腫瘤能量代謝重排與轉移關系

1、腫瘤能量代謝重排（reprograming）與轉移2。腫瘤細胞即使在供氧充足的情況下，葡萄糖依舊向乳酸轉換，這種代(aerobicglycolysis“Warburg(Warburgeffect)協(xié)調(diào)，產(chǎn)生代謝共生 (metabolism of symbiosis)。腫瘤組織存在著異常復雜的微環(huán)境重編程 (metabolic reprogramming)。腫瘤的能量代謝重編程是指腫瘤細胞中 ATP 的主要生成方式由葡萄糖的有氧氧化偶聯(lián)18F-脫氧葡萄糖-PET/CT3。能量代謝是有機體在物質(zhì)代謝過程中能量的產(chǎn)先鋒理論-Warburg 效應 4。雖然糖酵解產(chǎn)能效率低，但對于快速增殖的腫瘤細胞而言

2、這卻ATP，還能為新細胞的構筑提供多種生物大分子，從1.ATP6。reprogramming8。Venkatanarayanp63p73N37IAPPp539。他們I/IIp53快速退化，這為日后靶向 p53 缺失的腫瘤的治療提供了參考。Jiang L 等人發(fā)現(xiàn), TGF1EMT Snail1（FASNTGF1EMT10（PGC-1）入性乳腺癌的臨床分析發(fā)現(xiàn)，PGC-1PGC-111。此外，被認為來源于間充質(zhì)干細12-14。1B1617。在以雙室模型代謝方式為主的腫瘤組織中，基質(zhì)細胞發(fā)生過4其他氨基酸等支持腫瘤細胞的生長。而癌細胞攝取代謝產(chǎn)物的轉運體單羧酸轉運蛋白 1 表轉運蛋白 4 進行自噬

3、和糖酵解為主的分解代謝，另一部分腫瘤細胞主要表達單羧酸轉運蛋1ATPmicroRNA WaburgWarbugWarburg過調(diào)整能量代謝以適應其生物合成的需要 20（oxidativephosphorylation，OXPHOS）作為生物能量來源時，腫瘤細胞卻更多地依賴于糖酵解， 這種轉變稱為“ Warburg 效應”。能量代謝重組（reprogrammingofenergy 些基因的調(diào)控， 也依賴于特定的物質(zhì)（ 如谷氨酰胺等 。此 外， 缺氧誘導因子（hypoxia-induciblefactor，HIF）21。腫瘤細胞還可通過其他途徑，如逆向“ Warburg 效應”和截斷的三羧酸循環(huán)（

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