Antibacterial-agent-89-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAntibacterialagent89Cat.No.:HY-146722CASNo.:2589639-87-0分?式:C??H??Cl?F?NO?S分?量:516.27作?靶點(diǎn):Bacterial;DNA/RNASynthesis作?通路:Anti-infection;CellCycle/DNADamage儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Antibacterialagent89?種強(qiáng)效抗劑。Antibacterialagent89顯?出抗梭活性。Antibacterialagent89抑制細(xì)胞毒素的釋放和β'CH-σ相互作?。Antibacterialagent89?擾細(xì)轉(zhuǎn)錄的過程[1]。體外研究Antibacterialagent89(compound8e)showsantimicrobialactivityforSPNE(Streptococcuspneumoniae(S.pneumoniae))ATCC49619,Streptococcusaureus(S.aureus)ATCC25923,S.aureusATCC29213withMICof2,4,4μg/mL,respectively[1].Antibacterialagent89(48h)showsanti-clostridialactivityagainstclinicallyimportantGram-positivepathogenswithMICof0-8μg/mL[1].Antibacterialagent89(48h)inhibitsthereleaseofcytotoxinsToxinA(TcdA)andToxinB(TcdB)inadose-dependentmannerinC.difficileATCC9689,ribotype002,ribotype027[1].Antibacterialagent89inhibitstheβ’CH-σinteractionwithanIC50of2.12μM[1].Antibacterialagent89(1,2,4μg/mL;B.subtilis)altersthelocalizationofbacterialtranscriptioncomplexes[1].Antibacterialagent89(0.5,0.25μg/mL)reducestheexpressionofDNA,RNA,proteinlevelsinS.aureusATCC29213cells[1].WesternBlotAnalysis[1]CellLine:S.aureusATCC29213cellsConcentration:0.5,0.25μg/mLIncubationTime:1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEResult:ReducedthetotallevelsofproteinobservedinS.aureusATCC29213cells.REFERENCES[1].YeJ,etal.BenzylandbenzoylbenzoicacidinhibitorsofbacterialRNApolymerase-sigmafactorinteraction.EurJMedChem.2020Dec15;208:112671.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37