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TheHeadandNeck1BonesofthefaceandskullParietal[p?'ra??t(?)l]
頂骨Occipital[?k's?p?t?l]
枕Temporal['temp(?)r(?)l]
顳Mastoid['m?st??d]
乳突Externalauditorymeatus
外耳道[ek'st??n(?)l]['??d?t?r?][m?'e?t?s]Styloidprocess['sta?l??d]
莖突2BonesofthefaceandskullMandible['m?nd?bl]
下顎骨Vomer['v??m?]
犁骨Palatine['p?l?t?n]
腭骨Frontal額骨Glabella
[gl?'bel?]
眉間Nasal[?ne?zl]鼻骨Lacrimal
['l?kr?m?l]
淚骨Zygomaticbone[,za?ɡo'm?t?k]
顴骨Maxilla[m?k‘s?l?]
顎骨3MusclesofthefaceandskullOrbicularis
oculimuscle眼輪匝肌[?:,bikju'lε?ris]['?kjuli]Orbicularis
orismuscle口輪匝肌Sternocleidomastoidmuscle['st?:n?u,klaid?'m?st?id]胸鎖乳突肌superficialmusclesunderlyingmusclesPlatysmamuscle[pl?'tizm?]
頸闊肌Trapeziusmuscle[tr?'pi?z??s]
斜方肌Temporalismuscle[,temp?'re?l?s]
顳肌Massetermuscle[m?'si?t?]
咬肌4BoundariesofthetrianglesoftheneckPosteriortriangle['tra???g(?)l]頸后三角Anteriortriangle頸前三角Clavicularhead[kl?‘v?kj?l?]
鎖骨頭Sternalhead['st??n(?)l]
胸骨頭5ThyroidglandLarynx['l?r??ks]
喉Trachea['trek??]
氣管Clavicle['kl?v?k(?)l]
鎖骨Isthmus['?sm?s]
峽部Thyroidlaterallobes[?l?t?r?l][l??b]
甲狀腺側葉6LymphnodesoftheneckAnteriorauricular耳前[??'r?kj?l?]Posteriorauricular耳后Occipital[?k's?p?t?l]
枕Posteriorcervical頸后['s?v?kl]Supraclavicular
[sju:pr?kl?‘v?kj?l?]
鎖骨上Superficialcervical[?s?:v?kl]
頸淺Deepcervical頸深Tonsillar
['t?nsil?]
扁桃體Submaxillary
頜下Submental
頦下7EndocrineSystemWordsPineal松果體Hypothalamus[,ha?p?'θ?l?m?s]
下丘腦Pituitary[p?'tju??t(?)r?]
垂體Thyroid
甲狀腺Parathytoids
甲狀旁腺Thymus
胸腺Adrenal
腎上腺Pancreas胰腺Ovary
卵巢Testes
睪丸8EndocrineSystemWordsexocine,['?ks?kr?n]外分泌endocrine,
['end?(?)kr?n]內分泌secrete,[s?'kri?t]分泌gonad,['ɡon?d]性腺cortex,['k?rt?ks]皮質medullar[me'd?l?],髓質corticosteroid,[,k??t?k??'ster??d]
皮質類固醇glucocorticoid,[,ɡl?ko'k?rt?,k??d]
糖皮質激素cortisol['k??t?s?l],皮質醇mineralocorticoid
[,m?n?r?lo'k?rt?,k??d],鹽皮質激素aldosterone
[?l'd?st?r??n],醛固酮epinephrine[,ep?'nefri?n],腎上腺素norepinephrine,[,n??rep?‘nefri?n]去甲腎上腺素9EndocrineSystemWordsIslet['a?l?t]胰島細胞insulin['?ns?l?n]胰島素glucagon['glu?k?g(?)n]胰高血糖素anabolism[?‘n?b?l?z(?)m]合成代謝
Catabolism[k?'t?b?l?z(?)m]分解代謝hyperthyroidism,[,ha?p?'θa?r??d?z(?)m]
甲狀腺功能亢進hypothyroidism,[ha?p??'θa?r??d?z(?)m]
甲狀腺功能減退Tachycardia[t?k?‘kɑ?d??]心動過速
exophthalmos[,eks?f’θ?lm?s]突眼10PituitaryanatomyandimagingInterthalamicadhesion丘腦粘合Corpuscallosum[kɑ:‘l??s?m]胼胝體Mammillarybody[‘m?m?l?r?]乳頭體
