MS31-trihydrochloride-DataSheet-生命科學(xué)試劑-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEMS31 trihydrochlorideCat. No.: HY-125837A分式: CHClNO分量: 450.83作靶點(diǎn): Epigenetic Reader Domain作通路: Epigenetics儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 62.5 mg/mL (138.63 mM; Need ultraso

2、nic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 2.2181 mL 11.0907 mL 22.1813 mL5 mM 0.4436 mL 2.2181 mL 4.4363 mL10 mM 0.2218 mL 1.1091 mL 2.2181 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 MS31 trihydrochloride種親和性和選擇性的，段樣的甲賴氨酸讀寫蛋 spindlin 1 (SPIN1) 抑制劑，有效破壞 SPIN1 與

3、H3K4me3 蛋互相作 (IC50=77 nM，AlphaLISA；243 nM，F(xiàn)P). MS31trihydrochloride 選擇性結(jié)合 SPIN1 的 Tudor 結(jié)構(gòu)域 II (Kd=91 nM)。MS31 trihydrochloride 能有效抑制含三甲賴氨酸肽與 SPIN1 的結(jié)合，對(duì)腫瘤性細(xì)胞毒 1。IC50 & Target IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP) 1Kd: 91 nM (SPIN1) 11/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE

4、體外研究 MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays highbinding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engagesSPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 trihydrochlorid

5、e selectively binds tudor domainII of SPIN1 1.REFERENCES1. Xiong Y, et al. Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1(SPIN1). J MedChem. 2019 Jul 24.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-589