Enterovirus-Inhibitors-Modulators-MCE

1、 HYPERLINK https:/www.MedChemE/Targets/Rhinovirus (HRV).html EnterovirusRhinovirus; HRV; HRVs; HEV; HEVsThe genus Enterovirus (EV) belonging to the Picornaviridae family comprises 13 species, of which seven are human viruses. Four ofthe species are: (1) EV-A such as coxsackievirus (CV)-A6, CV-A10, C

2、V-A16 and EV-A71, (2) EV-B such as the CV-B viruses,echoviruses (ECHO) and CV-A9, (3) EV-C such as polioviruses (PV) and CV-A21, (4) EV-D such as EV-D68 and EV-D70. The otherthree species are rhinoviruses RV-A, RV-B and RV-C which comprised over 100 different numbered RVs. Infection with enterovirus

3、escan cause numerous clinical conditions including poliomyelitis, meningitis and encephalitis, hand-foot-and-mouth disease, acuteflaccid paralysis, diarrhea, myocarditis and respiratory illness.Enteroviruses are small, nonenveloped, positive-sense, single-stranded RNA viruses with an icosahedral cap

4、sid. The genome of 7.5kb encodes a single polyprotein that is autoprocessed into structural proteins (VP1, VP2, VP3, and VP4), nonstructural proteins (2A,2B, 2C, 3A, 3B, 3C, and 3D), and several functional processing intermediates. The viral nonstructural proteins, particularly theprotease 3Cpro and

5、 the RNA-dependent RNA polymerase 3Dpol, are attractive targets for antiviral drug development.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Rhinovirus (HRV).html Enterovirus HYPERLINK https:/www.MedChemE/Targets/Rhinovirus (HRV).html HYPERLINK https:/www.MedChemE/Targets/Rhinovirus (HRV).htm

6、l Inhibitors HYPERLINK https:/www.MedChemE/rac-golgicide-a.html (Rac)-Golgicide HYPERLINK https:/www.MedChemE/rac-golgicide-a.html HYPERLINK https:/www.MedChemE/rac-golgicide-a.html A(Rac)-GCA) Cat. No.: HY-100540A HYPERLINK https:/www.MedChemE/al-470.html AL-470Cat. No.: HY-146009(Rac)-Golgicide A

7、(Rac)-GCA) is a racemate ofGolgicide A. Golgicide A (GCA) is a potent, highlyspecific, and reversible inhibitor of thecis-Golgi ADP-ribosylation factor guaninenucleotide exchange factors (ArfGEF)GBF1.AL-470 is a potent antiviral agent with EC50values of 0.27, 0.63, and 0.35 M against HIV-1,HIV-2, an

8、d EV-A71, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/brilliant-black-bn.html Brilliant HYPERLINK https:/www.MedChemE/brilliant-black-bn.html HYPERLINK https:/www.MedChem

9、E/brilliant-black-bn.html Black HYPERLINK https:/www.MedChemE/brilliant-black-bn.html HYPERLINK https:/www.MedChemE/brilliant-black-bn.html BN(E 151) Cat. No.: HY-128382 HYPERLINK https:/www.MedChemE/carbocisteine.html Carbocisteine(S-(Carboxymethyl)-L-cysteine) Cat. No.: HY-D0205ABrilliant black BN

10、 (E151) is an azo dye and afood colorant. Brilliant black BN is a promisingantiviral agent against EV71 infection viainhibiting the interaction between EV71 and itscellular uncoating factor cyclophilin A.Carbocisteine, a mucolytic agent, can be used forthe research of chronic obstructive pulmonarydi

11、sease (COPD).Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 25 mg, 100 mgPurity: 98.0%Clinical Data: LaunchedSize: 10 mM 1 mL, 100 mg HYPERLINK https:/www.MedChemE/cis-resveratrol.html cis-ResveratrolCat. No.: HY-16561A HYPERLINK https:/www.MedChemE/Corydaline.html Corydaline(+

