Umirolimus-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrariesUmirolimusCat.No.:HY-122402CASNo.:851536-75-9分?式:C??H??NO??分?量:986.28作?靶點:Others作?通路:Others儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗DMSO:200mg/mL(202.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.0139mL5.0696mL10.1391mL5mM0.2028mL1.0139mL2.0278mL10mM0.1014mL0.5070mL1.0139mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存?式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：為保證實驗結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實驗的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶1.請依序添加每種溶劑：10%DMSO90%(20%SBE-β-CDinsaline)Solubility:5mg/mL(5.07mM);Suspendedsolution;Needultrasonic此?案可獲得5mg/mL(5.07mM)的均勻懸濁液，懸濁液可?于?服和腹腔注射。以1mL?作液為例，取100μL50.0mg/mL的澄DMSO儲備液加到900μL20%的SBE-β-CD?理鹽??溶2.液中，混合均勻。請依序添加每種溶劑：10%DMSO90%cornoilSolubility:≥5mg/mL(5.07mM);Clearsolution1/2此?案可獲得≥5mg/mL(5.07mM，飽和度未知)的澄溶液，此?案不適?于實驗周期在半個?以上的實驗。以1mL?作液為例，取100μL50.0mg/mL的澄DMSO儲備液加到900μL??油中，混合均勻。BIOLOGICALACTIVITY?物活性Umirolimus?種?環(huán)三烯內(nèi)酯Rapamycin的衍?物，?種強?的免疫抑制劑和抗炎劑。Umirolimus具有?度的親脂性，可?做藥物洗脫?架。體外研究Umirolimusisamacrocyclictrienelactone,developedwithpharmacologicalpropertiesspecificallytailoredforlocalizeddrugdelivery.Umirolimuscanbeuseddrug-elutingstent(DES)applications.Owingtoitsenhancedlipophilicity,itisstronglyattractedtobindingsiteswithinthevesselwallandsmall,tortuousvessels,andcontributingtocellularabsorptionandsustaineddistributioninthevesselwallsurroundingthestent[1].UmirolimuspreventsprogressionofthecellcycleinG1phasebyinhibitingIL-2/mTOR-mediatedP70-KDS6proteinkinaseactivation.UmirolimusinhibitsT-cellgrowth,aswellassmoothmusclecellgrowth[1].體內(nèi)研究Theeliminationhalf-lifeofUmirolimusisapproximately25hinwholeblood[1].REFERENCES[1].EberhardGrube,etal.BioMatrixBiolimusA9-elutingcoronarystent:anext-generationdrug-elutingstentforcoronaryarterydisease.ExpertRevMedDevices.2006Nov;3(6):731-41.McePdfHeightMedChemExpress(MCE)只為有資質(zhì)的科研機構(gòu)、醫(yī)藥企業(yè)基于科學(xué)