Olopatadine-hydrochloride-ALO4943A-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEOlopatadine hydrochlorideCat. No.: HY-B0426ACAS No.: 140462-76-6Synonyms: ALO4943A; KW4679分式: CHClNO分量: 373.87作靶點(diǎn): Histamine Receptor作通路: GPCR/G Protein; Immunology/Inflammation; NeuronalSignaling儲(chǔ)存式: Powder -20C 3 years4C 2 yea

2、rsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 50 mg/mL (133.74 mM; Need ultrasonic)H2O : 6.67 mg/mL (17.84 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.6747 mL 13.3736 mL 26.7473 mL5 mM 0.5349 mL 2.6747 mL 5.3495 mL10 mM 0.2675 mL 1.3374 mL 2.6747 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶

3、解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍?，配制前?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (6.69 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD

4、in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (6.69 mM); Clear solution3. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (6.69 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Olopatadine 鹽酸鹽(ALO4943A)組胺受體阻斷劑，可作于過敏性結(jié)膜炎。REFERENCES1. Tamura, T., et al., Effect of olo

5、patadine and other histamine H1 receptor antagonists on the skin inflammation induced by repeatedtopical application of oxazolone in mice. Pharmacology, 2005. 75(1): p. 45-52.2. Ohmori, K., et al., Pharmacological, pharmacokinetic and clinical properties of olopatadine hydrochloride, a new antialler

6、gic drug. Jpn JPharmacol, 2002. 88(4): p. 379-97.3. Yanni, J.M., et al., The in vitro and in vivo ocular pharmacology of olopatadine (AL-4943A), an effective anti-allergic/antihistaminic agent.J Ocul Pharmacol Ther, 1996. 12(4): p. 389-400.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-8