Mesencephalon中腦[?mesen'sef?l?n]Pontine[‘p?nta?n]橋腦Medullaoblongata延髓[m?'d?l?][?bl??'ɡɑ:t?]spinal
cord脊髓[?spa?n?lk?:d]Sellaturcica蝶鞍Spheniod
sinus蝶竇
['sfi:n??d][?sa?n?s]Optic
nerve視神經(jīng)Pituitary
stalk垂體柄PinealSagittalplane11Pituitaryanatomyandimaging12Pituitaryanatomyandimaging13PituitaryanatomyandimagingCoronalplaneSellaturcica蝶鞍Spheniod
sinus蝶竇
['sfi:n??d][?sa?n?s]Optic
nerve視神經(jīng)Pituitary
stalk垂體柄Lateral
ventricle側腦室[?l?t?r?l?ventrikl]Basalnucleus基底節(jié)Cavernous
sinus[?k?v?n?s]海綿竇Internalcarotidartery[k?'r?t?d]14Pituitaryanatomyandimaging15Pituitaryanatomyandimaging16Pituitaryanatomyandimaging17Pituitaryanatomyandimaging18Pituitaryanatomyandimaging19Adrenalanatomyandimagingspine[spa?n]脊柱Abdominalaorta[e???:t?]腹主動脈Inferiorvenacava下腔靜脈Caudallobe尾葉20Adrenalanatomyandimaging21Adrenalanatomyandimaging22Adrenalanatomyandimaging23EndocrineGlandsThyroidGlandThethyroidglandislocatedinthelowerfrontpartoftheneck.Itproducesthyroidhormonesthatregulatethebody‘smetabolism.Italsoplaysaroleinbonegrowthanddevelopmentofthebrainandnervoussysteminchildren.Thepituitaryglandcontrolsthereleaseofthyroidhormones.Thyroidhormonesalsohelpmaintainnormalbloodpressure,heartrate,digestion,muscletone,andreproductivefunctions.24Thyroidhormone25HyperthyroidismAhypermetabolicbiochemicalstateItisamultisystemdiseasewithElevatedlevelsofFT4orFT3orbothWhatisthyrotoxicosis?Whatishyperthyroidism?Whatarethevariouscauses?Howtodifferentiatethecauses?Whatistheappropriatetreatment?26﹌﹏×﹌
Referstoavarietyofcausesofthyroidhormone(TH)hypersecretion,causingincreasedexcitabilityandmetabolichyperactivityinnervous,circulatory,digestiveandothersystemsasthemainmanifestation.ThyrotoxicosisGravesT3,T4production↑chroniclymphocyticthyroiditis(CLT)SubacutethyroiditisT3,T4release↑27GravesDiseaseThemostcommoncauseofthyrotoxicosis(50-60%)Organspecificauto-immunediseaseThemostimportantautoantibodyisThyroidStimulatingImmunoglobulin(TSI)orTSATSIactsasproxytoTSHandstimulatesT4andT3Antithyro
