1-Cyclohexyl-3-dodecyl-urea-CDU-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE1-Cyclohexyl-3-dodecyl ureaCat. No.: HY-135795CAS No.: 402939-18-8Synonyms: CDU; N-Cyclohexyl-N-dodecyl urea; NCND分式: CHNO分量: 310.52作靶點(diǎn): Others作通路: Others儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)

2、據(jù)體外實(shí)驗(yàn) Ethanol : 16.67 mg/mL (53.68 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.2204 mL 16.1020 mL 32.2040 mL5 mM 0.6441 mL 3.2204 mL 6.4408 mL10 mM 0.3220 mL 1.6102 mL 3.2204 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為

3、保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% EtOH 90% corn oilSolubility: 1.67 mg/mL (5.38 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND)種具

4、有度選擇性的可溶性環(huán)氧化物解酶 (sEH) 抑制劑。1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) 可提管緊張素 II (Ang II) 壓中的環(huán)氧碳三烯酸 (EETs) 平并降低壓。IC50 & Target IC50: soluble epoxide hydrolase (sEH) 1體內(nèi)研究 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) ( intraperitoneal injection; 3mg/day

5、;4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oilvehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals 1.Animal Model: Male Sprague-Dawley rats 1Dosage: 3mg/dayAdministration: Intraperitoneal injection; 4 daysRes

6、ult: Had antihypertensive properties.REFERENCES1. Imig JD,et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.Hypertension. 2002Feb;39(2 Pt 2):690-4.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820