12、)-Corydaline; Corydalin) Cat. No.: HY-N0923cis-Resveratrol exhibits signifcant antiviralactivity. cis-Resveratrol inhibits enteroviruseswith IC s of 12.2 M and 37.6 M for50coxsackievirus B3 (CVB3) and enterovirus 71(EV71), respectively.Corydaline (+)-Corydaline), an isoquinolinealkaloid isolated fro

13、m Corydalis yanhusuo, is anAChE inhibitor with an IC of 226 M. Corydaline50is a -opioid receptor (K of 1.23 M) agonist andiinhibits enterovirus 71 (EV71) replication (IC50of 25.23 M).Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mgPurity: 97.52%Clinical Data: No Development

14、ReportedSize: 10 mM 1 mL, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/dc07090-dihydrochloride.html DC07090 HYPERLINK https:/www.MedChemE/dc07090-dihydrochloride.html HYPERLINK https:/www.MedChemE/dc07090-dihydrochloride.html dihydrochloride HYPERLINK https:/www.MedChemE/dc07090-dihydrochloride.html HY

15、PERLINK https:/www.MedChemE/dma-135-hydrochloride.html DMA-135 HYPERLINK https:/www.MedChemE/dma-135-hydrochloride.html HYPERLINK https:/www.MedChemE/dma-135-hydrochloride.html hydrochlorideCat. No.: HY-123517 Cat. No.: HY-145932DC07090 dihydrochloride is a low toxicity, potent,reversible and compet

16、itive non-peptidyl humanenterovirus 71 3C protease inhibitor with an IC50and a K value for 21.72 M and 23.29 M.iDMA-135 hydrochloride inhibits enterovirus 71(EV71) IRES-dependent translation andreplication. DMA-135 hydrochloride binds toenterovirus 71 (EV71) SLII domain with moderatelyhigh affinity

17、(K =520nM).DPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/beta-d-n4-hydroxycytidine.html EIDD-1931 HYPERLINK https:/www.MedChemE/beta-d-n4-hydroxycytidine.html HYPERLINK https:/www.MedC

18、hemE/ev-a71-in-1.html EV-A71-IN-1(-D-N4-hydroxycytidine; NHC) Cat. No.: HY-125033Cat. No.: HY-145850EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is anovel nucleoside analog and behaves as a potentanti-virus agent. EIDD-1931 effectively inhibitsthe replication activity of venezuelan equineencephalitis

19、virus (VEEV), Chikungunya virus(CHIKV) and hepatitis C virus (HCV).EV-A71-IN-1 is a human enterovirus A71 (EV-A71)capsid protein inhibitor with an EC of 0.27 M50against EV-A71. EV-A71-IN-1 is a capsid binderthat blocks the interaction between the viral VP1and the host receptor hSCARB2.Purity: 99.73%

20、Clinical Data: No Development ReportedSize: 5 mg, 10 mg, 25 mg, 50 mg, 100 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/Fluticasone-propionate.html Fluticasone HYPERLINK https:/www.MedChemE

21、/Fluticasone-propionate.html HYPERLINK https:/www.MedChemE/Fluticasone-propionate.html (propionate) HYPERLINK https:/www.MedChemE/Fluticasone-propionate.html HYPERLINK https:/www.MedChemE/fluticasone-propionate-d3.html Fluticasone HYPERLINK https:/www.MedChemE/fluticasone-propionate-d3.html HYPERLIN

22、K https:/www.MedChemE/fluticasone-propionate-d3.html propionate-d3Cat. No.: HY-B0154 Cat. No.: HY-B0154SFluticasone propionate, a potent topicalanti-inflammatory corticosteroid, is a selectiveglucocorticoid receptor agonist, with an absoluteaffinity (K ) of 0.5 nM. Fluticasone propionateDshows littl

