Rhoifolin-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERhoifolin(Standard)Cat.No.:HY-N0755RCASNo.:17306-46-6分?式:C??H??O??分?量:578.52作?靶點(diǎn):InsulinReceptor;GLUT;NF-κB;p38MAPK;Autophagy作?通路:ProteinTyrosineKinase/RTK;MembraneTransporter/IonChannel;NF-κB;MAPK/ERKPathway;Autophagy儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Rhoifolin(Standard)Rhoifolin的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Rhoifolin?種酮糖苷，可從野洋漆分離。Rhoifolin通過增強(qiáng)脂聯(lián)素分泌、胰島素受體-β(insulinreceptor-β)的酪氨酸磷酸化和GLUT4易位來發(fā)揮抗糖尿病作?。Rhoifolin通過對炎癥介質(zhì)的多層次調(diào)控發(fā)揮抗炎作?。Rhoifolin通過RANKL誘導(dǎo)的NF-κB和MAPK途徑改鈦顆粒刺激的?溶解并減弱破?細(xì)胞?成。Rhoifolin對多種癌細(xì)胞系也具有細(xì)胞毒性活性。REFERENCES[1].RaoYK,etal.Insulin-MimeticActionofRhoifolinandCosmosiinIsolatedfromCitrusgrandis(L.)OsbeckLeaves:EnhancedAdiponectinSecretionandInsulinReceptorPhosphorylationin3T3-L1Cells.EvidBasedComplementAlternatMed.2011;2011:624375.[2].LiaoS,etal.Rhoifolinamelioratestitaniumparticle-stimulatedosteolysisandattenuatesosteoclastogenesisviaRANKL-inducedNF-κBandMAPKpathways.JCellPhysiol.2019Aug;234(10):17600-17611.[3].Eldahshan.O.A,etal.Rhoifolin;APotentAntiproliferativeEffectonCancerCellLines.JournalofPharmaceuticalResearchInternational,2012,3(1),pp.46-53.[4].OmamaE.El-Shawi,etal.ProtectiveEffectofRhoifolinonGammaIrradiationInducedCardiacDysfunctionsinAlbinoMice.Feb15,2014.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>