Oseltamivir-acid-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEOseltamiviracid(Standard)Cat.No.:HY-13318RCASNo.:187227-45-8分?式:C??H??N?O?分?量:284.35作?靶點(diǎn):InfluenzaVirus;DrugMetabolite作?通路:Anti-infection;MetabolicEnzyme/Protease儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性O(shè)seltamiviracid(Standard)Oseltamiviracid的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Oseltamiviracid(GS4071)，Oseltamivirphosphate的活性代謝產(chǎn)物,流感病毒神經(jīng)氨酸酶(IC50=2nM)的?服?物有效的，選擇性的抑制劑，對(duì)流感病毒A和B都有活性[1][2]。IC50&TargetIC50:2nM(influenzavirusneuraminidase)REFERENCES[1].LiW,etal.IdentificationofGS4104asanorallybioavailableprodrugoftheinfluenzavirusneuraminidaseinhibitorGS4071.AntimicrobAgentsChemother.1998Mar;42(3):647-53.[2].GhoshGC,etal.Oseltamivircarboxylate,theactivemetaboliteofoseltamivirphosphate(Tamiflu),detectedinsewagedischargeandriverwaterinJapan.EnvironHealthPerspect.2010Jan;118(1):103-7.[3].FerrarisO,etal.Sensitivityofinfluenzavirusestozanamivirandoseltamivir:astudyperformedonvirusescirculatinginFrancepriortotheintroductionofneuraminidaseinhibitorsinclinicalpractice.AntiviralRes.2005Oct;68(1):43-8.[4].GubarevaLV,etal.Comparisonoftheactivitiesofzanamivir,oseltamivir,andRWJ-270201againstclinicalisolatesofinfluenzavirusandneuraminidaseinhibitor-resistantvariants.AntimicrobAgentsChemother.2001Dec;45(12):3403-8.[5].YenHL,etal.VirulencemaydeterminethenecessarydurationanddosageofoseltamivirtreatmentforhighlypathogenicA/Vietnam/1203/04influenzavirusinmice.JInfectDis.2005Aug15;192(4):665-72.[6].HoffmannG,etal.Nonclinicalpharmacokineticsofoseltamivirandoseltamivircarboxylateinthecentralnervoussystem.AntimicrobAgentsChemother.2009Nov;53(11):4753-61.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82