Rotundine-minus-Tetrahydropalmatine-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemERotundineCat. No.: HY-N0096CAS No.: 483-14-7Synonyms: (-)-Tetrahydropalmatine; L-Tetrahydropalmatine分式: CHNO分量: 355.43作靶點(diǎn): 5-HT Receptor; Dopamine Receptor作通路: GPCR/G Protein; Neuronal Signaling儲(chǔ)存式: Powder -20C 3 years4C 2 years

2、In solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/mL (281.35 mM)H2O : 0.05, F(3, 37)=0.348, P0.05, respectively. Locomotor counts are greatly increased in theoxycodone group compare with the saline group. Rotundine at doses of 6.25, 12.5, and 18.75 mg/kgantagonizes hyperactivity induced by

3、 oxycodone F(4, 60)=15.76, P 2.PROTOCOLAnimal Kunming mice, initially weighing 18 to 22 g are used in this study. Four groups of mice are given RotundineAdministration 2 (l-THP) (6.25, 12.5, and 18.75 mg/kg) or saline, respectively, once per day for 7 consecutive days, followedby a 5 d withdrawal pe

4、riod. On d 13, all animals are challenged with saline. On day 1, 7, and 13, after 40-mintreatment with Rotundine or saline, the mice are put into the test boxes and locomotor activity is monitoredfor 60 min 2.MCE has not independently confirmed the accuracy of these methods. They are for reference o

5、nly.REFERENCES1. Wang JB, et al. l-tetrahydropalamatine: a potential new medication for the treatment of cocaine addiction. Future Med Chem. 2012Feb;4(2):177-86.2. Liu YL, et al. Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice. Acta Pharmacol Sin. 2005 May;26(5):533-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021