贛州市人民醫(yī)院泌尿外科鄧小林：維生素D與男性不育癥的相關(guān)研究課件

維生素D與男性不育癥的相關(guān)研究贛州市人民醫(yī)院泌尿外科鄧小林

一、概述：男性不育一、VD來源及代謝EurJEndocrinol.2012May;166(5):765-78.VitaminDandfertility:asystematicreview.NatRevEndocrinol.2014Mar;10(3):175-86.VitaminDandmalereproductionVitaminDAndrogenstatusSemenTesticulopathyPositiveassociationofandrogenswith

25(OH)DlevelsConcordantseasonalvariationof

testosteroneand25(OH)DLowvitaminDstatusisassociatedwith

secondaryandcompensated

hypogonadismVitaminDtreatmentmightincrease

testosteronelevelsPositiveassociationofvitaminD

statuswithsemenquality(motility,morphology)1,25(OH)2D3increasessperm

motilityandinducesacrosomereaction

invivoAssociatedwithlow

CYP2R1expressionandlow25(OH)DlevelsTesticulopathicmenshow

osteoporosisandosteopenia

includingalteredbonemarkerlevels

andbonemineraldensitydespite

normaltestosteronelevels

三、VD與男性生殖EurJEndocrinol.2012May;166(5):765-78.VitaminDandfertility:asystematicreview.（一）VDR及代謝酶的表達(dá)

VDR在精子頭部、頸部高表達(dá)VDR精子中段、尾部部無表達(dá)JAnat.2008Nov;213(5):555-64.Humanspermanatomy:ultrastructurallocalizationof1alpha,25-dihydroxyvitaminDreceptoranditspossibleroleinthehumanmalegamete（一）VDR及代謝酶的表達(dá)

2010May;25(5),HumanReproduction:VitaminDreceptorandvitaminDmetabolizingenzymesareexpressedinthehumanmalereproductivetract睪丸前列腺（一）VDR及代謝酶的表達(dá)差異正常組對照組CYP24A1的表達(dá)2010May;25(5),HumanReproduction:VitaminDreceptorandvitaminDmetabolizingenzymesareexpressedinthehumanmalereproductivetract（二）調(diào)節(jié)精子蛋白磷酸化酪氨酸磷酸化蘇氨酸磷酸化JAnat.2008Nov;213(5):555-64.Humanspermanatomy:ultrastructurallocalizationof1alpha,25-dihydroxyvitaminDreceptoranditspossibleroleinthehumanmalegamete（四）VD與精液參數(shù)VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317（五）VD調(diào)節(jié)精子Ca2+濃度VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317（五）VD調(diào)節(jié)精子Ca2+濃度VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317調(diào)節(jié)網(wǎng)絡(luò)（五）VD調(diào)節(jié)精子Ca2+濃度（六）調(diào)節(jié)頂體反應(yīng)VitaminDispositivelyassociatedwithspermmotilityandincreasesintracellularcalciuminhumanspermatozoa.Humanreproduction,2011.26(6):p.1307-1317（七）與睪酮的季節(jié)性

25(OH)VD睪酮游離睪酮指數(shù)ClinEndocrinol(Oxf).2010Aug;73(2):243-8.AssociationofvitaminDstatuswithserumandrogenlevelsinmen（八）流行病學(xué)FertilSteril.2011Mar1;95(3):1000-4.AreserumlevelsofvitaminDassociate