23、e or no activity at other steroidreceptors. Anti-viral activity.Fluticasone propionate-d3 is the deuterium labeledFluticasone propionate. Fluticasone propionate, apotent topical anti-inflammatory corticosteroid,is a selective glucocorticoid receptor agonist,with an absolute affinity (K ) of 0.5 nM.D

24、Purity: 99.97%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg, 50 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/fluticasone-propionate-d5.html Fluticasone HYPERLINK https:/www.MedChemE/fluticasone-propionate-d5.html HYPERLINK https:/www.MedChemE/flu

25、ticasone-propionate-d5.html propionate-d5 HYPERLINK https:/www.MedChemE/fluticasone-propionate-d5.html HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html Ganoderic HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html acid HYPERLINK https:/www.MedCh

26、emE/ganoderic-acid-y.html HYPERLINK https:/www.MedChemE/ganoderic-acid-y.html YCat. No.: HY-B0154S1 Cat. No.: HY-125713Fluticasone propionate-d5 is deuterium labeledFluticasone (propionate). Fluticasone propionate,a potent topical anti-inflammatory corticosteroid,is a selective glucocorticoid recept

27、or agonist,with an absolute affinity (KD) of 0.5 nM.Ganoderic acid Y is a -glucosidase inhibitor withan IC of 170 M for yeast -glucosidase.50Ganoderic acid Y inhibits enterovirus 71 (EV71)replication through blocking EV71 uncoating.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPur

28、ity: 99.07%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/golgicide-a.html Golgicide HYPERLINK https:/www.MedChemE/golgicide-a.html HYPERLINK https:/www.MedChemE/golgicide-a.html A(GCA) Cat. No.: HY-100540 HYPERLINK https:/www.MedChemE/golgicide-a-2.html Golgici

29、de HYPERLINK https:/www.MedChemE/golgicide-a-2.html HYPERLINK https:/www.MedChemE/golgicide-a-2.html A-2(GCA-2) Cat. No.: HY-100540BGolgicide A (GCA) is a potent, highly specific,and reversible inhibitor of the cis-GolgiADP-ribosylation factor guanine nucleotideexchange factors (ArfGEF) GBF1. Golgic

30、ide Adrastically reduced replication of coxsackievirusB3 (CVB3) and other human enterovirus species.Golgicide A-2 (GCA-2), a Golgicide A (GCA)derivative, is the most active enantiomer of GCA.Golgicide A-2 displays high selectivity andefficiency in killing An. stephensi larvaeand can be used for the

31、research of dengue virusrelated diseases.Purity: 99.17%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.60%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/hederasaponin-b.html Hederasa

32、ponin HYPERLINK https:/www.MedChemE/hederasaponin-b.html HYPERLINK https:/www.MedChemE/hederasaponin-b.html B HYPERLINK https:/www.MedChemE/hederasaponin-b.html HYPERLINK https:/www.MedChemE/Lanatoside-C.html Lanatoside HYPERLINK https:/www.MedChemE/Lanatoside-C.html HYPERLINK https:/www.MedChemE/La

33、natoside-C.html CCat. No.: HY-N0306 Cat. No.: HY-B1030Hederasaponin B, isolated from Hedera helix, hasbroad-spectrum antiviral activity against varioussubgenotypes of Enterovirus 71 (EV71).Lanatoside C is a cardiac glycoside, can be usedin the treatment of congestive heart failure andcardiac arrhyth

34、mia.Lanatoside C has an IC50 of0.19 M for dengue virus infection in HuH-7 cells.Purity: 98%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.81%Clinical Data: LaunchedSize: 10 mM 1 mL, 10 mg HYPERLINK https:/www.MedChemE/ly2334737.html LY2334737 HYPERLINK https:/www.MedChemE/ly233473

35、7.html HYPERLINK https:/www.MedChemE/mosloflavone.html MosloflavoneCat. No.: HY-13672 Cat. No.: HY-N2036LY2334737 is an nucleoside analog and is an orallyactive prodrug of Gemcitabine. LY2334737 exhibitsinhibitory activity against enterovirus A71(EV-A71) infection. LY2334737 has antiviral andantican

