Beta-d-N4-hydroxycytidine-NHC-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBeta-d-N4-hydroxycytidineCat. No.: HY-125033CAS No.: 3258-02-4Synonyms: NHC分式: CHNO分量: 259.22作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 years* 該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。溶解性數(shù)據(jù)體外實驗 DMSO : 250 mg/mL (964.43 mM; Need ultrasonic

2、)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.8577 mL 19.2886 mL 38.5773 mL5 mM 0.7715 mL 3.8577 mL 7.7155 mL10 mM 0.3858 mL 1.9289 mL 3.8577 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液；該產(chǎn)品在溶液狀態(tài)不穩(wěn)定，建議您現(xiàn)現(xiàn)配，即刻使。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥蔚膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲備液可以根據(jù)儲存條件，適當(dāng)保

3、存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (8.02 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (8.02 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑

4、師www.MedChemESolubility: 2.08 mg/mL (8.02 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Beta-d-N4-hydroxycytidine種常有效的抗委內(nèi)瑞拉馬腦炎病毒劑 (anti-VEEV) ，EC50， EC90 和 EC99分別為 0.426，1.036 和 2.5 M 1。REFERENCES1. Urakova N, et al. -d-N-Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the ViralGenome. J Virol. 2018 Jan 17;92(3). pii: e01965-17.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;F