GB/T 44480-2024化學(xué)品麗斑麻蜥急性經(jīng)口毒性試驗(yàn)

ICS

13.300

CCS

A80

中華人民共和國(guó)國(guó)家標(biāo)準(zhǔn)

GB/T44480—2024

化學(xué)品麗斑麻蜥急性經(jīng)口毒性試驗(yàn)

Chemicals—Eremiasargusacuteoraltoxicitytest

2024-09-29發(fā)布2025-04-01實(shí)施

國(guó)家市場(chǎng)監(jiān)督管理總局發(fā)布

國(guó)家標(biāo)準(zhǔn)化管理委員會(huì)

GB/T44480—2024

目次

前言

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Ⅲ

1

范圍

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2

規(guī)范性引用文件

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3

術(shù)語(yǔ)和定義

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4

試驗(yàn)概述

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5

試驗(yàn)方法

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5.1

材料和儀器

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5.2

樣品制備

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5.3

試驗(yàn)操作

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5.4

結(jié)果計(jì)算與表示

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5.5

質(zhì)量保證和質(zhì)量控制

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6

試驗(yàn)報(bào)告

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3

附錄A（資料性）麗斑麻蜥的馴養(yǎng)繁殖條件及方法錄A方法

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4

附錄B（資料性）溶液配制及試驗(yàn)觀察記錄表

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7

參考文獻(xiàn)

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Ⅰ

GB/T44480—2024

前言

本文件按照GB/T1.1—2020《標(biāo)準(zhǔn)化工作導(dǎo)則第1部分：標(biāo)準(zhǔn)化文件的結(jié)構(gòu)和起草規(guī)則》的規(guī)

定起草。

請(qǐng)注意本文件的某些內(nèi)容可能涉及專(zhuān)利。本文件的發(fā)布機(jī)構(gòu)不承擔(dān)識(shí)別專(zhuān)利的責(zé)任。

本文件由全國(guó)危險(xiǎn)化學(xué)品管理標(biāo)準(zhǔn)化技術(shù)委員會(huì)（SAC/TC251）提出并歸口。

本文件起草單位：中國(guó)科學(xué)院生態(tài)環(huán)境研究中心、中檢科?。ㄌ旖颍z驗(yàn)檢測(cè)有限責(zé)任公司、中國(guó)

檢驗(yàn)檢疫科學(xué)研究院。

本文件主要起草人：常靜、王會(huì)利、萬(wàn)斌、謝昀、李建中、周麗麗、劉春艷、王利利。

Ⅲ

GB/T44480—2024

化學(xué)品麗斑麻蜥急性經(jīng)口毒性試驗(yàn)

1范圍

本文件描述了化學(xué)品對(duì)麗斑麻蜥急性經(jīng)口毒性試驗(yàn)的試驗(yàn)方法，規(guī)定了試驗(yàn)的材料、條件、操作、

質(zhì)量控制、數(shù)據(jù)處理、試驗(yàn)報(bào)告等的基本要求。

本文件適用于測(cè)試化學(xué)品對(duì)麗斑麻蜥的急性毒性效應(yīng)。

2規(guī)范性引用文件

下列文件中的內(nèi)容通過(guò)文中的規(guī)范性引用而構(gòu)成本文件必不可少的條款。其中，注日期的引用文

件，僅該日期對(duì)應(yīng)的版本適用于本文件；不注日期的引用文件，其最新版本（包括所有的修改單）適用

于本文件。

GB/T6682分析實(shí)驗(yàn)室用水規(guī)格和試驗(yàn)方法

GB/T31270.9—2014化學(xué)農(nóng)藥環(huán)境安全評(píng)價(jià)試驗(yàn)準(zhǔn)則第9部分：鳥(niǎo)類(lèi)急性毒性試驗(yàn)

3術(shù)語(yǔ)和定義

下列術(shù)語(yǔ)和定義適用于本文件。

3.1

半數(shù)致死劑量medianlethaldose；LD50

一次給予實(shí)驗(yàn)用動(dòng)物供試物后，引起實(shí)驗(yàn)用動(dòng)物總體中半數(shù)死亡的毒物統(tǒng)計(jì)學(xué)劑量。以實(shí)驗(yàn)用動(dòng)物

單位體重接受供試物的質(zhì)量表示。

3.2

最高無(wú)致死劑量maximumnonlethaldose；LD0

一次給予實(shí)驗(yàn)用動(dòng)物供試物后，不引起實(shí)驗(yàn)用動(dòng)物死亡的最高毒物統(tǒng)計(jì)學(xué)劑量。以實(shí)驗(yàn)用動(dòng)物單位

體重接受供試物的質(zhì)量表示。

3.3

最低全致死劑量minimumtotallethaldose；LD100

一次給予實(shí)驗(yàn)用動(dòng)物供試物后，引起實(shí)驗(yàn)用動(dòng)物全部死亡的最低毒物統(tǒng)計(jì)學(xué)劑量。以實(shí)驗(yàn)用動(dòng)物單

位體重接受供試物的質(zhì)量表示。

3.4

急性經(jīng)口毒性acuteoraltoxicity

一次經(jīng)口給予實(shí)驗(yàn)用動(dòng)物供試物后，動(dòng)物在短期內(nèi)（7d）出現(xiàn)的健康損害效應(yīng)。

3.5

供試物testsubstances

由各種元素組成的純