peroxidase(anti-TPO)antibodiesAntithyroglobulin(anti-TG)AntiMicrosomalandotherAutoimmunediseases-PerniciousAnemia,T1DM.28NucleotideScintigraphySubacutethyroiditisGraves29SubAcuteThyroiditis(SAT)SATisthenextmostcommonhyperthyroidism–15%T4andT3areextremelyelevatedinthisconditionImmunedestructionofthyroidduetoviralinfectionDestructivereleaseofpreformedthyroidhormoneThyroidglandispainfulandtenderonpalpationNuclearScintigraphyscan-noRIUintheglandTreatmentisNSAIDsandCorticosteroids30NormalSubacutethyroiditisGraveschroniclymphocyticthyroiditis,CLT31CommonSymptomsNervousness
['n?:v?sn?s]
焦急Anxiety[???za??ti]焦慮Increasedperspiration
[?p?:sp??re??n]多汗4.Heatintolerance怕熱5.Tremor[?trem?(r)]震顫
6.Hyperactivity多動7.Palpitations
[?p?lp??te??nz]
心悸8.Weightlossdespiteincreasedappetite消瘦食欲增加9.Reductioninmenstrualfloworoligo-menorrhea
月經(jīng)不穩(wěn)
32CommonSignsHyperactivity,Hyperkinesis[k??ni:s?s]多動/興奮Sinustachycardiaoratrial
arrhythmia[?eitri?l
??riemi?],atrial
fibrillation[?f?br?‘le???n],congestiveheartfailure[k?n’d?est?v]竇性心動過速/房性心律失常/房顫/心衰Systolichypertension,widepulsepressure收縮期高血壓/脈壓差大Warm,moist,softandsmoothskin-warmhandshake
熱潮濕5.Excessiveperspiration[?p?:sp??re??n]多汗6.Finetremorofoutstretchedhands[st‘ret?t]伸展細顫Largemuscleweakness,Diarrhea,Gynecomastia
肌肉無力/腹瀉/男性乳房發(fā)育33DiagnosisTypicalclinicalpresentationMarkedlysuppressedTSH(<0.05μIU/mL)ElevatedFT4andFT3
(MarkedlyinGraves)Thyroidantibodies–byElisa–anti-TPO,TSIECGtodemonstratecardiacmanifestationsNuclearScintigraphytodifferentiatethecauses34AlgorithmforHyperthyroidismMeasureTSHandFT4
TSH,FT4MeasureFT3Primary(T4)ThyrotoxicosisHighPituitaryAdenomaFNAC,NScanNormal
TSH,FT4N
TSH,FT4NTSH,FT4NT3ToxicosisSub-clinicalHyperFeaturesofGrave’sYesRx.Grave’sNoSingleAdenoma,MNGLowRAIU
RAIUSubAcuteThyroiditis,I2,↑ThyroxineF/uin6-12wks35TreatmentOptionsSymptomreliefmedicationsAntiThyroidDrugs–ATDMethimazole
(MTA)Propylthiouracil(PTU)RadioActiveIodinetreatment–RAIRx.Thyroidectomy–SubtotalorTotalNSAIDsandCorticosteroids–forSAT36SummaryofHyperthyroidismHyperthyroidismAge%EnlargedPainRAIUTreatmentGraves(TSIAbeye,dermo,bruit)20-4060%DiffuseNone↑↑ATD–18mToxicMNG>5020%LumpyPressure↑RAI,SurgerySingleAdenoma35-505%SingleNone±RAI,ATDSAcuteThyroiditisAnyage15%NoneYes↓↓NSAID,Ster.TSHismarkedlylow,FT4iselevated37EndocrineSystemReviewTheendocrinesystemconsistsofdiscreteindividualglandsandtissuesthatproduceandsecretechemicalmessengerscalledhormones.Hormonesenterthebloodstreamfordispersalthroughoutthebody.
