附表二、病原微生物依其危險(xiǎn)性為基礎(chǔ)之分類

1、附表二、病原微生物依其危險(xiǎn)性為基礎(chǔ)之分類（本表參考1999年5月版NIH Guidelines for research involving recombinant DNA molecules訂定，2003年5月編審委員再次討論增修）甲、第一級(jí)危險(xiǎn)群（Risk group 1 , RG1）微生物第一級(jí)危險(xiǎn)群微生物與人類健康成人之疾病無關(guān)。例如不產(chǎn)生內(nèi)孢子之Bacillus licheniformis, Escherichia coli-K12, adeno-associated virus第一型至第四型，及重組的不含潛在致癌基因產(chǎn)物或毒素之a(chǎn)deno-associated virus，且在無輔

2、助病毒存在下進(jìn)行培養(yǎng)。乙、第二級(jí)危險(xiǎn)群（Risk group 2 , RG2）微生物第二級(jí)危險(xiǎn)群微生物在人類所引起的疾病很少是嚴(yán)重的，而且通常有預(yù)防及治療的方法。(一)細(xì)菌包括披衣菌1.Acinetobacter baumannii（以前稱為Acinetobacter calcoaceticus）2.Actinobacillus3.Actinomyces pyogenes（以前稱為Corynebacterium pyogenes）4.Aeromonas hydrophila5.Amycolata autotrophica6.Archanobacterium haemolyticum（以前稱為C

3、orynebacterium haemolyticum）7.Arizona hinshawii（所有血清型）8.Bacillus anthracis9.Bartonella henselae, B. quintana, B. vinsonii 10.Bordetella包括B. pertussis 11.Borrelia recurrentis, B. burgdorferi 12.Burkholderia（以前稱為Pseudomonas species；列於第三級(jí)危險(xiǎn)群者除外） 13.Campylobacter coli, C. fetus, C. jejuni 14.Chlamydia p

4、sittaci, C. trachomatis, C. pneumoniae 15.Clostridium botulinum, Cl. chauvoei, Cl. haemolyticum, Cl. histolyticum, Cl. novyi, Cl. septicum, Cl. tetani 16.Corynebacterium diphtheriae, C. pseudotuberculosis, C. renale 17.Dermatophilus congolensis 18.Edwardsiella tarda 19.Erysipelothrix rhusiopathiae 2

5、0.Escherichia coli（所有腸致病性、腸致毒性、腸侵襲性及攜帶有K1抗原的菌株，包括E. coli O157：H7） 21.Haemophilus ducreyi, H. influenzae 22.Helicobacter pylori 23.Klebsiella（除K. oxytoca（RG1）以外之所有菌株） 24.Legionella包括L. pneumophila 25.Leptospira interrogans（所有血清型） 26.Listeria 27.Moraxella 28.Mycobacterium（除了列於第三級(jí)危險(xiǎn)群者）包括M. avium comple

6、x, M. asiaticum, M. bovis BCG vaccine strain, M. chelonei, M. fortuitum, M. kansasii, M. leprae, M. malmoense, M. marinum, M. paratuberculosis, M. scrofulaceum, M. simiae, M. szulgai, M. ulcerans, M. xenopi 29.Mycoplasma（M. mycoides及 M. agalactiae除外） 30.Neisseria gonorrhoeae, N. meningitidis 31.Noca

7、rdia asteroides, N. brasiliensis, N. otitidiscaviarum, N. transvaiensis 32.Rhodococcus equi 33.Salmonella包括S. arizonae, S. cholerasuis, S. enteritidis, S. gallinarum-pullorum, S. meleagridis, S. paratyphi, A, B, C, S. typhi, S. typhimurium 34.Shigella包括S. boydii, S. dysenteriae, type 1, S. flexneri,

