Conteltinib-tetrahydrochloride-CT-707-tetrahydrochloride-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEConteltinibtetrahydrochlorideCat.No.:HY-109084ASynonyms:CT-707tetrahydrochloride分?式:C??H??Cl?N?O?S分?量:781.67作?靶點:FAK作?通路:ProteinTyrosineKinase/RTK儲存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實驗DMSO:100mg/mL(127.93mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.2793mL6.3966mL12.7931mL5mM0.2559mL1.2793mL2.5586mL10mM0.1279mL0.6397mL1.2793mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性Conteltinibtetrahydrochloride(CT-707tetrahydrochloride)Conteltinib(HY-109084)的四鹽酸鹽形式。ConteltinibtetrahydrochlorideFAK(IC50=1.6nM)、ALK和Pyk2的抑制劑。Conteltinibtetrahydrochloride與Cabozantinib(HY-13016)聯(lián)合使?，具有協(xié)同抗腫瘤作?。REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].WangDD,etal.CT-707,aNovelFAKInhibitor,SynergizeswithXL184toSuppressHepatocellularCarcinomabyBlockingXL184-InducedFAKActivation.MolCancerTher.2016Dec;15(12):2916-2925.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-