Theyexerteffectsonlyonspecificcells,calledtargetcells,thatpossessreceptorsforthem.38HormonesReceptorsHormonesinfluencetargetcellsbybindingtoSpecificreceptors.ThehormonereceptorinteractionInitiatestheprocessoftransformingthechemicalmessageintotheresponseofthecell.39EndocrineSystemGlandsandHormonesInthistopicwewillreviewsomeofthewellestablishedendocrineglandsandtissues,someofthehormonestheyproduced,andasimplefunctionforeach.40GlandsandHormonesENDOCRINEGLANDHORMONESSECRETEDPinealGlandMelatoninPituitaryGlandGrowthhormone(GH)Thyroid-stimulatinghormone(TSH)Adrenocorticotropinhormone(ACTH)follicle-stimulatinghormone(FSH)Luteinizinghormone(LH)ProlactinVasopressin/Oxytocin41GlandsandHormonesENDOCRINEGLANDHORMONESSECRETEDhypothalamusThyrotropin-releasinghormone(TRH)DopamineGHRHSomatostatinCorticotropinreleasinghormone(CRH)OxytocinVasopressinThyroidGlandTriiodothyronine(T3)Thyroxine(T4)42GlandsandHormonesENDOCRINEGLANDHORMONESSECRETEDAdrenalGlands(cortexandmedulla)GlucocorticoidMineralocorticoidAndrogenAdrenalineNoradrenalineTestes(male)Androgen(testosterone)Ovaries(female)EstrogenProgesteronePancreasInsulinGlucagon43EndocrineTissuesHormonesarealsoproducedbyendocrinecellslocatedinorgansthathavenon-endocrinefuction.Werefertotheseasendocrinetissues.Theyincludethebrain,heart,kidneyandgastrointestinalTract.44EndocrineFeedbackForregulatethepituitarygland,asignalissentfromthehypothalamustothepituitaryglandintheformofa“releasinghormone,”whichstimulatesthepituitarytosecretea“stimulatinghormone”intothecirculation.Thestimulatinghormonethensignalsthetargetglandtosecreteitshormone.Whenthetargetedhormonewererisetomuch,overthenormalconcentrationatbloodstream,thehypothalamusandthepituitaryglandshutdownsecretionofthereleasinghormoneandthestimulatinghormone,sopossibletostopthetargethormones.Thissystemresultsinstablebloodconcentrationsofthehormones.45EndocrineFeedbackHypothalamussecretesTRH,whichcausesthepituitarytoreleaseTSH,whichcausesthethyroidglandtosecreteT4.Whenthebodyhasenoughthyroidhormoneintheblood,T4"feedsback"tothehypothalamusandpituitaryandcausesadecreaseinsecretionofTRHandTSH.46EndocrineGlandsPituitaryGlandPosteriorPituitaryAnteriorPituitaryThepituitaryglandisbeneaththehypothalamusandisnolargerthanapea.Itisoftenconsideredthemostimportantendocrinesystembecauseitproduceshormonesthatcontrolmanyfunctionsofotherendocrineglands.Whenthepituitaryglanddoesnotproduceoneormoreofitshormonesornotenoughofthem,itiscalledhypopituitarism.Thepituitaryglandisbeneaththehypothalamusandisnolargerthanapea.Itisoftenconsideredthemostimportantendocrinesystembecauseitproduceshormonesthatcontrolmanyfunctionsofotherendocrineglands.Whenthepituitaryglanddoesnotproduceoneormoreofitshormonesornotenoughofthem,itiscalledhypopituitarism.47EndocrineGlandsPituitaryGlandThehormonessecretedbytheposteriorpituitaryareactuallyproducedinthebrainandCarriedtothepituitaryglandthroughnerves.Theyarestoredinthepituitarygland.
Hormonesreleased:
Oxytocin
Vasopressin48EndocrineGlandsThyroidGlandThethyroidglandislocatedinthelowerfrontpartoftheneck.Itproducesthyroidhormonesthatregulatethebody'smetabolism.Italsoplaysaroleinbonegrowthanddevelopmentofthebrainandnervoussystem
inchildren.Thepituitaryglandcontrolsthereleaseofthyroidhormones.Thyroidhormonesalsohelpmaintainnormalbloodpressure,heartrate,digestion,muscletone,andreproductivefunctions.
49EndocrineGlandsParathyroidGlandFoursmallmassesofepithelialtissueareembeddedintheconnectivetissuecapsuleontheposteriorsurfaceofthethyroidglands.Parathyroidhormone(PTH)secretedbytheparathyroidglandsaffectscalciummetabolism.50EndocrineGlandsAdrenalGlandThetwoadrenalglandsarelocatedontopofeachkidney.Theadrenalglandsaremadeupoftwoparts.Theouterpartis
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