FABPs-ligand-6-MF6-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEFABPsligand6Cat.No.:HY-145990Synonyms:MF6分?式:C??H??FN?O?分?量:458.52作?靶點(diǎn):FABP作?通路:MetabolicEnzyme/Protease儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(545.23mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.1809mL10.9046mL21.8093mL5mM0.4362mL2.1809mL4.3619mL10mM0.2181mL1.0905mL2.1809mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.54mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性FABPsligand6(MF6)?種FABP5和FABP7抑制劑，KD值分別為874nM和20nM。FABPsligand6可?于多發(fā)性硬化癥的研究。IC50&TargetKD:20nM(FABP7),874nM(FABP5)[1]體外研究FABPsligand6(MF6)rescuesmitochondrialfunctionbyblockingvoltagedependentanionchannel(VDAC)-1-dependentmitochondrialmacroporeformationinducedbypsychosineinKG-1Ccells,aFABP5-mediatedinjury[1].體內(nèi)研究MF6(1mg/kg;i.g.;dailyfor4weeks)improvestheseverityofEAE(experimentalautoimmuneencephalomyelitis)andattenuatesoxidativelevelsandtheinflammatoryresponse[1].AnimalModel:8-10-week-oldfemaleC57BMF/6JmicewithMOG35-55-administeredexperimentalautoimmuneencephalomyelitis(EAE)mousemodel[1]Dosage:1mg/kgAdministration:Intragastricadministration,dailyfor4weeksResult:AttenuatedEAEsymptoms,decreasedoxidativestress,inhibitedastrocyteactivationandprotectedoligodendrocytes.REFERENCES[1].ChengA,etal.Anovelfattyacid-bindingprotein5and7inhibitoramelioratesoligodendrocyteinjuryinmultiplesclerosismousemodels.EBioMedicine.2021Oct;72:103582.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.T