R-BAY-85-8501-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(R)-BAY-85-8501Cat.No.:HY-19908BCASNo.:2446175-39-7分?式:C??H??F?N?O?S分?量:474.46作?靶點(diǎn):Others作?通路:Others儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(210.77mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.1077mL10.5383mL21.0766mL5mM0.4215mL2.1077mL4.2153mL10mM0.2108mL1.0538mL2.1077mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(5.27mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.27mM);ClearsolutionBIOLOGICALACTIVITY?物活性(R)-BAY-85-8501BAY-85-8501活性較低的對(duì)映體。BAY-85-8501?類(lèi)中性脂酶(HNE)的?個(gè)有效的、選擇性抑制劑，其IC50值為65pM。戶(hù)使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?ChineseAcademyofSciences.2019Aug.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].VonNussbaumF,etal.FreezingtheBioactiveConformationtoBoostPotency:TheIdentificationofBAY85-8501,aSelectiveandPotentInhibitorofHumanNeutrophilElastaseforPulmonaryDiseases.ChemMedChem.2015Jul;10(7):1163-73.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589559