Sutezolid-PNU-100480-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESutezolidCat.No.:HY-10392CASNo.:168828-58-8Synonyms:PNU-100480;U-100480;PF-02341272分?式:C??H??FN?O?S分?量:353.41作?靶點(diǎn):Bacterial;Antibiotic作?通路:Anti-infection儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(141.48mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.8296mL14.1479mL28.2957mL5mM0.5659mL2.8296mL5.6591mL10mM0.2830mL1.4148mL2.8296mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%saline1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(7.07mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.5mg/mL(7.07mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(7.07mM);ClearsolutionBIOLOGICALACTIVITY?物活性Sutezolid(PNU-100480)?種具有?服活性惡唑烷酮抗劑，通過抑制細(xì)蛋?質(zhì)合成發(fā)揮作?。Sutezolid具有較強(qiáng)的抗分枝桿活性，?于耐藥結(jié)核病的研究。IC50&TargetOxazolidinone體外研究Sutezolid(PNU-100480)exhibitsexcellentinvitroactivityagainstmultipleclinicalisolatesofMycobacteriumaviumcomplex(MIC’s=0.5-4μg/mL)[1].體內(nèi)研究Sutezolid(PNU-100480)isathiomorpholinylanalogoflinezolidwithsuperiorefficacyagainstM.tuberculosisinthehollow-fiber,mouse,andwhole-bloodmodels[3].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?AntimicrobAgentsChemother.2021Jan25;AAC.01445-20.?DisModelMech.2021Oct13;dmm.049145.?JPharmBiomedAnal.2019May30;169:196-207.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].BarbachynMR,etal.Identificationofanoveloxazolidinone(U-100480)withpotentantimycobacterialactivity.JMedChem.1996;39(3):680-685.[2].NicoleSalazar-Austin,etal.Sutezolid.InKucerstheUseofAntibiotics:AClinicalReviewofAntibacterial,Antifungal,Antiparasitic,andAntiviralDrugs,SeventhEdition(pp.2559-2563).CRCPress.[3].ZhuT,etal.Populationpharmacokinetic/pharmacodynamicanalysisofthebactericidalactivitiesofsutezolid(PNU-100480)anditsmajormetaboliteagainstintracellularMycobacteriumtuberculosisinexvivowhole-bloodculturesofpatientswithpulmonarytuberculosis.AntimicrobAgentsChemother.2014;58(6):3306-3311.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications