Antitrypanosomal-agent-1-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAntitrypanosomal agent 1Cat. No.: HY-W052512CAS No.: 75144-12-6分式: CHClNO分量: 282.59作靶點(diǎn): Parasite作通路: Anti-infection儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 25 mg/mL (88.47 mM; Need u

2、ltrasonic)H2O : 10 mg/mL (35.39 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.5387 mL 17.6935 mL 35.3870 mL5 mM 0.7077 mL 3.5387 mL 7.0774 mL10 mM 0.3539 mL 1.7693 mL 3.5387 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) 請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢?qǐng)先配制澄的儲(chǔ)備液，再依次添加助溶劑(為保證實(shí)

3、驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；以下溶劑前的百分指該溶劑在您配制終溶液中的體積占)：1. 請(qǐng)依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (8.85 mM); Clear solution2. 請(qǐng)依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (8.85 mM); Clear solution1/2 Master of Small Molecules

4、 您邊的抑制劑師www.MedChemEBIOLOGICAL ACTIVITY物活性 Antitrypanosomal agent 1種有效的，選擇性錐硫磷還原酶 (trypanothione reductase) 抑制劑，IC50為 3.3 M。Antitrypanosomal agent 1 抑制胱肽還原酶 (glutathione reductase)，IC50 為 64.8 M；抑制布錐，EC50 為 1 M。Antitrypanosomal agent 1 具有抗錐活性。IC50 & Target IC50: 3.3 M (trypanothione reductase) and 6

5、4.8 M (glutathione reductase) 1EC50: 1 M (T. brucei) 1體外研究 Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20 1.REFERENCES1. Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomalactivity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;