Diosgenin _STAT 抑制劑 - MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDiosgeninCat. No.: HY-N0177CAS No.: 512-04-9分式: CHO分量: 414.62作靶點(diǎn): STAT作通路: JAK/STAT Signaling; Stem Cell/Wnt儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) Ethanol : 6.67 mg/mL (16.09 mM; Need ult

2、rasonic)DMSO : 40% PEG300 5% Tween-80 45% salineSolubility: 0.67 mg/mL (1.62 mM); Clear solution2. 請依序添加每種溶劑： 10% EtOH 90% (20% SBE-CD in saline)Solubility: 0.67 mg/mL (1.62 mM); Clear solution3. 請依序添加每種溶劑： 10% EtOH 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 0.67 mg/mL

3、(1.62 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Diosgenin，種甾體皂苷，能夠抑制 STAT3 信號通路。Diosgenin是Pdia3/ERp57 的激活劑 4。IC50 & Target STAT3體外研究 In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 M, may represent agood candidate as a steroidal moiety in our bivalent compounds

4、 against AD pathology 1. Diosgenin inhibitsthe constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibitionoccurring at around 100 M 2.體內(nèi)研究 Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenintreatment signi

5、ficantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice 3.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Cell Physiol Biochem. 2016;39(4):1626-37.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin as

6、multifunctional compounds against Alzheimersdisease. Bioorganic & Medicinal Chemistry, 23 (2015) 732473312. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation andchemosensitization of human hepatocellular carcinoma cells. Cancer Lett

7、. 2010 Jun 28;292(2):197-207.3. Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ER in the regulation of PPAR. Toxicol Appl Pharmacol. 2015 Dec1;289(2):286-96.4. Tohda C, et al. Diosgenin is an exogenous activator of 1,25D-MARRS/Pdia3/ERp57 and improves Alzheimers disease pathologies in 5XFADmice. Sci Rep. 2012;2:535.McePdfHeightCaution: Product has not been fully validated for medical applications.For research