R112 - Syk 抑制劑 - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemER112Cat. No.: HY-16420CAS No.: 575474-82-7分式: CHFNO分量: 312.3作靶點(diǎn): Syk作通路: Protein Tyrosine Kinase/RTK儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 41 mg/mL (131.28 mM)* means soluble, but

2、saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.2020 mL 16.0102 mL 32.0205 mL5 mM 0.6404 mL 3.2020 mL 6.4041 mL10 mM 0.3202 mL 1.6010 mL 3.2020 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 R112種ATP競(jìng)爭(zhēng)性的Syk激酶抑制劑, Ki值為6 nM. R112抑制Syk激酶活性, IC50值為226 nM。REF

3、ERENCES1. Rossi AB, et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol. 2006Sep;118(3):749-755.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE2. Meltzer EO, et al. An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. JAllergy Clin Immunol. 2005 Apr;115(4):791-796.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax:/p>