PROTAC-BET-degrader-2 - PROTAC - 生命科學(xué)試劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEPROTAC BET degrader-2Cat. No.: HY-114228CAS No.: 2093388-33-9分式: CHNO分量: 770.84作靶點(diǎn): Epigenetic Reader Domain; PROTAC作通路: Epigenetics; PROTAC儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 5

2、0 mg/mL (64.86 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (3.24 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 2.5 mg/mL (3.24 mM); Clear solution1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 PROTAC BET degrader-2種強(qiáng)效的

3、 溴域及末端外 (BET) 蛋的降解劑，在 RS4;11 細(xì)胞中測得其對細(xì)胞長的 IC50 值為 9.6 nM，并能實(shí)現(xiàn)腫瘤消退。IC50 & Target IC50: 9.6 nM (BET in the RS4;11 leukemia cell line) 1.體外研究 PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal(BET) proteins with an IC50 value of 9.6 nM in cell growth inhibi

4、tion in the RS4;11 cells and capable ofachieving tumor regression 1.REFERENCES1. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar CellularPotencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: