-72

CD113Epithelialcells,PlacentaPRR3,Nectin-383

CD114Granulocytes,MonocytesG-CSFReceptor95,139

CD115Monocytes,MacrophagesM-CSFReceptor150

CD116Monocytes,Neutrophils,EosinophilsGM-CSFReceptorαChain60

CD117ProgenitorcellsSCF-Receptor,c-kit145

CD118EpithelialcellsLIFReceptor190

CD119Monocytes,Bcells,EpithelialcellsIFNγReceptor90

CD120aMonocytes,GranulocytesTNFReceptor,Type155

CD120bMonocytes,Granulocytes,TNFReceptor,Type275

Activatedlymphocytes

CD121aTcells,Fibroblasts,EndothelialcellsIL-1Receptor,Type180

CD121bBcells,Monocytes,MacrophagesIL-1Receptor,Type268

CD122Tcellsubset,NKcellsIL-2ReceptorβChain75

CD123Progenitorcells,Granulocytes,Monocytes,Megakaryocytes,IL-3ReceptorαChain70

CD124Bcells,Tcells,ProgenitorcellsIL-4/IL-13Receptor140

CD125Eosinophils,BasophilsIL-5ReceptorαChain60

CD126Plasmacells,ActivatedBcellsIL-6ReceptorαChain80

CD127EarlyBcells,Tcells,Progenitorcells,Monocytes,IL-7ReceptorαChain65-75CD129Notassigned

CD130Plasmacells,ActivatedBcells

gp130ReceptorSubunitforIL-6,IL-11,LIF,OSM,LNTF,CT-1

130CD131MyeloidcellsCommonβChainforIL-3,IL-5,GM-CSFReceptor

120

CD132Broad

CommonγChainforIL-2,IL-4,IL-7,IL-9,IL-15Receptors

64

CD133StemcellsubsetAC-133120

CD134ActivatedTcellsubsetOX4048-50

CD135ProgenitorcellsubsetFlt3/FIk2130-150

CD136EpithelialcellsMacrophageStimulatingProteinReceptor180

CD137Tcellsubset4-1BB30

CD138Plasmacells,EpithelialcellsSYNDECAN-120

CD139GerminalcenterBcells209,228

CD140a(Undetectableonmostnormalcells)PDGFReceptorα180

CD140bEndothelialcellsubset,StromalcellsPDGFReceptorβ180

CD141EndothelialcellsThrombomodulin100

CD142ActivatedMonocytesandEndothelialcellsTissueFactor45

CD143EndothelialcellsubsetAngiotensinConvertingEnzyme170

CD144EndothelialcellsVE-CADHERIN135

CDw145Endothelialcells,Somestromalcells25,90,110

CD146Endothelialcells,ActivatedTcellsMUC18/S-endo118

CD147Endothelialcells,Monocytes,Tcellsubset,Platelets,Erythrocytes,

Neurothelin/Basigin50-60

CD148HematopoieticcellsHPTP-ETA/DEP-1

CD150Tcellsubset,Bcellsubset,ThymocytesSLAM70

CD151Platelets,EndothelialcellsPETA-327

CD152ActivatedTcellsCTLA-444

CD153ActivatedTcellsCD30Ligand40

CD154ActivatedTcells,Mastcells,BasophilsCD40Ligand33

CD155Monocytes,Macrophages,ThymocytesPoliovirusReceptor80-90

CD156aMonocytes,Macrophages,GranulocytesADAM860

CD156bBroadTACE/ADAM1785

CD156cBroadADAM-1098

CD157Monocytes,Neutrophils,EndothelialcellsBST-142-45

CD158Tcellsubset,NKcellsubsetseenote2innotessection

CD158aNKcells,Tcellsubsetp58.1,P50.150,58

CD158bNKcells,Tcellsubsetp58.2,p50-250,58

CD159aNKcellsNKG2a43

CD159cNKcellsNKG2C40

CD160Tcellsubset,NKcellsubsetBy5526

CD161NKcells,TcellsubsetNKR-P160CD162Tcells,Monocytes,Granulocytes,BcellsubsetPSGL-1110

