Proadifen-hydrochloride-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEProadifenhydrochloride(Standard)Cat.No.:HY-B1311RCASNo.:62-68-0分?式:C??H??ClNO?分?量:389.96作?靶點(diǎn):CytochromeP450;MonoamineOxidase;Bcl-2Family;Survivin;PARP作?通路:MetabolicEnzyme/Protease;NeuronalSignaling;Apoptosis;CellCycle/DNADamage;Epigenetics儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Proadifen(hydrochloride)(Standard)Proadifen(hydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Proadifen(SKF-525A)hydrochloride?種?競(jìng)爭(zhēng)性CytochromeP450抑制劑，其IC50值為19μM。Proadifenhydrochloride降低??單胺氧化酶A(MAO-A)活性，并逆轉(zhuǎn)Imipramine(HY-B1490A)和Desipramine(HY-B1272A)抗抑郁樣?為。Proadifenhydrochloride也降低肝微粒體N,N-dimethyltryptamine(DMT)代謝，抑制N-demethylation和Acridone(HY-W007771)的形成。Proadifenhydrochloride在??中增加Lipopolysaccharide(LPS)(HY-D1056)誘導(dǎo)的發(fā)燒并加劇ProstaglandinE2(PGE2)(HY-101952)?平。Proadifenhydrochloride有望?于代謝相關(guān)疾病，巢癌，炎癥和多巴胺神經(jīng)元相關(guān)疾病的研究[1][2][3][4][5][6]。REFERENCES[1].GrinchiiD,etal.InhibitionofcytochromeP450byproadifendiminishestheexcitabilityofbrainserotoninneuronsinrats[J].GenPhysiolBiophys.2018Sep;37(6):711-713.[2].Eckern?sE,etal.N,N-dimethyltryptamineformsoxygenatedmetabolitesviaCYP2D6-aninvitroinvestigation[J].Xenobiotica.2023Dec;53(8-9):515-522.[3].RobertsonIG,etal.InhibitionbySKF-525Aofthealdehydeoxidase-mediatedmetabolismoftheexperimentalantitumouragentacridinecarboxamide[J].BiochemPharmacol.1993May25;45(10):2159-62.[4].PaliokhaR,etal.InhibitionofcytochromeP450withproadifenalterstheexcitabilityofbraincatecholamine-secretingneurons[J].GenPhysiolBiophys.2022May;41(3):255-262.[5].KozakW,etal.Proadifen(SKF-525A),aninhibitorofcytochromeP-450,augmentsLPS-inducedfeverandexacerbatesprostaglandin-E2levelsintherat[J].JournalofThermalBiology,2000,25(1-2):45-50.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[6].Jend?elovskyR,etal.Proadifensensitizesresistantovarianadenocarcinomacellstocisplatin[J].ToxicologyLetters,2016,243:56-66.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonl