Noscapine-Standard-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENoscapine(Standard)Cat.No.:HY-13716RCASNo.:128-62-1分?式:C??H??NO?分?量:413.42作?靶點(diǎn):OpioidReceptor;Apoptosis作?通路:GPCR/GProtein;NeuronalSignaling;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Noscapine(Standard)Noscapine的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Noscapine((S,R)-Noscapine)?種具有?服活性的苯酞異喹啉?物堿，具有強(qiáng)效鎮(zhèn)咳作?。Noscapine通過激活sigma阿?類受體(sigmaopioidreceptors)發(fā)揮鎮(zhèn)咳作?，?種?競爭性Bradykinin抑制劑。Noscapine破壞微管動?學(xué)，誘導(dǎo)細(xì)胞有絲分裂停滯和凋亡(apoptosis)以及活性。Noscapine具有抗癌，神經(jīng)保護(hù)，抗炎活性，并且可以穿越?腦屏障。IC50&TargetSigmaopioidreceptors[4]Bradykinin[5]Apoptosis[1]REFERENCES[1].JarenWLanden,etal.NoscapineCrossestheBlood-BrainBarrierandInhibitsGlioblastomaGrowth.ClinCancerRes.2004Aug1;10(15):5187-201.[2].YunfanYang,etal.CYLDRegulatesNoscapineActivityinAcuteLymphoblasticLeukemiaviaaMicrotubule-DependentMechanism.Theranostics.2015Mar2;5(7):656-66.[3].VartikaTomar,etal.NoscapineandItsAnalogsasChemotherapeuticAgent:CurrentUpdates.CurrTopMedChem.2017;17(2):174-188.[4].BiancaLokhorst,etal.InteractionofOTCDrugNoscapineandAcenocoumarolandPhenprocoumon.BrJClinPharmacol.2019May;85(5):1041-1043.[5].SAEbrahimi,etal.InteractionofNoscapineWiththeBradykininMediationoftheCoughResponse.ActaPhysiolHung.2003;90(2):147-55.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792