β-Amyrone-β-Amyron-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEβ-AmyroneCat.No.:HY-N2925CASNo.:638-97-1Synonyms:β-Amyron分?式:C??H??O分?量:424.7作?靶點(diǎn):Fungal;COX;PPAR作?通路:Anti-infection;Immunology/Inflammation;CellCycle/DNADamage儲(chǔ)存?式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)BIOLOGICALACTIVITY?物活性β-Amyrone(β-Amyron)?種三萜類(lèi)化合物，通過(guò)抑制COX-2的表達(dá)?發(fā)揮抗炎活性。β-Amyrone具有抗真活性，及針對(duì)Chikungunya病毒的抗病毒活性。β-Amyrone還可抑制α-葡萄糖苷酶(α-glucosidase)和?酰膽堿酯酶(AChE)的活性。β-Amyrone可?于炎癥，感染，肥胖等疾病的研究。IC50&TargetCOX-2體外研究β-Amyrone(1.25-10μg/mL,24h)inhibitsonNO?productioninLPS-stimulatedJ774cells,withanIC50valueof4.61μg/mL,andhasnoobviouseffectoncellviability[1].β-Amyrone(10μg/mL,24h)inhibitsIL-6,IL-10levels,andCOX-2expressioninLPS-stimulatedJ774cells[1].β-Amyrone(0-235μM,7days)hasantiviralactivityinVerocellsagainstChikungunyavirus(CHIKV),withEC50valueof86uM[2].β-Amyroneinhibitsα-glucosidase,acetylcholinesterase(AChE)andfungalactivitywithIC50valuesof25μM,23μMand8μg/mL,respectively[4].WesternBlotAnalysis[1]CellLine:LPS(1μg/mL)-stimulatedJ774cellsConcentration:2.5,5,10μg/mL1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIncubationTime:24hResult:InhibitedCOX-2expressioninaconcentration-dependentmanner(approximately90%reductionat5or10μg/mL).體內(nèi)研究β-Amyrone(localadministrationonear,0.1-0.6mg/kg,asingledose)inhibitsearedemaformationinphenol-inducededemamice[1].AnimalModel:Earphenol-inducededemainBalbCmice[1]Dosage:0.1,0.3,0.6mg/kg,asingledoseAdministration:Localadministration(20?Lsolution)onearResult:Inhibitedearedemaformationinadose-relatedmanner(47%inhibitionatthedoseof0.6mg/kg).REFERENCES[1].PatríciaDOdeAlmeida,etal.Anti-InflammatoryActivityofTriterpenesIsolatedfromProtiumpaniculatumOil-Resins.EvidBasedComplementAlternatMed.2015;2015:293768.[2].MélanieBourjot,etal.ChemicalconstituentsofAnacolosapervilleanaandtheirantiviralactivities.Fitoterapia.2012Sep;83(6):1076-80.[3].Ki-KwangOh,etal.ElucidatingDrug-LikeCompoundsandPotentialMechanismsofCornSilk(StigmaMaydis)againstObesity:ANetworkPharmacologyStudy.CurrIssuesMolBiol.2021Nov6;43(3):1906-1936.[4].AtaA,etal.ChemicalconstituentsofDrypetesgossweileriandtheirenzymeinhibitoryandanti-fungalactivities.PhytochemistryLetters,2011,4(1):34-37.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.F