SKF-86002 - p38 MAPK 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemESKF-86002Cat. No.: HY-12511CAS No.: 72873-74-6分式: CHFNS分量: 297.35作靶點(diǎn): p38 MAPK作通路: MAPK/ERK Pathway儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 33.33 mg/mL (112.09 mM; Need ultrasonic)Ma

2、ss Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.3630 mL 16.8152 mL 33.6304 mL5 mM 0.6726 mL 3.3630 mL 6.7261 mL10 mM 0.3363 mL 1.6815 mL 3.3630 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄清的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的

3、百分 指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.41 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (8.41 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 SKF-86002是p38MAPK抑制劑，IC50值為0.

4、5-1uM。REFERENCES1. Griswold DE, et al. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediatedmetabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.2. Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and

5、 -independent intracellular signal transduction pathways leading toapoptosis in human neutrophils. J Biol Chem. 1998 Apr 3;273(14):8389-97.3. Nick JA, et al. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.J Clin Invest. 1997 Mar 1;99(5):975-86.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02