8、 S. sonnei 35.Sphaerophorus necrophorus 36.Staphylococcus aureus 37.Streptobacillus moniliformis 38.Streptococcus包括S. pneumoniae, S. pyogenes 39.Treponema pallidum, T. carateum 40.Vibrio cholerae, V. parahemolyticus, V. vulnificus 41.Yersinia enterocolitica（二）真菌1.Blastomyces dermatitidis2.Cladospori

9、um bantianum, C.（Xylohypha）trichoides3.Cryptococcus neoformans 4.Dactylaria galopava（Ochroconis gallopavum）5.Epidermophyton6.Exophiala（Wangiella）dermatitidis7Fonsecaea pedrosoi8.Microsporum9.Paracoccidioides braziliensis 10.Penicillium marneffei 11.Sporothrix schenckii 12.Trichophyton（三）寄生蟲1.Ancylos

10、toma human hookworms包括A. duodenale, A. ceylanicum2.Ascaris包括Ascaris lumbricoides suum3.Babesia包括B. divergens, B. microti4.Brugia filaria worms包括B. malayi, B. timori5.Coccidia6.Cryptosporidium包括C. parvum7.Cysticercus cellulosae（hydatid cyst, larva of T. solium）8.Echinococcus 包括E. granulosis, E. multi

11、locularis, E. vogeli9.Entamoeba histolytica 10.Enterobius 11.Fasciola包括F. gigantica, F. hepatica 12.Giardia包括G. lamblia 13.Heterophyes 14.Hymenolepis包括H. diminuta, H. nana 15.Isospora 16.Leishmania包括L. braziliensis, L. donovani, L. ethiopia, L. major, L. mexicana, L. peruvania, L. tropica 17.Loa loa

12、 filaria worms 18.Microsporidium 19.Naegleria fowleri 20.Necator human hookworms包括N. americanus 21.Onchocerca filaria worms包括O. volvulus 22.Plasmodium包括引起猿猴類疾病之P. cynomologi, P. falciparum, P. malariae, P. ovale, P. vivax 23.Sarcocystis包括S. sui hominis 24.Schistosoma包括S. haematobium, S. intercalatum

13、, S. japonicum, S. mansoni, S. mekongi 25.Strongyloides包括S. stercoralis 26.Taenia solium 27.Toxocara包括T. canis 28.Toxoplasma包括T. gondii 29.Trichinella spiralis 30.Trypanosoma包括T. brucei brucei, T. brucei gambiense, T. brucei rhodesiense, T. cruzi 31.Wuchereria bancrofti filaria worms（四）病毒1.Adenoviru

14、ses, human-all types2.Arenavirusesa. Lymphocytic choriomeningitis virus（non-neurotropic strains）b. Tacaribe virus complexc.其他被特別引述而列名之病毒3.Bunyavirusesa. Bunyamwera virusb. Rift Valley fever virus vaccine strain MP-12c.其他被特別引述而列名之病毒4.Calciviruses5.Coronaviruses（SARS-Associated Coronaviruses列於第三級(jí)危險(xiǎn)群除外

15、）6.Flaviviruses（Togaviruses）- Group B Arbovirusesa. Dengue virus serotypes 1, 2, 3, and 4b. Japanese encephalitis virusc. Yellow fever virus vaccine strain 17Dd. 其他被特別引述而列名之病毒7.Hepatitis A, B, C, D, and E viruses8.Herpesviruses（Herpesvirus simiae（Monkey B virus）除外）a. Cytomegalovirusb. Epstein Barr v

16、irusc. Herpes simplex types 1 and 2d. Herpes zostere. Human herpesvirus types 6 and 79.Orthomyxovirusesa. Influenza viruses types A, B, and Cb.其他被特別引述而列名之壁蝨攜帶正黏液病毒 10.PapovavirusesAll human papilloma viruses 11.Paramyxovirusesa. Newcastle disease virusb. Measles virusc. Mumps virusd. Parainfluenza v

17、iruses types 1, 2, 3, and 4e. Respiratory syncytial virus 12.ParvovirusesHuman parvovirus（B19） 13.Picornavirusesa. Coxsackie viruses types A and Bb. Echoviruses-all typesc. Rhinoviruses-all types 14.Poxviruses （Monkeypox virus及被管制的Alastrim, Smallpox與Whitepox除外） 15.Reoviruses包括Coltivirus, human Rotav

