磷酸化活化轉(zhuǎn)錄因子1抗體供應(yīng)

1、磷酸化活化轉(zhuǎn)錄因子1抗體供應(yīng)別名ATF1(phosphoS63);p-ATF1(phosphoS63);ActivatingTranscriptionFactor1;TREB36protein;ATF1;ATF1EWSfusiongeneATF1FUSfusiongene;cAMPdependenttranscriptionfactor1;CyclicAMPdependenttranscriptionfactorATF1;CyclicAMPdependenttranscriptionfactorATF1;EWSAFT1;FUSATF1;RNAbindingproteinactivatingtr

2、anscriptionfactor1fusionprotein;TREB36;TREB36.濃度1mg/1ml規(guī)格0.1ml/100g抗體來源Rabbit克隆類型polyclonal交叉反應(yīng)Human,Mouse產(chǎn)品類型一抗磷酸化抗體研究領(lǐng)域轉(zhuǎn)錄調(diào)節(jié)因子表觀遺傳學(xué)蛋白分子量predictedmolecularweight:29kDa性狀LyophilizedorLiquid免疫原KLHconjugatedsynthesisedphosphopeptidederivedfromhumanATF1aroundthephosphorylationsiteofSer63亞型IgG純化方法affinit

3、ypurifiedbyProteinA儲存液Preservative:15mMSodiumAzide,Constituents:1%BSA,0.01MPBS,pH7.4產(chǎn)品應(yīng)用WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蠟切片需做抗原修復(fù)）notyettestedinotherapplications.optimaldilutions/concentrationsshouldbedeterminedbytheenduser.保存條件Storeat-20Cforoneye

4、ar.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20C.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4C.ImportantNoteThisproductassuppliedisintendedforresearchuseonly

5、,notforuseinhuman,therapeuticordiagnosticapplications.產(chǎn)品介紹ATF1(ActivatingTranscriptionFactor1,TREB-36)isamemberoftheATF/CREBfamilyofbasicregionleucine-zipper(bZip)DNA-bindingproteinsthatregulatestranscriptionbybindingtoaconsensuscAMPresponseelement(CRE)inthepromoter磷酸化活化轉(zhuǎn)錄因子1抗體供應(yīng)ofvariousviralandcel

6、lulargenes.Manyofthesegenesareimportantincellgrowthanddifferentiation,andinstressandimmuneresponses.TheactivationfunctionofCRE-bindingproteinsmaybemodulatedbyphosphorylationofseveralkinasesandismediatedbycoactivatorssuchasCREB-bindingprotein(CBP)andp300.ATF1isanuclearproteinthatbindsDNAasahomodimero

7、rasheterodimerswiththeinducibletranscriptionfactorsCREB1orCREM.Heterodimersappeartobestrongertranscriptionalactivatorsthanthehomodimers.TissueexpressionofATF1mRNAiswidespread.SeveralisoformsofATF1arisebydifferentialsplicing.ATF1mediatesbothCa2+andcAMPresponsesatseverallevels.ItbindstotheTax-responsi

8、veelement(TRE1)ofthehumanT-celllymphotropicvirustype-I(HTLV1).ATF1isdetectableinmetastaticmelanomacellsandseemstocontributetotheirsurvival.AchimericproteincomposedoftheN-terminaldomainofEWS(Ewingsarcomaoncogene)linkedtothebZipdomainofATF1isimplicatedintheraremalignantclearcellsarcomaoftendonsheathan

9、daponeuroses(malignantmelanomaofsoftparts).Function:ThisproteinbindsthecAMPresponseelement(CRE)(consensus:5-GTGACGTACAG-3),asequencepresentinmanyviralandcellularpromoters.BindstotheTax-responsiveelement(TRE)ofHTLV-I.MediatesPKA-inducedstimulationofCRE-reportergenes.SubcellularLocation:Nucleus.DISEAS

10、E:DefectsinATF1maybeacauseofangiomatoidfibroushistiocytoma(AFH)MIM:612160.Adistinctvariantofmalignantfibroushistiocytomathattypicallyoccursinchildrenandadolescentsandismanifestbynodularsubcutaneousgrowth.Characteristicmicroscopicfeaturesincludelobulatedsheetsofhistiocyte-likecellsintimatelyassociate

11、dwithareasofhemorrhageandcysticpseudovascularspaces,aswellasastrikingcuffingofinflammatorycells,mimickingalymphnodemetastasis.Note=ChromosomalaberrationsinvolvingATF1arefoundinpatientswithangiomatoidfibroushistiocytoma.Translocationt(12;16)(q13;p11.2)withFUSgeneratesachimericATF1/FUSprotein.Transloc

12、ationt(12;22)(q13;q12)withEWSR1generatesachimericATF1/EWSR1protein.Similarity:BelongstothebZIPfamily.ATFsubfamily.Contains1bZIPdomain.Contains1KID(kinase-inducible)domain.E-(Hu)（03）-01041 人周期素依賴性激酶1(CDK-1)elisa試劑盒 ，英文名： Cyclin-dependentkinase1,CDK-1ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01042 人磷酸化腺苷酸活化蛋白激酶

13、(AMPK)elisa試劑盒 ，英文名： Phosphorylatedadenosinemonophosphateactivatedproteinkinase,AMPKELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01043 人解整合素樣金屬蛋白酶9(ADAM9)elisa試劑盒 ，英文名： ADisintegrinAndMetalloprotease9,ADAM9ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01044 人位淀粉樣前體蛋白裂解酶2(BACE2)elisa試劑盒 ，英文名： beta-siteAPP-cleavingenzyme2,BACE2

14、ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01045 人尿嘧啶核苷磷酸化酶1(UPP1)elisa試劑盒 ，英文名： uridinephosphorylase1,UPP1ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01046 人乙醇脫氫酶(ADH)elisa試劑盒 ，英文名： alcoholdehydrogenase,ADHELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01047 人乙醛脫氫酶(ALDH)elisa試劑盒 ，英文名： aldehydedehydrogenase,ALDHELISAKit ，規(guī)格： 96T/48TE-(H

15、u)（03）-01048 人Rho家族GTP酶1(RND1)elisa試劑盒 ，英文名： RhofamilyGTPase1,RND1ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01049 人受體TNFRSF結(jié)合絲氨酸蘇氨酸激酶2(RIPK2)elisa試劑盒 ，英文名： receptorTNFRSF-interactingserine-threoninekinase2,RIPK2ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01050 人磷脂爬行酶1(PLSCR1)elisa試劑盒 ，英文名： phospholipidscramblase1,PLSCR1E

16、LISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01051 人3-羥基-3-甲基戊二酰輔酶A合酶1(HMGCS1)elisa試劑盒 ，英文名： 3-hydroxy-3-methylglutaryl-CoenzymeAsynthase1,HMGCS1ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01052 人嗜酸性白血球相關(guān)之RNA水解酵素家族成員12(EAR12)elisa試劑盒 ，英文名： eosinophil-associatedribonucleaseAfamilymember12,EAR12ELISAKit ，規(guī)格： 96T/48TE-(Hu)（03）-01053 人嗜酸性白血球相關(guān)之RNA水解酵素家族成員3(EAR3)elisa試劑盒 ，英文名： eosinophil-associatedribonucleaseAfamilymember3,EAR3ELISAK