Mecillinam-Amdinocillin-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?Agonists?ScreeningLibrarieswww.MedChemEMecillinamCat.No.:HY-A0269CASNo.:32887-01-7Synonyms:Amdinocillin;FL1060分?式:C??H??N?O?S分?量:325.43作?靶點(diǎn):Bacterial作?通路:Anti-infection儲(chǔ)存?式:4°C,protectfromlight,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:250mg/mL(768.21mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.0729mL15.3643mL30.7286mL5mM0.6146mL3.0729mL6.1457mL10mM0.3073mL1.5364mL3.0729mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存?式和期限。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案，配制前請(qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分?指該溶劑在您配制終溶液中的體積占?)：1.請(qǐng)依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥6.25mg/mL(19.21mM);Clearsolution2.請(qǐng)依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥6.25mg/mL(19.21mM);Clearsolution3.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥6.25mg/mL(19.21mM);Clearsolution1/2MasterofSmallMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Mecillinam(Amdinocillin)?種β內(nèi)酰胺類(lèi)抗?素，具有?譜的抗?蘭?性的活性。體內(nèi)研究Mecillinam(Amdinocillin,400mgperkg)iseffectiveforthetreatmentofcatheterassociatedinfectionsathighdosages(400mgperkgofbodyweight/d)[1].AnimalModel:Mecillinam(Amdinocillin,400mgperkg)iseffectiveforthetreatmentofcatheterassociatedinfectionsathighdosages(400mgperkgofbodyweight/d)[1].Dosage:50,100,200,and400mgperkg.Administration:Intravenouslyeachdayinfourdivideddosesovera72-hperiod.Result:Highdoseof400mg/kgexhibitedsignificantactivity.REFERENCES[1].MEOlson,etal.AmdinocillinTreatmentofCatheter-AssociatedBacteriuriainRabbits.JInfectDis.1989Jun;159(6):1065-72.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te