18、irus及Orbivirus（Colorado tick fever virus） 16.Rhabdovirusesa. Rabies virus-all strainsb. Vesicular stomatitis virus-實(shí)驗(yàn)室調(diào)適的病毒株包括VSV-Indiana, San Juan及Glasgow 17.Togaviruses（參見Alphaviruses及Flaviviruses）Rubivirus（rubella）丙、第三級(jí)危險(xiǎn)群（Risk group 3 , RG3）微生物第三級(jí)危險(xiǎn)群微生物在人類可以引起嚴(yán)重或致死的疾病，可能有預(yù)防及治療之方法。(一)細(xì)菌包括立克次氏菌1.B

19、artonella2.Brucella包括B. abortus, B. canis, B. suis3.Burkholderia（Pseudomonas）mallei, B. pseudomallei4.Coxiella burnetii5.Francisella tularensis6.Mycobacterium bovis（但BCG除外）, M. tuberculosis7.Pasteurella multocida type B - "buffalo" and other virulent strains8.Rickettsia akari, R. australis

20、, R. canada, R. conorii, R. prowazekii, R. rickettsii, R. siberica, R. tsutsugamushi, R. typhi（R. mooseri）9.Yersinia pestis(二)真菌1.Coccidioides immitis（sporulating cultures；contaminated soil）2.Histoplasma capsulatum, H. capsulatum var. duboisii(三)寄生蟲無(四)病毒與變性蛋白（Prions）1.Alphaviruses（Togaviruses）- Gro

21、up A Arbovirusesa. Eastern equine encephalomyelitis virusb. Semliki Forest virusc. St. Louis encephalitis virusd.Venezuelan equine encephalomyelitis virus（含TC-83疫苗株）e. Western equine encephalomyelitis virusf. 其他被特別引述而列名之病毒2.Arenavirusesa. Flexalb. Lymphocytic choriomeningitis virus（LCM）（neurotropic

22、strains）3.Bunyavirusesa. Hantaviruses包括Hantaan virusb. Rift Valley fever virus4.Coronavirusesa. SARS-associated Coronaviruses (SARS-CoV)-相關(guān)實(shí)驗(yàn)操作必須嚴(yán)格遵照本守則附表八之規(guī)定5.Flaviviruses（Togaviruses）- Group B Arbovirusesa. West Nile Virus b. Yellow fever virusc. 其他被特別引述而列名之病毒6.Picornavirusesa. Polioviruses-all ty

23、pes, wild and attenuated7.PoxvirusesMonkeypox virus8.PrionsTransmissible spongioform encephalopathies（TME）agents（Creutzfeldt-Jacob disease and kuru agents）9.Retrovirusesa. Human immunodeficiency virus（HIV）types 1 and 2b. Human T cell lymphotropic virus（HTLV）types 1 and 2c. Simian immunodeficiency vi

24、rus（SIV） 10.RhabdovirusesVesicular stomatitis virus丁、第四級(jí)危險(xiǎn)群（Risk group 4 , RG4）微生物第四級(jí)危險(xiǎn)群微生物在人類可以引起嚴(yán)重或致死的疾病，但通常無預(yù)防及治療之方法。(一)細(xì)菌無(二)真菌無(三)寄生蟲無(四)病毒1.Arenavirusesa. Guanarito virusb. Lassa virusc. Junin virusd. Machupo viruse. Sabia2.Bunyaviruses（Nairovirus）Crimean-Congo hemorrhagic fever virus3.Filovirusesa. Ebola virusb. Marburg virus4.Flaviruses（Togaviruses）- Group B ArbovirusesTick-borne encephalitis virus complex包括Absetterov, Central European encephalitis, Hanzalova, Hypr, Kumlinge, Kyasanur Forest disease, Omsk hemorrhagic fev