36、cer effects.Mosloflavone is a flavonoid isolated fromScutellaria baicalensis Georgi with anti-EV71activity. Mosloflavone inhibits VP2 virusreplication and protein expression during theinitial stage of virus infection and inhibitsviral VP2 capsid protein synthesis.Purity: 99.02%Clinical Data: Phase 1

37、Size: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mgPurity: 99.19%Clinical Data: No Development ReportedSize: 5 mg, 10 mgwww.MedChemE 3 HYPERLINK https:/www.MedChemE/nhc-diphosphate.html NHC-diphosphate HYPERLINK https:/www.MedChemE/nhc-diphosphate.html HYPERLINK https:/www.MedChemE/nhc-diphosphate-triammon

38、ium.html NHC-diphosphate HYPERLINK https:/www.MedChemE/nhc-diphosphate-triammonium.html HYPERLINK https:/www.MedChemE/nhc-diphosphate-triammonium.html triammoniumCat. No.: HY-135867D Cat. No.: HY-135867FNHC-diphosphate is an activephosphorylated intracellularmetabolite of -d-N4-Hydroxycytidine (NHC)

39、(HY-125033) as a diphosphate form. NHC is apyrimidine ribonucleoside and behaves as a potentanti-virus agent.NHC-triphosphate triammonium is an activephosphorylated intracellular metabolite of-d-N4-Hydroxycytidine (NHC) (HY-125033) as atriphosphate form.Purity: 98.80%Clinical Data: No Development Re

40、portedSize: 1 mg, 5 mg, 10 mgPurity: 98.88%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/nhc-triphosphate.html NHC-triphosphate HYPERLINK https:/www.MedChemE/nhc-triphosphate.html HYPERLINK https:/www.MedChemE/nhc-triphosphate-tetraammonium.html NHC-trip

41、hosphate HYPERLINK https:/www.MedChemE/nhc-triphosphate-tetraammonium.html HYPERLINK https:/www.MedChemE/nhc-triphosphate-tetraammonium.html tetraammoniumCat. No.: HY-135867 Cat. No.: HY-135867ENHC-triphosphate is an active phosphorylatedintracellular metabolite of-d-N4-Hydroxycytidine (NHC) (HY-125

42、033) as atriphosphate form. NHC-triphosphate is a weakalternative substrate for the viral polymeraseand can be incorporated into HCV replicon RNA.NHC-triphosphate tetraammonium is an activephosphorylated intracellular metabolite of-d-N4-Hydroxycytidine (NHC) (HY-125033) as atriphosphate form.Purity:

43、 99.80%Clinical Data: No Development ReportedSize: 1 mgPurity: 96.05%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/nhc-triphosphate-tetrasodium.html NHC-triphosphate HYPERLINK https:/www.MedChemE/nhc-triphosphate-tetrasodium.html HYPERLINK https:/www.Med

44、ChemE/nhc-triphosphate-tetrasodium.html tetrasodiumCat. No.: HY-135867A HYPERLINK https:/www.MedChemE/norwogonin.html Norwogonin(5,7,8-Trihydroxyflavone) Cat. No.: HY-N2562NHC-triphosphate tetrasodium is an activephosphorylated intracellular metabolite of-d-N4-Hydroxycytidine (NHC) (HY-125033) as at

45、riphosphate form.Norwogonin, isolated from Scutellaria baicalensisGeorgi, possesses antiviral activity againstEnterovirus 71 (EV71) with an IC of 31.83 g/ml.50Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYP

46、ERLINK https:/www.MedChemE/pd-169316.html PD HYPERLINK https:/www.MedChemE/pd-169316.html HYPERLINK https:/www.MedChemE/pd-169316.html 169316 HYPERLINK https:/www.MedChemE/pd-169316.html HYPERLINK https:/www.MedChemE/pirlindole.html PirlindoleCat. No.: HY-10578 Cat. No.: HY-100679PD 169316 is a pote

47、nt, cell-permeable andselective p38 MAP kinase inhibitor, with IC of5089 nM. PD169316 selectively inhibits the kinaseactivity of the phosphorylated p38 withouthindering upstream kinases to phosphorylate p38.Pirlindole is a selective and reversible MAO-Ainhibitor. Pirlindole is also an inhibitor ofen

48、terovirus-D68 and coxsackievirus B3 (CV-B3).Purity: 98.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 10 mg, 50 mg, 100 mg, 500 mgPurity: 98%Clinical Data: LaunchedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Pirodavir.html Pirodavir HYPERLINK https:/www.MedChemE/Pirodavir.html HYPERLIN

49、K https:/www.MedChemE/Pleconaril.html Pleconaril(R77975) Cat. No.: HY-13784 (VP 63843; Win 63843) Cat. No.: HY-19952Pirodavir is a potent, broad-spectrum picornavirusinhibitor, and is highly active against both groupA and group B rhinovirus serotypes. Pirodavir isvery potent in a virus yield reducti

50、on assay(IC =2.3 nM).90Pleconaril is a capsid inhibitor used previouslyto treat enterovirus infections. Pleconaril iseffective in inhibiting replication with an IC50of 50 nM.Purity: 99.20%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mgPurity: 99.96%Clinical Data: Phase 2Si

51、ze: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg4 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/pleconaril-d4.html Pleconaril-d4(VP 63843-d4; Win 63843-d4) Cat. No.: HY-19952S HYPERLINK https:/www.MedChemE/Pocapavir.html Pocapavir(SCH-48973; V-073) Cat. No.

52、: HY-104074Pleconaril-d4 is deuterium labeled Pleconaril.Pocapavir (SCH-48973) is an orally active capsidinhibitor. Pocapavir prevents virion uncoatingupon entry into the cell. Pocapavir has antiviralactivity against polioviruses. Pocapavir alsoinhibits enterovirus infections.Purity: 98%Clinical Dat

53、a: No Development ReportedSize: 1 mg, 5 mgPurity: 99.14%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg, 100 mg HYPERLINK https:/www.MedChemE/prunin.html Prunin(Naringenin 7-0-glucoside) Cat. No.: HY-N1549 HYPERLINK https:/www.MedChemE/rupintrivir.html Rupintrivir(AG7088)

54、Cat. No.: HY-106161Prunin is a potent inhibitor of human enterovirusA71 (HEVA71). Prunin shows strong inhibitoryactivity against protein tyrosine phosphatase 1B(PTP1B), with an IC of 5.5 M.50Rupintrivirvr (AG7088), an antiviral drug, is apotent, selective and irreversible inhibitor ofhuman rhinoviru

55、s (HRV) 3C protease.Purity: 99.92%Clinical Data: No Development ReportedSize: 5 mg, 10 mgPurity: 99.0%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg HYPERLINK https:/www.MedChemE/rupintrivir-d4.html Rupintrivir-d4(AG7088-d4) Cat. No.: HY-106161S HYPERLINK https:/www.MedChemE/ttp-

56、8307.html TTP-8307Cat. No.: HY-124806Rupintrivir-d4 (AG7088-d4) is the deuteriumlabeled Rupintrivir. Rupintrivirvr (AG7088), anantiviral drug, is a potent, selective andirreversible inhibitor of human rhinovirus(HRV) 3C protease.TTP-8307 is a potent inhibitor of the replicationof several rhino- and

57、enteroviruses. TTP-8307inhibits coxsackievirus B3 (CVB3; EC =1.2 M)50and poliovirus by interfering with the synthesisof viral RNA. TTP-8307 exerts antiviral activitythrough oxysterol-binding protein (OSBP).Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.70%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10