多組分反應和串聯(lián)反應課件

1、第五章 Multi-Component ReactionsMulticomponents reactions (MCRs) are those reactions in which three or more reactants come together in a single reaction vessel to form a new product which contains portions of all the componentsMCRA+B+C.PConvergencyComplexityProductivitySelectivityAtom economyDiversity一

2、、多組分反應的歷史Ivar Karl Ugi (1930-2005), the inventor of the most significant isocyanide based MCRs.二、多組分反應涉及的反應機理1.離子機理異腈參與的多組分反應大多為離子機理。Angew. Chem. Int. Ed. 1998, 37, 22342.自由基機理Angew. Chem. Int. Ed. 2003, 42, 34903.周環(huán)反應機理Tetrahedron Lett. 1998, 29, 58554.混合機理自由基和負離子組合Angew. Chem. Int. Ed. 1998, 37, 1

3、52三、金屬催化的多組分反應四、多組分反應展望Hardly a field in organic chemistry has evolved faster over only a couple of years than MCRs. However, the very large MCR space of 1020 is only explored marginally.Future research in the area of MCRs will include the discovery and design of novel MCRs, combinations of MCRs and

4、 traditional reactions, experimental improvements in solid-and liquid-phase, enantio-and diastereo-selective variations, and more and more applications in drug discovery, material science, bioconjugates, and agrochemical compounds.第六章 串聯(lián)反應新進展串聯(lián)反應（Tandem reaction）串級反應(Cascade reaction)多米諾反應(Domino reaction)連續(xù)反應(Sequential reaction)Tandem reactions, in which multiple reactions are combined into one synthetic operation, have been reported extensively in the synthetic chemistry literature. . Angew. Chem. Int. E