CD162RNKcellsubsetPEN5CHO

CD163MonocytesKiM4130

CD164Tcells,Monocytes,Granulocytes,Bcellsubset,Progenitorcells

MGC-2480

CD165Thymocytes,ThymicepithelialcellsAD2/gp3737

CD166ActivatedLymphocytes,Endothelialcells,FibroblastsALCAM,CD6Ligand100

CD167aEpithelialcells,Myoblasts

DiscoidinDomainReceptor,DDR1120

CD168Thymocytesubset,Tcellsubset,MonocytesRHAMM84-88

CD169MacrophagesubsetSialoadhesin185

CD170Macrophagesubset,NeutrophilsSiglec-5140

CD171Monocytes,Tcellsubset,BcellsL1200

CD172aMonocytes,Tcellsubset,StemcellsSIRPα110

CD172bMonocytes,DendriticcellsSIRPβ150

CD172gTcells,ActivatedNKcellsSIRPγ,SIRPβ245-50

CD173Redcells,Stemcellsubset,PlateletsBloodgroupHtype2CHO

CD174Stemcellsubset,EpithelialcellsLewisYCHO

CD175StemcellsubsetTNCHO

CD175sErythroblastsSialyl-TnCHO

CD176StemcellsubsetThomson-FriedrenreichantigenCHO

CD177NeutrophilsubsetNB156-62

CD178ActivatedTcellsFasligand38-42

CD179aPro-Bcells,Pre-BcellsVprebeta16

CD179bPro-Bcells,Pre-BcellsLambda522

CD180Bcellsubset,Monocytes,DendriticcellsRp105/Bgp9595-105

CD181Neutrophils,TcellsubsetCXCR139

CD182Monocytes,Granulocytes,TcellsubsetCXCR240

CD183ActivatedTcells,ActivatedNKcellsCXCR340

CD184Tcellsubset,Bcells,Monocytes,Dendriticcells,Endothelialcells,

CXCR4

45

CD185Bcells,TcellsubsetCXCR545

CD186TcellsubsetCXCR6,BONZO40

CD191Tcells,Monocytes,StemcellsubsetCCR139

CD192Monocytes,Tcellsubset,Bcells,Basophils,Endothelialcells，

CCR240

CD193Eosinophils,Basophils,Tcellsubset,Dendriticcellsubset，CCR345

CD194Tcells,Bascphils,Platelets,Monocytes(low)CCR441

CD195Monocytes,TcellsubsetCCR545

CD196Tcellsubset,Bcells,DendriticcellsubsetCCR645

CD197TcellsubsetCCR745

CDw198Tcellsubset,MonocytesCCR850

CDw199TcellsubsetCCR950

CD200Thymocytes,Bcells,Endothelium,ActivatedTcellsOX-245-50

CD201EndothelialcellsubsetEndothelialcellProteinCReceptor(EPCR)50

CD202bEndothelialcells,StemcellsTie/Tek150

CD203cBasophils,MegakaryocytesNPP3130-150

CD204MacrophagesMacrophageScavengerReceptor220

CD205Dendriticcells,ThymicepitheliumDEC-205205

CD206Dendriticcellsubset,Macrophages,MonocytesMacrophageMannoseReceptor180

CD207ImmaturelangerhanscellsLangerin40

CD208InterdigitatingdendriticcellsDC-LAMP70-90

CD209DendriticcellsubsetDC-SIGN44

CDw210Tcells,Bcells,NKcells,Monocytes,MacrophagesIL-10R90-110

CD212ActivatedTcells,ActivatedNKcellsIL-12Rβ1100

CD213a1Bcells,Monocytes,Fibroblasts,EndothelialcellsIL-13Rα165

CD213a2Bcells,MonocytesIL-13Rα265

CD217BroadIL-17R120

CD218aLymphocytes,Neutrophils,DendriticcellsubsetIL-18Rα70

CD218bLymphocytes,Neutrophils,DendriticcellsubsetIL-18Rβ70

CD220Broad

InsulinReceptor140+70

CD221Broad

IGF-1Receptor140+70

CD222Broad

IGF-2Receptor/Mannose-6-phosphateReceptor250

CD223ActivatedTcells,ActivatedNKcellsLAG-370

CD224Leukocytes,StemcellsGammaGlutamylTransferase(GGT)27,68

CD225BroadLeu-1317

CD226Tcells,NKcells,Monocytes,PlateletsDNAM-165

CD227Stemcellsubset,EpithelialcellsMUC-1300

CD228Stemcells,MelanomacellsMelanotransferrin80-95

CD229Tcells,BcellsLy-995,110

CD230BroadPrionProtein35

CD231Tcellleukemia,NeuroblastomaTALLA-130-45

CD232BroadVESPR(PlexinC1)200

CD233RedcellsBand390

CD234RedcellsDuffy35-45

CD235aRedcellsGlycophorinA36

CD235bRedcellsGlycophorinB20

CD236Stemcellsubset,RedcellsGlycophorinC/D32/23

CD236RStemcellsubset,RedcellsGlycorphorinC32

CD238Stemcellsubset,RedcellsKell93

CD239Stemcellsubset,RedcellsB-CAM,Lutheran78-85

CD240CE

RedcellsRhesus30CE30-32

CD240D

RedcellsRhesus30D30-32

CD241RedcellsRhesus50Glycoprotein50

CD242RedcellsICAM-442

CD243StemcellsMDR-1180

CD244NKcells,Tcellsubset2B470

CD245Tcellsubsetp220/240220-240

CD246AnaplasticTcellleukemiaAnaplasticLymphomaKinase80

CD247Tcells,NKcellsTCRzetachain16

CD248StromalFibroblasts,TumorendotheliumEndosialin175

CD249Endothelialcells,EpithelialcellsAminopeptidaseA160

CD250ReservedforTNF

CD251Reservedforlymphotoxin

CD252Dendriticcells,Endothelialcells,ActivatedBcellsOX40Ligand34

CD253ActivatedTcells,ActivatedBcells,ActivatedmonocytesTRAIL33-34

CD254ActivatedTcells,Stromalcells,OsteoblastsTRANCE,RANKL35

CD255ReservedforTWEAK

CD256MyeloidcellsAPRIL16

CD257MyeloidcellsBlyS,BAFF45

CD258ActivatedTcells,ImmaturedendriticcellsLIGHT28

CD259ReservedforNGF

CD260Reservedforlymphotoxinbetareceptor

CD261Leukocytes(veryweak),TumorcellsTRAIL-R1,APO257

CD262BroadTRAIL-R2,DR560CD263Broad(weak)TRAIL-R3,DcR165

CD264BroadTRAIL-R4,DcR235

CD265Broad,Osteoclasts,DendriticcellsRANK,TRANCE-R97

CD266HUVECTWEAK-R14

CD267Bcells(weak),ActivatedTcellsTACI32

CD268Bcells,Tcells(weak)BAFF-R25

CD269BcellsBCMA27

CD270ReservedforLIGHTR

CD271Neurons,Stromalcells,FolliculardendriticcellsNGFR75

CD272Th1cellsBTLA

CD273Dendriticcells,ActivatedTcells,ActivatedmonocytesB7-DC,PD-L225

CD274Dendriticcells,ActivatedTcells,ActivatedmonocytesB7-H1,PD-L140

CD275Dendriticcells,Bcells(weak),Tcells(weak),Activatedmonocytes，ICOSL60

CD276Dendriticcellsubset,ActivatedmonocytesB7-H3(long)40-45

CD277Tcells,Bcells,NKcells,Monocytes,Dendriticcells,Stemcell，BT3.1,BTF556

CD278ActivatedTcellsICOS,AILIM56

CD279ActivatedTcells,ActivatedBcellsPD155

CD280Myeloidprogenitors,Fibroblasts,Endothelialcellsubset,Macrophagesubset，

Endo180,TEM22180CD281Monocytes,NeutrophilsTLR1,TIL90

CD282Monocytes,NeutrophilsTLR2,TIL485

CD283Fibroblasts,DendriticcellsTLR3100

CD284Monocytes(weak)TLR485

CD285ReservedforTLR5

CD286Monocytes,Dendriticcells,EndothelialcellsTLR692

CD287ReservedforTLR7

CD288Peripheralbloodleukocytes,Monocytes,DendriticcellsTLR8120

CD289Dendriticcellsubset,ActivatedBcellsTLR9115-120

CD290Blymphocytes,DendriticcellsTLR1095

CD291ReservedforTLR11

CD292BoneprogenitorcellsBMPR1A50-58

CDw293BoneprogenitorcellsBMPR1B50-58

CD294Th2cells,Eosinophils,BasophilsCRTH2,GPR4455-70

CD295Broad,Monocytes(weak)LEPR,OBR130-150

CD296Epithelialcells,Muscle,Tcellsubset,MyeloidcellsubsetART137

CD297Redcells,Erythroblasts,ActivatedmonocytesART4,DombrockBloodGroup38

CD298BroadNa,KATPaseβ3Subunit52

CD299EndothelialcellsubsetDC-SIGNR,L-SIGN45

CD300aDendriticcells,Monocytes,LymphocytesubsetsCMRFH60

CD300cDendriticcells,Monocytes,LymphocytesubsetsCMRF35A

CD300eMonocytesCMRF35L1

CD301ImmaturedendriticcellsMGL,CLECSF1438

CD302Granulocytes,Monocy