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ImmunoglobulinStructure-FunctionRelationship

免疫球蛋白的結(jié)構(gòu)與功能的關(guān)系SignallingantigenreceptorsonBcells-bifunctionalantigen-binding secretedmolecules(B細胞表面受體和分泌的抗體)Structuralconservationandinfinitevariability-domainstructure(結(jié)構(gòu)上不僅保守而且無限可變的).TheImmunoglobulinGeneSuperfamily(免疫球蛋白的超家族)Theimmunoglobulinfold(免疫球蛋白的折疊)Frameworkandcomplementaritydeterminingregions-hypervariable loops(框架結(jié)構(gòu)和可變區(qū))Modesofinteractionswithantigens(與抗原相互作用的模型)Effectormechanismsandisotype–roleoftheFc.(Fc區(qū)的作用)MultimericantibodiesandmultimerisationCharacteristicsandpropertiesofeachIgisotypeIgreceptorsandtheirfunctionsImmunoglobulinStructure-FunctionRelationshipCellsurfaceantigenreceptoronBcellsB細胞表面受體和分泌的抗體AllowsBcellstosensetheirantigenicenvironmentConnectsextracellularspacewithintracellularsignallingmachinerySecretedantibody(抗體) Neutralisation(中和作用) Arming/recruitingeffectorcells(激活或者誘導功能細胞) Complementfixation(幫助機體對抗原的清除)ImmunoglobulinStructure-FunctionRelationshipImmunoglobulinsareBifunctionalProteinsImmunoglobulinsmustinteractwithasmallnumberof specialisedmolecules-(免疫球蛋白必須與特殊分子相互作用) Fcreceptorsoncells(細胞表面的Fc受體) Complementproteins(輔助蛋白) Intracellularcellsignallingmolecules(細胞內(nèi)信號轉(zhuǎn)導分子)whilstsimultaneouslyrecognisinganinfinitearrayof antigenicdeterminants.(同時能夠識別無限抗原族)Structuralconservationandacapacityforinfinitevariabilityina singlemoleculeisprovidedbyaDOMAINstructure.(結(jié)構(gòu)上不僅保守而且無限可變的-抗體結(jié)構(gòu)域)Igdomainsarederivedfromasingleancestralgenethathas duplicated,diversifiedandbeenmodifiedtoendowan assortmentoffunctionalqualitiesonacommonbasicstructure(Ig結(jié)構(gòu)域源于一個原始基因,復制,多元化,修飾等)Igdomainsarenotrestrictedtoimmunoglobulins(Ig結(jié)構(gòu)域不僅僅局限于免疫球蛋白).ThemoststrikingcharacteristicoftheIgdomainisadisulphide bond-linkedstructureof110aminoacidslong(Ig結(jié)構(gòu)域最明顯的特點是其雙硫鍵,連接了110個氨基酸).ImmunoglobulindomainsThegenesencodingIgdomainsarenotrestrictedtoIggenes.Althoughfirstdiscoveredinimmunoglobulins,theyarefoundinasuperfamilyofrelatedgenes,particularlythoseencodingproteinscrucialtocell-cellinteractionsandmolecularrecognitionsystems.IgSFmoleculesarefoundinmostcelltypesandarepresentacrosstaxonomicboundariesIggenesuperfamily-IgSFAntibodiesareProteinsthatRecognizeSpecificAntigens

抗體能夠特異性的識別抗原Epitopes(抗原決定簇):AntigenRegionsthatInteractwithAntibodiesConsequencesofAntibodyBinding

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