藥學(xué)英語(yǔ)之減肥藥原理講解ppt課件

1、Generic Name:Sibutramine hydrochlorideProduct Name: Reductil/Ectiva 1;.Product name: Qu MeiGeneric Name: Sibutramine hydrochloride2;. SibutramineFormula: C17H26Cl N molecule Chemical structure3;. Indications: obesity (肥胖癥，多脂肥胖癥，多脂)！4;. pharmacologySibutramine is a neurotransmitter(神經(jīng)遞質(zhì)神經(jīng)遞質(zhì)) reuptake

2、 （重吸收）（重吸收）inhibitor that reduces the reuptake of serotonin（血清素（血清素), norepinephrine（去甲腎上腺素）（去甲腎上腺素） , and dopamine , thereby increasing the levels of these substances in synaptic clefts （突觸間隙）（突觸間隙）and helping enhance satiety（飽滿感）（飽滿感）; the serotonergic（5-羥色胺能羥色胺能） action, in particular, is thought

3、 to influence appetite. 5;. contraindicationsSibutramine is contraindicated in:1 Psychiatric(精神病學(xué)的精神病學(xué)的) conditions as bulimia nervosa（神經(jīng)性貪食癥）（神經(jīng)性貪食癥）, anorexia（厭食（厭食癥）癥）, serious depression or preexisting mania（狂躁癥）（狂躁癥） 2 Patients below 18 years of age 3 Concomitant（伴行的，并發(fā)的）（伴行的，并發(fā)的） treatment wit

4、h a MAO inhibitor（單胺氧化酶抑制劑）（單胺氧化酶抑制劑）, antidepressant or other centrally active drugs, particularly other anoretics（消瘦劑，減食欲（消瘦劑，減食欲劑）劑） 4 Hypertension that is not sufficiently controlled (caution in controlled hypertension) 5 Existing pulmonary hypertension （肺動(dòng)脈高血壓）（肺動(dòng)脈高血壓）6 Pregnant and lactating（泌

5、乳）（泌乳） women 6;. side effects!Frequently encountered side effects areFrequently encountered side effects are: dry mouth, paradoxically increased appetite, nausea(惡心惡心), strange taste in the mouth, upset stomach, constipation（便秘）（便秘）, trouble sleeping, dizziness, drowsiness（困倦）（困倦）, menstrual cramps/

6、pain, headache, flushing（面紅）（面紅）, or joint/muscle pain.7;.The following side effects are infrequent but serious and require immediate medical attention: cardiac arrhythmias（心律不齊）（心律不齊）, paresthesia（感覺(jué)異常）（感覺(jué)異常）, mental/mood changes (e.g., excitement, restlessness, confusion, depression, rare thoughts

7、 of suicide).Symptoms that require urgent medical attention are seizures（癲癇發(fā)作癲癇發(fā)作）, problems urinating（排尿）（排尿）, abnormal bruising（碰傷）（碰傷） or bleeding,hematemesis（嘔血）（嘔血）, fever and rigors（僵直）（僵直）, chest pain, hemiplegia,（半身不遂）（半身不遂） abnormal vision, dyspnea（呼吸困難）（呼吸困難） and edema.（水腫）（水腫）8;. Suggestion !Dont take QU Mei or any kind of medicine whose main ingredient is Sibutramine.More exercise and less food is the