網(wǎng)絡(luò)藥理學(xué) - 副本課件

1、 Network pharmacology for FangJiomics approach Network pharmacologyA new perspective to understand principle of drug combination inTraditional Chinese Medicine ?君 - King臣 - Minister佐 - Assistant使 - AmbassadorDifferent Roles of the Gene Modules& their cooperation effectsThe information to deliverNetw

2、ork could be drug targetNetwork pharmacology belongs to a division of systems biology and provides a synergistic strategies and comprehensive approaches to reveal the inner network relationships between modern drugs and human body function. Notably, it is very helpful for screening active components

3、, exploring potential targets and clarifying complex mechanisms in TCM via highthroughput technologies of network pharmacologyGene Module DatabaseProteinNetworkPathwayGene OntologymiRNA Target GeneGene ModuleDatabase Table1.The top 10 compounds with the most targetsFigure4A.The top compound-target p

4、athway networks of XKA in the treatment of T2D. (A).The compound-target pathway networks with compounds identified by LC-MS analysis (NCA)Figure4B.(B)The top compound-target pathway network with compounds collected from databases(NCD)Green diamond nodes represent compoundsThe node size is proportional to the degree of the Green.Pink circle nodes represent target genesPurple rounded square nodes represent T2D-associated pathwaysGreen edges link compounds to target genes and blu edges link target genes to T2D-associated pathways展望通過生物學(xué)網(wǎng)絡(luò)中節(jié)點(diǎn)的連接和關(guān)系來分析網(wǎng)絡(luò)特性，進(jìn)一步闡明藥物作用機(jī)制通過網(wǎng)絡(luò)藥理學(xué)的研