PROTAC-CBP-P300-Degrader-1-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEPROTACCBP/P300Degrader-1Cat.No.:HY-138536CASNo.:2484739-48-0分?式:C??H??F?N??O?分?量:893.98作?靶點(diǎn):PROTACs;EpigeneticReaderDomain作?通路:PROTAC;Epigenetics儲存?式:-20°C,sealedstorage,awayfrommoistureandlight*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoistureandlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:173.33mg/mL(193.89mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM1.1186mL5.5930mL11.1859mL5mM0.2237mL1.1186mL2.2372mL10mM0.1119mL0.5593mL1.1186mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoistureandlight)。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲備液可以根據(jù)儲存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:6.5mg/mL(7.27mM);Suspendedsolution;Needultrasonic1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性PROTACCBP/P300Degrader-1?種有效的PROTACCBP/P300降解劑。PROTACCBP/P300Degrader-1有效抑制多個(gè)癌細(xì)胞系的細(xì)胞活?。IC50&TargetCereblon體外研究PROTACCBP/P300Degrader-1showsLNCaPprostatecancercellviabilityinhibition(IC50=0.4nM).PROTACCBP/P300Degrader-1(10nM)inducesdegradationofP300(≥80%)[1].PROTACCBP/P300Degrader-1potentlyinhibitedcellviabilityofmultiplecancelcelllines(IC50srangingfrom0.1-141.4nMforHEL,NOMO-1,MOLM-13,HL-60,MEG-01,MM.IS,MM.1R,NCL-H929,RPM-8226,AMO-1,WSU-DLCL2,Karpas-422,Pfeiffer,SU-DHL-1,LNCapcloneFGC,VCap;22RV1,NCI-H520,NCI-H703,LK-2,MCE-7,andSK-BR-3cells)[1].REFERENCES[1].JingLiu,etal.Cyclic-ampresponseelementbindingprotein(cbp)and/oradenovirale1abindingproteinof300kda(p300)degradationcompoundsandmethodsofuse.WO2020173440A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: