Bedaquiline-TMC207-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEBedaquilineCat. No.: HY-14881CAS No.: 843663-66-1Synonyms: TMC207; R207910分式: CHBrNO分量: 555.5作靶點(diǎn): Bacterial作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 20 mg/mL (36.00

2、 mM; Need ultrasonic)H2O : 40% PEG300 5% Tween-80 45% salineSolubility: 2 mg/mL (3.60 mM); Suspended solution; Need ultrasonic2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2 mg/mL (3.60 mM); Suspended solution; Need ultrasonic1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE3. 請(qǐng)依序添加每種

3、溶劑： 10% DMSO 90% corn oilSolubility: 2 mg/mL (3.60 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Bedaquiline種芳 喹啉抗素，可抑制分枝桿菌ATP合成酶。IC50 & Target mycobacterial ATP synthase 1體外研究 Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5mg/L 1. Among slowly g

4、rowing mycobacteria (SGM), bedaquiline exhibits the highest activity againstMycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidlygrowing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) andMycobacterium abscessus subsp. massiliens

5、e (M. massiliense) seem more susceptible to bedaquiline thanMycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and 16 mg/L, respectively, for both species.Bedaquiline also shows moderate in vitro activity against NTM species 2. Bedaquiline has an excellent invitro activity against Mycobact

6、erium tuberculosis, including multidrug resistant M tuberculosis 3.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Antimicrob Agents Chemother. 2019 Jul 29. Front Microbiol. 2018 Aug 15;9:1898. Front Cell Infect Microbiol. 2016 Nov 8;6:145. eCollection 2016.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Jang JC,

7、 et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20.2. Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr24;61(5).3. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. Ann Pharmacother. 2014 Jan;48(1):107-15.McePdfHeightCaution: Product has not been fully validated for medical applications.For rese